Palladium-catalyzed synthesis of 3-alkoxysubstituted indoles
摘要:
Indoles having an electron-donating alkoxy-group in the 3-position were prepared from 1-(2-nitrophenyl)-l-alkoxyalkene derivatives via a palladium-catalyzed reductive N-heteroarmulation using carbon monoxide as the ultimate reducing agent. The required starting materials were prepared by a Stille coupling of 2-balonitroarenes with tributyl(1-ethoxyethenyl)stannane or tributyl(3,4-dihydro-2H-pyran-6-yl)stannane. (c) 2006 Elsevier Ltd. All rights reserved.
Mild and General Cross-Coupling of (α-Alkoxyvinyl)silanols and -silyl Hydrides
摘要:
[GRAPHICS](alpha-Alkoxyvinyl)silanols and (alpha-alkoxyvinyl)silyl hydrides are efficiently converted to aryl vinyl ethers by a palladium(0)-catalyzed cross-coupling reaction with aryl halides in the presence of tetrabutylammonium fluoride or hydroxide. Yields are generally high, and the reaction is compatible with a wide range of functional groups.
Palladium-Catalyzed Cross-Coupling Reactions between Dihydropyranylindium Reagents and Aryl Halides. Synthesis of <i>C</i>-Aryl Glycals
作者:Ute Lehmann、Smita Awasthi、Thomas Minehan
DOI:10.1021/ol0345428
日期:2003.7.1
[reaction: see text] Palladium(0)-catalyzed cross-coupling reactions between tris(dihydropyranyl)indium 1 and aryl halides 2 have been investigated. Aryl iodides and electron-deficient aryl bromides couple efficiently with the in situ-generated indium reagents in the presence of 1-5 mol % Cl(2)Pd(PPh(3))(2) to produce substituted dihydropyrans 3 with minimal (<10%) dimer (4) formation. Organoindium
Mild and General Cross-Coupling of (α-Alkoxyvinyl)silanols and -silyl Hydrides
作者:Scott E. Denmark、Luc Neuville
DOI:10.1021/ol0064112
日期:2000.10.1
[GRAPHICS](alpha-Alkoxyvinyl)silanols and (alpha-alkoxyvinyl)silyl hydrides are efficiently converted to aryl vinyl ethers by a palladium(0)-catalyzed cross-coupling reaction with aryl halides in the presence of tetrabutylammonium fluoride or hydroxide. Yields are generally high, and the reaction is compatible with a wide range of functional groups.
Palladium-catalyzed synthesis of 3-alkoxysubstituted indoles
作者:Ronald W. Clawson、Robert E. Deavers、Novruz G. Akhmedov、Björn C.G. Söderberg
DOI:10.1016/j.tet.2006.08.101
日期:2006.11
Indoles having an electron-donating alkoxy-group in the 3-position were prepared from 1-(2-nitrophenyl)-l-alkoxyalkene derivatives via a palladium-catalyzed reductive N-heteroarmulation using carbon monoxide as the ultimate reducing agent. The required starting materials were prepared by a Stille coupling of 2-balonitroarenes with tributyl(1-ethoxyethenyl)stannane or tributyl(3,4-dihydro-2H-pyran-6-yl)stannane. (c) 2006 Elsevier Ltd. All rights reserved.