8-nonynoic acid ethyl ester | 108545-40-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 8-nonynoic acid ethyl ester
• 英文别名: ethyl non-8-ynoate
• CAS: 108545-40-0
• 化学式: C₁₁H₁₈O₂
• 分子量: 182.263
• InChiKey: VQUNQQSFRSCJAO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  8-nonynoic acid ethyl ester 在 sulfur 、 三乙胺 、 1,1'-偶氮(氰基环己烷) 作用下， 以 苯 为溶剂， 反应 10.0h， 生成 ethyl (E)-8,9-bis(diphenylthiophosphinyl)-8-nonenoate
  参考文献：
  名称：

  通过自由基加成原位生成的四有机二膦烷烃，从炔烃中合成（E）-1,2-二膦基蒽衍生物。

  摘要：

  DOI：

  10.1002/anie.200462603
• 作为产物：
  描述：

  8-壬酸甲酯 在 氢氧化钾 、 硫酸 作用下， 反应 0.5h， 生成 8-nonynoic acid ethyl ester
  参考文献：
  名称：

  Synthesis and Biological Activities of Acetylenic Fatty Acids and Their Esters

  摘要：

  通过邻硝基苯硒醚合成了 8 种末端炔脂肪酸:从 5-己炔酸到 12-十三炔酸及其甲基、乙基和异丙基酯。这些酸和酯对莴苣种子萌发和幼苗生长均有抑制作用。其作用效果依赖于炔链碳原子数。8-壬炔酸具有强烈的活性,其甲酯在所测试样品中活性最强。此外,这些酸具有抗菌活性,且随碳原子数的增加而增强。

  DOI：

  10.1246/bcsj.59.3535

文献信息

• [EN] FATTY ACID DERIVATIVES FOR TREATING NON-ALCOHOLIC STEATOHEPATITIS<br/>[FR] DÉRIVÉS D'ACIDE GRAS POUR LE TRAITEMENT DE LA STÉATOHÉPATITE NON ALCOOLIQUE
  申请人：BASF AS

  公开号：WO2019111048A1

  公开（公告）日：2019-06-13

  The present disclosure provides a compound for use in therapeutic and/or prophylactic treatment of non-alcoholic steatohepatitis (NASH) and/or alcoholic steatohepatitis (ASH). The compound for use according to the invention, is an unsaturated fatty acid with an oxygen incorporated in the β-position, and further comprising an α-substituent. More particularly, the invention provides a compound for use in treatment of NASH and/or ASH, and a method using this, wherein the compound is of Formula (II), wherein R1, R2, R3, X, and Y are as defined in the specification; and wherein this compound may be administered alone or in combination with an additional active agent.

  本公开提供了一种用于治疗和/或预防非酒精性脂肪肝炎（NASH）和/或酒精性脂肪肝炎（ASH）的化合物。根据本发明使用的化合物是一种在β位含有氧原子的不饱和脂肪酸，并且还包含一个α-取代基。更具体地说，本发明提供了一种用于治疗NASH和/或ASH的化合物以及使用该方法，其中该化合物是公式（II），其中R1、R2、R3、X和Y如说明书中所定义；并且该化合物可以单独使用或与另一种活性剂结合使用。
• Efficient Pd(0)-Catalyzed Hydrosilylation of Alkynes with Triorganosilanes
  作者：Koichiro Oshima、Dai Motoda、Hiroshi Shinokubo

  DOI：10.1055/s-2002-33535

  日期：——

  An electron-rich Pd(0) complex, a Pd 2 (dba) 3 .CHCl 3 -tri-cyclohexylphosphine combination catalyzes highly efficient hydrosilylation of alkynes at room temperature with Ph 3 SiH or Ph 2 MeSiH without solvents. The regioselectivity of this process is higher than that with the conventional Pt(0)-catalyzed hydrosilylation.

  一种富含电子的 Pd(0) 络合物，即 Pd 2 (dba) 3 .CHCl 3 -三环己基膦组合，在室温下用 Ph 3 SiH 或 Ph 2 MeSiH 在没有溶剂的情况下催化炔烃的高效氢化硅烷化。该过程的区域选择性高于传统的 Pt(0) 催化氢化硅烷化。
• Copper-Catalyzed anti-Hydrophosphination Reaction of 1-Alkynylphosphines with Diphenylphosphine Providing (<i>Z</i>)-1,2-Diphosphino-1-alkenes
  作者：Azusa Kondoh、Hideki Yorimitsu、Koichiro Oshima

  DOI：10.1021/ja070048d

  日期：2007.4.1

  nes and their sulfides. The reaction is highly chemoselective and can be performed even in an aqueous medium. The reaction is reliable enough to realize a gram-scale synthesis of (Z)-1,2-diphosphino-1-alkene. Radical reduction of the diphosphine disulfides with tris(trimethylsilyl)silane yields the parent trivalent diphosphines without suffering from the isomerization of the olefinic geometry. Enantioselective

  1-炔基膦与二苯基膦的氢膦化反应在铜催化下以反方式进行，为获得各种 (Z)-1,2-二膦基-1-烯烃及其硫化物提供了一种简单有效的途径。该反应具有高度化学选择性，甚至可以在水性介质中进行。该反应足够可靠，可以实现 (Z)-1,2-diphosphino-1- 烯烃的克级合成。用三(三甲基甲硅烷基)硅烷对二硫化二膦进行自由基还原产生母体三价二膦，而不会发生烯烃几何异构化。(Z)-3,3-二甲基-1,2-双(二苯基硫代膦基)-1-丁烯的对映选择性氢化，然后脱硫产生新的手性双齿膦配体。
• <i>Trans</i>-Hydrometalation of Alkynes by a Combination of InCl₃ and DIBAL-H:  One-Pot Access to Functionalized <i>(Z)</i>-Alkenes
  作者：Kazuaki Takami、Hideki Yorimitsu、Koichiro Oshima

  DOI：10.1021/ol026401w

  日期：2002.8.1

  Triethylborane-induced hydrometalation of alkynes proceeds in an anti manner to afford the corresponding (Z)-alkenylmetal compounds stereoselectively, where dichloroindium hydride would play a key role. A variety of functional groups including hydroxy, carbonyl, and carboxy groups were tolerant under the reaction conditions. Following iodolysis and cross-coupling reaction of the (Z)-alkenylmetal species show the usefulness of this strategy.
• Triethylborane-Mediated Hydrogallation and Hydroindation:  Novel Access to Organogalliums and Organoindiums
  作者：Kazuaki Takami、Satoshi Mikami、Hideki Yorimitsu、Hiroshi Shinokubo、Koichiro Oshima

  DOI：10.1021/jo0344790

  日期：2003.8.1

  Hydrogallation of carbon-carbon multiple bonds proceeds in the presence of triethylborane as a radical initiator. Several functionalities do not interfere with this reaction. Resulting alkenyl- and alkylgallium species can be trapped by several electrophiles. Highly regioselective radical addition of an indium hydride reagent to alkynes is also achieved. Various functionalities are tolerant under the reaction conditions. The reaction proceeds with complete anti stereoselectivity. Alkenylindiums obtained via hydroindation can be employed for the following cross-coupling reaction with aryl halides in one pot.