N,N'-(decane-1,10-diyl)diacrylamide | 10405-47-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N'-(decane-1,10-diyl)diacrylamide
• 英文别名: N,N'-decamethylenebis(acrylamide)；1,10-decylenediacrylamide；1,10-diaminodecane diacrylate；DDA；1,10-Decylene diacrylamide；N-[10-(prop-2-enoylamino)decyl]prop-2-enamide
• CAS: 10405-47-7
• 化学式: C₁₆H₂₈N₂O₂
• 分子量: 280.411
• InChiKey: OXZMJPQKHGOTGJ-UHFFFAOYSA-N

物化性质

• 沸点：
  501.8±36.0 °C(Predicted)
• 密度：
  0.951±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  20
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N'-(decane-1,10-diyl)diacrylamide 、 1,3-二(4-哌啶基)丙烷 以 甲醇 为溶剂， 反应 24.0h， 以1.7 g的产率得到N,N'-(decane-1,10-diyl)bis(3-(4-(3-(piperidin-4-yl)propyl)piperidin-1-yl)propanamide)
  参考文献：
  名称：

  Oligo(amidoamine)s hydrogels with tunable gel properties

  摘要：

  一系列可根据pH和温度变化在溶解态和凝胶态之间可逆转换的聚酰胺胺寡聚物（OAAs）已被合成并表征。随着亚甲基单元数量的增加，它们的粘弹性显著增强，这表明在分子层面可以清晰地调节粘弹性。

  DOI：

  10.1039/c002169e
• 作为产物：
  描述：

  癸二胺 、 丙烯酰氯 在 三乙胺 作用下， 以 水 、 丙酮 为溶剂， 以50%的产率得到N,N'-(decane-1,10-diyl)diacrylamide
  参考文献：
  名称：

  pH-responsive polymeric micelle based on PEG-poly(β-amino ester)/(amido amine) as intelligent vehicle for magnetic resonance imaging in detection of cerebral ischemic area

  摘要：

  A series of pH-responsive polymeric micelles is developed to act as intelligent carriers to deliver iron oxide (Fe(3)O(4)) nanoparticles and respond rapidly to an acidic stimuli environment for magnetic resonance imaging (MRI). The polymeric micelle can be self-assembled at physiological pH by a block copolymer, consisting of a hydrophilic methoxy poly(ethylene glycol) (PEG) and a pH-responsive poly(beta-amino ester)/(amido amine) block. Consequently, the Fe(3)O(4) nanoparticles can be well encapsulated into polymeric micelles due to the hydrophobic interaction, shielded by a PEG corona! shell. In an acidic environment, however, the pH-responsive component, which has ionizable tert-amino groups on its backbone, can become protonated to be soluble and release the hydrophobic Fe(3)O(4) nanoparticles. The Fe(3)O(4)-loaded polymeric micelle was measured by dynamic light scattering (DLS), superconducting quantum interference device (SQUID) and a 3.0 T MRI scanner. To assess the ability of this MRI probe as a pH-triggered agent, we utilize a disease rat model of cerebral ischemia that produces acidic tissue due to its pathologic condition. We found gradual accumulation of Fe(3)O(4) nanoparticles in the brain ischemic area, indicating that the pH-triggered MRI probe may be effective for targeting the acidic environment and diagnostic imaging of pathologic tissue. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jconrel.2010.09.012

文献信息

• POLY(AMIDOAMINE) OLIGOMER HYDROGEL FOR DRUG DELIVERY AND DRUG CARRIER USING THE SAME
  申请人：LEE Doo Sung

  公开号：US20110217376A1

  公开（公告）日：2011-09-08

  Disclosed is a temperature- and pH-sensitive hydrogel composed of a poly(amidoamine) oligomer only. The hydrogel is prepared in a simple manner and is readily released from the body. Further disclosed are a method for preparing the hydrogel and a drug carrier using the hydrogel.

  本发明涉及一种由聚酰胺胺寡聚物组成的温度和pH敏感的水凝胶。该水凝胶制备简单，容易从体内释放。本发明还揭示了制备水凝胶的方法以及使用水凝胶的药物载体。
• Hydrogel contact lenses of high biocompatibility
  申请人：——

  公开号：US20020180927A1

  公开（公告）日：2002-12-05

  A hydrogel contact lens is described, the HEMA basic material of which is copolymerized with SPE and amino acids. The water retention capability and the refractive index of the resulting contact lens are similar to those of the natural cornea.

