O-(5-Methylisoxazol-3-yl)methylhydroxylamine hydrochloride | 156233-51-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: O-(5-Methylisoxazol-3-yl)methylhydroxylamine hydrochloride
• 英文别名: 3-[(aminooxy)methyl]-5-methylisoxazole hydrochloride；O-[(5-methyl-1,2-oxazol-3-yl)methyl]hydroxylamine;hydrochloride
• CAS: 156233-51-1
• 化学式: C₅H₈N₂O₂*ClH
• 分子量: 164.592
• InChiKey: UTIQTQMOIGMRFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  61.3
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  O-(5-Methylisoxazol-3-yl)methylhydroxylamine hydrochloride 、 Ph(3-Cl)(5-OCF3)-(R)CH(OH)C(O)-Aze-Pab(Teoc) 在 三氟乙酸 作用下， 以 乙腈 、 二氯甲烷 为溶剂， 反应 3.0h， 以35%的产率得到Ph(3-Cl)(5-OCF3)-(R)CH(OH)C(O)-Aze-Pab(OCH2-3-(5-Me-isoxazole))
  参考文献：
  名称：

  [EN] PHARMACEUTICAL COMBINATION
  [FR] COMBINAISON PHARMACEUTIQUE

  摘要：

  提供了一种组合产品，包括：(1) WO 02/44145中权利要求1的化合物或WO 02/44145中权利要求20的化合物（或其衍生物）或药用可接受的衍生物；以及（1）WO 01/28992中权利要求1定义的化合物或（2）WO 01/28992中权利要求34的化合物或（3）化合物A或B或C或D（或药用可接受的盐）用于治疗心律不齐或其凝血控制的并发症。

  公开号：

  WO2003101956A1

文献信息

• Mandelic acid derivatives and their use as throbin inhibitors
  申请人：——

  公开号：US20040019033A1

  公开（公告）日：2004-01-29

  There is provided a compound of formula I 1 wherein R a , R 1 , R 2 , Y and R 3 have meanings given in the description and pharmaceutically acceptable derivatives (including prodrugs) thereof, which compounds and derivatives are useful as, or are useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.

  提供了一种公式I的化合物 1 其中R a , R 1 , R 2 , Y和R 3 具有说明书中给出的含义以及药学上可接受的衍生物（包括前药），这些化合物和衍生物可用作竞争性胰蛋白酶样蛋白酶抑制剂，如凝血酶，因此，特别是用于需要抑制凝血酶的情况（例如血栓形成）或作为抗凝剂。
• New amidino derivatives and their use as thormbin inhibitors
  申请人：——

  公开号：US20020068730A1

  公开（公告）日：2002-06-06

  There is provided compounds of formula I, 1 wherein Y and R 1 have meanings given in the description, and pharmaceutically acceptable derivatives (including prodrugs) thereof, which compounds and derivatives are useful as, or are useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.

  提供了化合物I，其中Y和R1的含义如描述中所述，并且其药学上可接受的衍生物（包括前药），这些化合物和衍生物在竞争性蛋白酶酶类（如凝血酶）的抑制剂方面具有用处，因此特别适用于治疗需要抑制凝血酶的情况（例如血栓形成）或作为抗凝剂。
• Pharmaceutical combination
  申请人：Roth-Rosendahl Ann-Charlotte

  公开号：US20060052314A1

  公开（公告）日：2006-03-09

  There is provided a combination product comprising: (1) a compound of claim 1 in WO 02/44145 or a compound of claim 20 in WO 02/44145 (or derivateive thereof) or a pharmaceutically-acceptable derivative thereof; and (1) a compound as defined in claim 1 or WO 01/28993 or (2) compound of claim 34 or WO 01/28992 or (3) Compound A or B or C or D (or pharmaceutically-acceptable salts therof) for use in treating arrhythmia or a coagulation controlled complicaiton thereof.

  提供了一种组合产品，包括：（1）WO 02/44145中权利要求1的化合物或权利要求20的化合物（或其衍生物）或其药学上可接受的衍生物；和（2）权利要求1或WO 01/28993中定义的化合物或（3）权利要求34或WO 01/28992中的化合物A或B或C或D（或其药学上可接受的盐），用于治疗心律失常或其凝血控制并发症。
• New mandelic acid derivatives and their use as thrombin inhibitors
  申请人：Inghardt Tord

  公开号：US20070218136A1

  公开（公告）日：2007-09-20

  There is provided a compound of formula (I) wherein R a , R 1 , R 2 , Y and R 3 have meanings given in the description and pharmaceutically-acceptable derivatives (including prodrugs) thereof, which compounds and derivatives are useful as, or are useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is required (e.g., thrombosis) or as anticoagulants.

  提供了一种化合物，其化学式为（I），其中Ra，R1，R2，Y和R3具有描述中给出的含义以及其药物可接受的衍生物（包括前药），这些化合物和衍生物可用作竞争性蛋白酶抑制剂，如凝血酶，因此特别用于治疗需要抑制凝血酶的情况（例如血栓形成）或作为抗凝剂。
• Mandelic acid derivatives and their use as thrombin inhibitors
  申请人：Inghardt Tord

  公开号：US20080090800A1

  公开（公告）日：2008-04-17

  There is provided a compound of formula (I) wherein R a , R 1 , R 2 , Y and R 3 have meanings given in the description and pharmaceutically-acceptable derivatives (including prodrugs) thereof, which compounds and derivatives are useful as, or are useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is required (e.g., thrombosis) or as anticoagulants.

  提供了一个化合物的公式（I），其中Ra，R1，R2，Y和R3具有描述中给出的含义，以及其药学上可接受的衍生物（包括前药），这些化合物和衍生物可用作具有竞争性的胰蛋白酶类蛋白酶抑制剂的作用，例如凝血酶，因此特别适用于治疗需要抑制凝血酶的情况（例如血栓形成）或作为抗凝剂。