1-[(E)-4,4-dimethylpent-1-enyl]-2-methoxybenzene | 1422381-73-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-[(E)-4,4-dimethylpent-1-enyl]-2-methoxybenzene
• CAS: 1422381-73-4
• 化学式: C₁₄H₂₀O
• 分子量: 204.312
• InChiKey: RXALKUFYDNDFDU-VQHVLOKHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4,4-二甲基-1-戊烯 、 2-溴苯甲醚 在 二(三叔丁基膦)钯 、 N-甲基二环己基胺 、 4,4'-二叔丁基苯并 、 四丁基氯化铵 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 反应 24.0h， 生成 1-[(E)-4,4-dimethylpent-1-enyl]-2-methoxybenzene 、 (E)-1-(4,4-dimethylpent-2-en-1-yl)-2-methoxybenzene 、 1-(4,4-dimethylpent-1-en-2-yl)-2-methoxybenzene
  参考文献：
  名称：

  A Robust First-Pass Protocol for the Heck–Mizoroki Reaction

  摘要：

  The Heck-Mizoroki (HM) reaction is one of the most widely used C-C bond-forming methods of contemporary synthesis. Notwithstanding this, these reactions frequently require significant optimization before efficient transformations can be obtained. We describe here the results of a study that aimed to establish a generic experimental protocol for HM reactions which enables acceptable yields from first-pass experiments. The methodology utilizes readily available stable catalysts and can be applied to a broad range of coupling partners.

  DOI：

  10.1021/op300364p

文献信息

• A Robust First-Pass Protocol for the Heck–Mizoroki Reaction
  作者：Paul M. Murray、John F. Bower、David K. Cox、Ewan K. Galbraith、Jeremy S. Parker、Joseph B. Sweeney

  DOI：10.1021/op300364p

  日期：2013.3.15

  The Heck-Mizoroki (HM) reaction is one of the most widely used C-C bond-forming methods of contemporary synthesis. Notwithstanding this, these reactions frequently require significant optimization before efficient transformations can be obtained. We describe here the results of a study that aimed to establish a generic experimental protocol for HM reactions which enables acceptable yields from first-pass experiments. The methodology utilizes readily available stable catalysts and can be applied to a broad range of coupling partners.