N-acetyl-γ-methyl-d,l-leucine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-acetyl-γ-methyl-d,l-leucine
• 英文别名: N-acetyl-α-neopentylglycine；2-Acetamido-4,4-dimethylpentanoic acid
• 化学式: C₉H₁₇NO₃
• 分子量: 187.239
• InChiKey: DGGQDBMYIWFFHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-acetyl-γ-methyl-d,l-leucine 在 N,N'-二环己基碳二亚胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成 N-acetyl-L-neopentylglycine methyl amide
  参考文献：
  名称：

  Pospisek, Jan; Blaha, Karel, Collection of Czechoslovak Chemical Communications, 1987, vol. 52, # 2, p. 514 - 521

  摘要：

  DOI：
• 作为产物：
  描述：

  2-amino-4,4-dimethyl-pentanenitrile 在 盐酸 、 sodium hydroxide 、 氢溴酸 、 乙酸酐 作用下， 反应 8.0h， 生成 N-acetyl-γ-methyl-d,l-leucine
  参考文献：
  名称：

  Pospisek, Jan; Blaha, Karel, Collection of Czechoslovak Chemical Communications, 1987, vol. 52, # 2, p. 514 - 521

  摘要：

  DOI：

文献信息

• ALKYLAMINE-SUBSTITUTED PERTHIOCARBAMATES AS DUAL PRECURSORS TO HYDROPERSULFIDE AND CARBONYL SULFIDE
  申请人：The Johns Hopkins University

  公开号：US20210238134A1

  公开（公告）日：2021-08-05

  Alkylamine-substituted perthiocarbamates capable of controllable release of hydropersulfides (RSSH) and carbonyl sulfide (COS) and their use in treating or preventing ischemia-reperfusion injury are described.

  描述了能够控制释放过硫酸氢（RSSH）和羰基硫化物（COS）的烷基胺取代过硫氨酸盐，以及它们在治疗或预防缺血再灌注损伤中的应用。
• COMPOSITION FOR IMPROVING OIL RECOVERY INCLUDING N-LAUROYL AMINO ACID-BASED COMPOUNDS AND MICROBES
  申请人：Choban Eric R.

  公开号：US20120292022A1

  公开（公告）日：2012-11-22

  Chemical compounds that are N-lauroyl amino acids or derivatives thereof were found to have oil-releasing activity. Solutions containing these compounds and microorganisms having oil release and/or plugging biofilm formation properties may be introduced into oil reservoirs to improve oil recovery.
• OIL RELEASE WITH N-LAUROYL AMINO ACID-BASED COMPOUNDS
  申请人：Choban Eric R.

  公开号：US20120295823A1

  公开（公告）日：2012-11-22

  Chemical compounds that are N-lauroyl amino acids or derivatives thereof were found to have oil-releasing activity. Solutions containing these compounds may be introduced into oil reservoirs or onto oil-contaminated surface sites to release oil from oil-coated surfaces. The released oil may be recovered for further processing or waste disposal.
• HETEROARYL COMPOUNDS AND USES THEREOF
  申请人：Celgene Avilomics Research, Inc.

  公开号：US20170095475A1

  公开（公告）日：2017-04-06

  The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.