2-(4-ethoxyphenylamino)ethanol | 2933-80-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(4-ethoxyphenylamino)ethanol
• 英文别名: 2-p-Phenetidino-aethanol；2-p-phenetidino-ethanol；4-(β-Oxy-aethylamino)-phenetol；(β-Oxy-aethyl)-p-phenetidin；β-p-Phenetidino-aethylalkohol；2-(4-Ethoxyanilino)ethanol
• CAS: 2933-80-4
• 化学式: C₁₀H₁₅NO₂
• 分子量: 181.235
• InChiKey: WXZDYTGISAQXNB-UHFFFAOYSA-N

物化性质

• 熔点：
  50-51 °C
• 沸点：
  150-155 °C(Press: 1 Torr)
• 密度：
  1.109±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  41.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(4-ethoxyphenylamino)ethanol 在 吡啶 、 盐酸 作用下， 生成 1-benzoyloxy-2-(N-methyl-p-phenetidino)-ethane
  参考文献：
  名称：

  Bergmann; Ulpts; Camacho, Chemische Berichte, 1922, vol. 55, p. 2806

  摘要：

  DOI：
• 作为产物：
  描述：

  对乙氧基苯胺 在 alkaline solution 、 苯 作用下， 生成 2-(4-ethoxyphenylamino)ethanol
  参考文献：
  名称：

  Adams; Segur, Journal of the American Chemical Society, 1923, vol. 45, p. 789

  摘要：

  DOI：

文献信息

• DE382693
  申请人：——

  公开号：——

  公开（公告）日：——
• BmimOAc ionic liquid: A highly efficient catalyst for synthesis of 3-aryl-2-oxazolidinones by direct condensation of 2-(arylamino) alcohols with diethyl carbonate
  作者：Elnazeer H.M. Elageed、Binshen Wang、Yongya Zhang、Shi Wu、Guohua Gao

  DOI：10.1016/j.molcata.2015.07.034

  日期：2015.11

  An efficient convenient procedure for the synthesis of 3-aryl-2-oxazolidinones from 2-(arylamino) alcohols and diethyl carbonate (DEC) catalyzed by ionic liquids is described. The effects of reaction time, amount of catalyst and temperature were investigated. Excellent yields of products were obtained under the optimized reaction conditions, when using BmimOAc as a catalyst. An intermediate ethyl 2-(phenyl amino) ethyl carbonate was isolated and characterized. H-1 NMR spectroscopy and DFT calculations indicated that BmimOAc cooperatively activate the substrates through hydrogen bonding with its anion and cation sites. According to these results, a possible reaction mechanism was discussed. (C) 2015 Elsevier B.V. All rights reserved.
• Lewis acids catalyzed ring-opening reactions of methylenecyclopropanes and epoxides in supercritical carbon dioxide or modified supercritical carbon dioxide with perfluorocarbon
  作者：Min Shi、Yu Chen

  DOI：10.1016/s0022-1139(03)00083-6

  日期：2003.8

  The reactions of methylenecyclopropanes (MCPs) and epoxides with alcohols and aromatic amines can be carried out in supercritical carbon dioxide (scCO(2)) or modified scCO(2) with perfluorocarbon which offer a way to synthesize various alcohols, amino-alcohols, homoallylic ethers, and amines under an environmentally benign condition. (C) 2003 Elsevier Science B.V. All rights reserved.
• DE503134
  申请人：——

  公开号：——

  公开（公告）日：——
• DE414259
  申请人：——

  公开号：——

  公开（公告）日：——