5-(3-Methyl-6-oxocyclohexa-2,4-dien-1-ylidene)proline | 262266-68-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-(3-Methyl-6-oxocyclohexa-2,4-dien-1-ylidene)proline
• 英文别名: 5-(2-hydroxy-5-methylphenyl)-3,4-dihydro-2H-pyrrole-2-carboxylic acid
• CAS: 262266-68-2
• 化学式: C₁₂H₁₃NO₃
• 分子量: 219.24
• InChiKey: NTQBXVPEDYGKKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  69.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Method and composition for treatment of inflammatory bowel disease
  申请人：——

  公开号：US20030211978A1

  公开（公告）日：2003-11-13

  A composition in unit dosage form for the inhibition, prevention or treatment of inflammatory bowel disease comprising an effective amount of a compound having the formula: 1 and a pharmaceutically acceptable carrier therefor. Also disclosed is a method for the inhibition, prevention or treatment of inflammatory bowel disease comprising administering to a human or non-human mammal in need thereof an effective amount of a compound having the formula: 2

  一种单剂量制剂，用于抑制、预防或治疗炎症性肠病，包括一种有效量的具有以下公式的化合物和其药学可接受载体。还公开了一种用于抑制、预防或治疗炎症性肠病的方法，包括向需要的人类或非人类哺乳动物投与有效量的具有以下公式的化合物。
• Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin
  申请人：University of Florida

  公开号：US20040044220A1

  公开（公告）日：2004-03-04

  Free radicals and reactive oxygen species have the potential to damage a wide variety of organic molecules, typically by oxidizing certain moieties. These damaging species can, for example, be produced by an organism as a by-product of cellular respiration or by the reaction of iron(II) and peroxide. The present invention includes methods of using aryl-substituted heterocyclic iron chelating compounds as antioxidants, as well as preventing the reduction of iron(III) to iron(II). In addition, the present invention provides methods of treating conditions such as inflammatory disease, neoplastic disease, and ischemic episodes.

  自由基和反应性氧化物具有损坏各种有机分子的潜力，通常通过氧化某些官能团来实现。这些有害的物质可以由生物体作为细胞呼吸的副产品产生，也可以由铁（II）和过氧化物的反应产生。本发明包括使用芳基取代的杂环铁螯合化合物作为抗氧化剂的方法，以及防止铁（III）还原为铁（II）的方法。此外，本发明还提供了治疗炎症性疾病、肿瘤性疾病和缺血发作的方法。
• US6159983A
  申请人：——

  公开号：US6159983A

  公开（公告）日：2000-12-12
• US6689788B1
  申请人：——

  公开号：US6689788B1

  公开（公告）日：2004-02-10
• [EN] METHOD AND COMPOSITION FOR TREATMENT OF INFLAMMATORY BOWEL DISEASE<br/>[FR] METHODE DE TRAITEMENT DE L'AFFECTION INTESTINALE INFLAMMATOIRE ET COMPOSITION A CET EFFET
  申请人：——

  公开号：WO2000016765A9

  公开（公告）日：2000-10-05

  [EN] A composition in unit dosage form for the inhibition, prevention or treatment of inflammatory bowel disease comprising an effective amount of a compound having formula (A): and a pharmaceutically acceptable carrier therefor. Also disclosed is a method for the inhibition, prevention or treatment of inflammatory bowel disease comprising administering to a human or non-human mammal in need thereof an effective amount of a compound having formula (B).
  [FR] Cette composition sous forme posologique unitaire, destinée à l'inhibition, la prévention ou le traitement de l'affection intestinale inflammatoire, renferme une quantité efficace d'un composé correspondant à la formule (A) ainsi qu'un excipient acceptable du point de vue pharmaceutique. L'invention a également trait à une méthode, permettant d'inhiber, de prévenir ou de traiter l'affection intestinale inflammatoire, consistant à administrer à un mammifère, humain ou non, exigeant un tel traitement, une quantité efficace d'un composé correspondant à la formule (B).