2,3,6-trimethylcarbazole | 78787-86-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2,3,6-trimethylcarbazole
• 英文别名: Carbazole, 2,3,6-trimethyl-；2,3,6-trimethyl-9H-carbazole
• CAS: 78787-86-7
• 化学式: C₁₅H₁₅N
• 分子量: 209.291
• InChiKey: BPIBYEJKQUCBHG-UHFFFAOYSA-N

物化性质

• 熔点：
  211-211.5 °C
• 沸点：
  401.9±14.0 °C(Predicted)
• 密度：
  1.132±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  15.8
• 氢给体数：
  1
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  3,4-二甲基苯肼 在 palladium on activated charcoal 作用下， 以 溶剂黄146 为溶剂， 反应 8.0h， 生成 2,3,6-trimethylcarbazole
  参考文献：
  名称：

  Kuroki, Masanate; Tsunashima, Yutaka, Journal of Heterocyclic Chemistry, 1981, vol. 18, p. 709 - 714

  摘要：

  DOI：

文献信息

• Synthesis of carbazoles and dibenzofurans via cross-coupling of o-iodoanilines and o-iodophenols with silylaryl triflates and subsequent Pd-catalyzed cyclization
  作者：Zhijian Liu、Richard C. Larock

  DOI：10.1016/j.tet.2006.10.071

  日期：2007.1

  An efficient route to a variety of carbazoles and dibenzofurans has been developed. It involves the reaction of o-iodoanilines or o-iodophenols with silylaryl triflates in the presence of CsF to afford the N- or O-arylated products, which are subsequently cyclized using a Pd catalyst to carbazoles and dibenzofurans in good to excellent yields. By using this methodology, the carbazole alkaloid, mukonine has been synthesized in 76% overall yield in three steps. (c) 2006 Elsevier Ltd. All rights reserved.
• KUROKI, MASATANE;TSUNASHIMA, YUTAKA, J. HETEROCYCL. CHEM., 1981, 18, N 4, 709-714
  作者：KUROKI, MASATANE、TSUNASHIMA, YUTAKA

  DOI：——

  日期：——
• Kuroki, Masanate; Tsunashima, Yutaka, Journal of Heterocyclic Chemistry, 1981, vol. 18, p. 709 - 714
  作者：Kuroki, Masanate、Tsunashima, Yutaka

  DOI：——

  日期：——