bis(2-oxo-3(1H)-pyridyl) disulfide | 173278-50-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: bis(2-oxo-3(1H)-pyridyl) disulfide
• 英文别名: 3-[(2-oxo-1H-pyridin-3-yl)disulfanyl]-1H-pyridin-2-one
• CAS: 173278-50-7
• 化学式: C₁₀H₈N₂O₂S₂
• 分子量: 252.318
• InChiKey: YUNLBOUWOMSCHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  bis(2-oxo-3(1H)-pyridyl) disulfide 在 sodium methylate 、 肼 作用下， 以 乙醇 为溶剂， 反应 55.0h， 生成 1,6-diazaphenoxanthiine
  参考文献：
  名称：

  First Synthesis of 3-Mercapto-2(1H)-pyridinone, a Simple Disubstituted Pyridine Useful for Synthesis of the 4-Azaphenoxathiine Ring System and Its Novel Diazaphenoxathiine Analogs:  1,6-Diazaphenoxathiine and 2,6-Diazaphenoxathiine¹

  摘要：

  3-Mercapto-2(1H)-pyridinone (1) can be synthesized in three simple high-yielding steps from readily available 2-tert-butylthiazolo[4,5-b]pyridine (2). Its disodium salt condenses with o-chloronitrobenzene, 2-chloro-3-nitropyridine, and 3-chloro-4-nitropyridine 1-oxide to give respectively 4-azaphenoxathiine (10), 1,6-diazaphenoxathiine (12), and 2,6-diazaphenoxathiine 2-oxide (14) which reduces to 2,6-diazaphenoxathiine (15). The structures of these previously unreported azaphenoxathiine systems were confirmed by assignment of their respective C-13 NMR spectra.

  DOI：

  10.1021/jo951254j
• 作为产物：
  描述：

  3-[(2-氨基吡啶-3-基)二硫烷基]吡啶-2-胺 在 硫酸 、 sodium nitrite 作用下， 以 水 为溶剂， 以71%的产率得到bis(2-oxo-3(1H)-pyridyl) disulfide
  参考文献：
  名称：

  First Synthesis of 3-Mercapto-2(1H)-pyridinone, a Simple Disubstituted Pyridine Useful for Synthesis of the 4-Azaphenoxathiine Ring System and Its Novel Diazaphenoxathiine Analogs:  1,6-Diazaphenoxathiine and 2,6-Diazaphenoxathiine¹

  摘要：

  3-Mercapto-2(1H)-pyridinone (1) can be synthesized in three simple high-yielding steps from readily available 2-tert-butylthiazolo[4,5-b]pyridine (2). Its disodium salt condenses with o-chloronitrobenzene, 2-chloro-3-nitropyridine, and 3-chloro-4-nitropyridine 1-oxide to give respectively 4-azaphenoxathiine (10), 1,6-diazaphenoxathiine (12), and 2,6-diazaphenoxathiine 2-oxide (14) which reduces to 2,6-diazaphenoxathiine (15). The structures of these previously unreported azaphenoxathiine systems were confirmed by assignment of their respective C-13 NMR spectra.

  DOI：

  10.1021/jo951254j

文献信息

• [EN] GAMMA SECRETASE INHIBITORS<br/>[FR] INHIBITEURS DE GAMMA SÉCRÉTASE
  申请人：MERCK SHARP & DOHME

  公开号：WO2013036464A1

  公开（公告）日：2013-03-14

  Disclosed herein are compounds of Formula (I) (I) and pharmaceutically acceptable salts thereof, wherein each of the substituents is given the definition as set forth in the specification and claims. Also disclosed are pharmaceutical compositions containing the compound of Formula (I) and use of the compound in the treatment of neurodegenerative diseases or conditions such as Alzheimer's disease.

  本文披露了公式(I) (I)的化合物及其药学上可接受的盐，其中每个取代基的定义如规范和权利要求所述。还披露了含有公式(I)化合物的药物组合物以及使用该化合物治疗神经退行性疾病或病症，如阿尔茨海默病。
• GAMMA SECRETASE INHIBITORS
  申请人：Wu Wen-Lian

  公开号：US20140227302A1

  公开（公告）日：2014-08-14

  Disclosed herein are compounds of Formula (I) (I) and pharmaceutically acceptable salts thereof, wherein each of the substituents is given the definition as set forth in the specification and claims. Also disclosed are pharmaceutical compositions containing the compound of Formula (I) and use of the compound in the treatment of neurodegenerative diseases or conditions such as Alzheimer's disease.
• US9226927B2
  申请人：——

  公开号：US9226927B2

  公开（公告）日：2016-01-05
• First Synthesis of 3-Mercapto-2(1<i>H</i>)-pyridinone, a Simple Disubstituted Pyridine Useful for Synthesis of the 4-Azaphenoxathiine Ring System and Its Novel Diazaphenoxathiine Analogs:  1,6-Diazaphenoxathiine and 2,6-Diazaphenoxathiine¹
  作者：Keith Smith、Dorian Anderson、Ian Matthews

  DOI：10.1021/jo951254j

  日期：1996.1.1

  3-Mercapto-2(1H)-pyridinone (1) can be synthesized in three simple high-yielding steps from readily available 2-tert-butylthiazolo[4,5-b]pyridine (2). Its disodium salt condenses with o-chloronitrobenzene, 2-chloro-3-nitropyridine, and 3-chloro-4-nitropyridine 1-oxide to give respectively 4-azaphenoxathiine (10), 1,6-diazaphenoxathiine (12), and 2,6-diazaphenoxathiine 2-oxide (14) which reduces to 2,6-diazaphenoxathiine (15). The structures of these previously unreported azaphenoxathiine systems were confirmed by assignment of their respective C-13 NMR spectra.