2-(6-methylpyridin-2-yl)-N,N-diphenylacetamide | 1000016-40-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(6-methylpyridin-2-yl)-N,N-diphenylacetamide
• CAS: 1000016-40-9
• 化学式: C₂₀H₁₈N₂O
• 分子量: 302.376
• InChiKey: BHPDYIFKJIKXMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  33.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(6-methylpyridin-2-yl)-N,N-diphenylacetamide 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以57%的产率得到2-hydroxy-2-(6-methyl-1-oxy-pyridin-2-yl)-N,N-diphenylacetamide
  参考文献：
  名称：

  Oxidation Reactivity Channels for 2-(Pyridin-2-yl)-N,N-diphenylacetamides

  摘要：

  [Graphics]Synthetic routes to 2-(pyridin-2-yl)-N,N-diphenylacetamide and 2-(6-methylpyridin-2-yl)-N,N-diphenylacetamide are described along with results from the chemical oxidation of these compounds with peracetic acid, m-chloroperbenzoic acid, and OXONE. In each case, oxidations generate four products in varying amounts depending on the oxidant and reaction conditions. Each product has been characterized by spectroscopic methods and the molecular structures of several of the new compounds have been confirmed by X-ray crystallography.

  DOI：

  10.1021/jo701408y
• 作为产物：
  描述：

  2,6-二甲基吡啶 、 二苯氨基甲酰氯 在 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 以70%的产率得到2-(6-methylpyridin-2-yl)-N,N-diphenylacetamide
  参考文献：
  名称：

  Oxidation Reactivity Channels for 2-(Pyridin-2-yl)-N,N-diphenylacetamides

  摘要：

  [Graphics]Synthetic routes to 2-(pyridin-2-yl)-N,N-diphenylacetamide and 2-(6-methylpyridin-2-yl)-N,N-diphenylacetamide are described along with results from the chemical oxidation of these compounds with peracetic acid, m-chloroperbenzoic acid, and OXONE. In each case, oxidations generate four products in varying amounts depending on the oxidant and reaction conditions. Each product has been characterized by spectroscopic methods and the molecular structures of several of the new compounds have been confirmed by X-ray crystallography.

  DOI：

  10.1021/jo701408y