  描述了一种水凝胶隐形眼镜，其中HEMA基础材料与SPE和氨基酸共聚。得到的隐形眼镜的保水能力和折射率与天然角膜相似。
• Biocompatible polymers and co-polymers, and uses thereof
  申请人：Hitz Hans

  公开号：US20090232871A1

  公开（公告）日：2009-09-17

  The invention relates to highly biocompatible or biophilic un-cross-linked or cross-linked polymers comprising one or more side-chain active acrylic amino acids of formula I wherein: X is —NH(CH 2 ) 4 —, —O—C 6 H 4 —CH 2 —, —OCH 2 —, —O—CH(CH 3 )—, —S—CH 2 —, —O-proline, and R is H or CH 3 ; and wherein the polymer further includes a free radical initiator and, optionally, a cross-linking agent having a plurality of polymerizable ethylenically unsaturated groups. The invention further concerns various highly biocompatible, cross-linked co-polymers comprising one or more monomers of formula I, and one or more other polymerizable monomers. Uses of such polymers and co-polymers for the production of contact lenses, intraocular lenses, implants, wound healing slabs, additives for food and cosmetics, conductive plastics, spinnable fibers, and the like are disclosed.

  本发明涉及高生物相容性或亲生性的未交联或交联聚合物，其包括一个或多个侧链活性丙烯酸氨基酸（公式I），其中：X为—NH（CH2）4—，—O—C6H4—CH2—，—OCH2—，—O—CH（CH3）—，—S—CH2—，—O-脯氨酸，R为H或CH3；聚合物进一步包括自由基引发剂和可选的具有多个可聚合乙烯基不饱和基团的交联剂。本发明还涉及各种高生物相容性的交联共聚物，其中包括一个或多个公式I的单体和一个或多个其他可聚合单体。本发明还揭示了这些聚合物和共聚物的用途，用于生产隐形眼镜、人工晶体、植入物、伤口愈合垫、食品和化妆品添加剂、导电塑料、可旋转纤维等。
• Crosslinked polyvinylamine, polyallylamine, and polyethyleneimine for use as bile acid sequestrants
  申请人：Kopping Jordan

  公开号：US09181364B2

  公开（公告）日：2015-11-10

  The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.

  本发明提供了一种交联胺和酰胺聚合物，其有效地结合并去除胆汁盐从消化道。这些胆酸结合聚合物或其药物组成物可以用于治疗各种疾病，包括高胆固醇血症、糖尿病、瘙痒症、肠易激综合症-腹泻（IBS-D）、胆酸吸收不良等。
• Process for preparing 2-chlorosulfinyl-azetidinones
  申请人：ELI LILLY AND COMPANY

  公开号：EP0011370A1

  公开（公告）日：1980-05-28

  2-chlorosulfinyl-azetidin-4-ones of the formula wherein R is the residue of a carboxylic acid and R is a carboxylic acid protecting group, are prepared by reacting a penicillin sulfoxide ester of the formula wherein R and R1 are as defined above, with an N-chlorohalogenating agent, e.g. N-chlorophthalimide, in ar, inert organic solvent, e.g. toluene, under essentially anhydrous conditions in the presence of a cross-linked polyvinylpyridine polymer, e.g. poly-(4-vinylpyridine), said polymer containing between about 1 percent and about 10 percent cross-linking with e.g. divinylbenzene. The 2-chlorosulfinylazetidin-4-ones are used as intermediates for the preparation of 3-exomethylenecepham-4-carboxylic acid ester sulfoxides.

  式中的 2-氯亚磺酰基氮杂环丁烷-4-酮，其中 R 是羧酸残基，R 是羧酸保护基团。 式中 R 为羧酸残基、R 为羧酸保护基团的 2-氯亚磺酰基-氮杂环丁烷-4-酮，是由式中的青霉素亚砜酯与 N-氯卤化剂（如 N-氯酞酰亚胺）反应制备的。 其中 R 和 R1 如上定义，在 ar 惰性有机溶剂（如甲苯）中，在基本无水条件下，在交联聚乙烯吡啶聚合物（如聚-（4-乙烯基吡啶））存在下，与 N-氯卤化剂（如 N-氯邻苯二甲酰亚胺）反应，所述聚合物含有约 1%至约 10%的交联剂（如二乙烯基苯）。 2-chlorosulfinylazetidin-4-ones 可用作制备 3-exomethylenecepham-4-carboxylic acid ester sulfoxides 的中间体。