1-bromo-3-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzene | 318261-63-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-bromo-3-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzene
• 英文别名: 1-Bromo-3-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]benzene；1-bromo-3-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]benzene
• CAS: 318261-63-1
• 化学式: C₁₃H₁₉BrO₄
• 分子量: 319.195
• InChiKey: AOAZXZSHYHNADR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  18
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-bromo-3-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzene 在 四氮唑 、 正丁基锂 作用下， 以 乙醚 、 正己烷 、 乙腈 为溶剂， 反应 21.0h， 生成 bis(2-methoxyethyl) (3-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)phosphonite
  参考文献：
  名称：

  Staudinger-Phosphonite Reactions for the Chemoselective Transformation of Azido-Containing Peptides and Proteins

  摘要：

  Site-specific functionalization of proteins by bloorthogonal modification offers a convenient pathway to create, modify, and study biologically active biopolymers. In this paper the Staudinger reaction of aryl-phosphonites for the chemoselective functionalization of azido-peptides and proteins was probed. Different water-soluble phosphonites with ollgoethylene substituents were synthesized and reacted with unprotected azido-containing peptides in aqueous systems at room temperature in high conversions. Finally, the Staudinger-phosphonite reaction was successfully applied to the site-specific modification of the protein calmodulin.

  DOI：

  10.1021/ol2020175
• 作为产物：
  描述：

  三甘醇单甲醚 在 三甲胺盐酸盐 、 potassium carbonate 、 三乙胺 作用下， 以 乙腈 为溶剂， 反应 19.5h， 生成 1-bromo-3-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzene
  参考文献：
  名称：

  Staudinger-Phosphonite Reactions for the Chemoselective Transformation of Azido-Containing Peptides and Proteins

  摘要：

  Site-specific functionalization of proteins by bloorthogonal modification offers a convenient pathway to create, modify, and study biologically active biopolymers. In this paper the Staudinger reaction of aryl-phosphonites for the chemoselective functionalization of azido-peptides and proteins was probed. Different water-soluble phosphonites with ollgoethylene substituents were synthesized and reacted with unprotected azido-containing peptides in aqueous systems at room temperature in high conversions. Finally, the Staudinger-phosphonite reaction was successfully applied to the site-specific modification of the protein calmodulin.

  DOI：

  10.1021/ol2020175

文献信息

• [EN] MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE<br/>[FR] INHIBITEURS DE MCL-1 MACROCYCLIQUE ET PROCÉDÉS D'UTILISATION
  申请人：ABBVIE INC

  公开号：WO2019035927A1

  公开（公告）日：2019-02-21

  The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).

  本公开提供了Formula (I)中A2、A3、A4、A6、A7、A8、A15、RA、R5、R9、R10A、R10B、R11、R12、R13、R14、R16、W、X和Y的化合物，这些化合物的任何值均在规范中定义，并且其药学上可接受的盐，可用作治疗疾病和病况，包括癌症的药物。还提供了包含Formula (I)中化合物的药物组合物。
• Ｎ，Ｎ，Ｎ′，Ｎ′−テトラフェニルベンジジン化合物
  申请人：日産化学株式会社

  公开号：JP2020040962A

  公开（公告）日：2020-03-19

  【課題】陽極と発光層との間にそれらと接する態様で単一層として用いた場合でも、優れた輝度特性を有する有機ＥＬ素子を実現できる薄膜を与える電荷輸送性ワニスに適したフッ素原子を含有する重合体の原料となる、Ｎ，Ｎ，Ｎ′，Ｎ′−テトラフェニルベンジジン化合物の提供。【解決手段】式（９−１）で示されるＮ，Ｎ，Ｎ′，Ｎ′−テトラフェニルベンジジン化合物。（Ｚ2は、エーテル結合を含んでいてもよいＣ１〜Ｃ２０のアルコキシ基；但し、Ｚ2がアミノ基のパラ位に置換されたメトキシ基又はｎ−オクチルオキシ基の場合を除く。）【選択図】なし

  【问题】提供一种可用于作为单层在阳极和发光层之间与其接触时具有优良亮度特性的有机EL器件的薄膜的原料，其中适用于含有含氟原子的聚合物的电荷传输性树脂的N，N，N'，N'-四苯基联苯胺化合物。【解决手段】如式（9-1）所示的N，N，N'，N'-四苯基联苯胺化合物。（其中，Z2可以是含有醚键的C1-C20的烷氧基；但不包括Z2被氨基取代的对位甲氧基或n-辛氧基的情况。）【选择图】无
• CHARGE-TRANSPORTING VARNISH
  申请人：Nissan Chemical Industries, Ltd.

  公开号：EP3124563A1

  公开（公告）日：2017-02-01

  This charge-transporting varnish includes: a fluorine-containing charge-transporting substance; a non-fluorine-containing charge-transporting substance; a dopant substance comprising a heteropoly acid; and an organic solvent. The fluorine-containing charge-transporting substance is a polymer which has a weight average molecular weight of 500-200,000, and which is obtained by condensing: at least one compound selected from triarylamine compounds and tetraarylbenzidine compounds; a tetraarylbenzidine compound having at least one aryl group substituted with an alkoxy group which may include ether bonds; a fluorine-containing aryl aldehyde compound; and a fluorene derivative having a carbonyl group. The non-fluorine-containing charge-transporting substance is an oligoaniline compound. The charge-transporting varnish provides a thin film with which an organic electroluminescent element exhibiting excellent luminance characteristics can be achieved, even in cases when employed as a single layer in a state of being provided between and in contact with a positive electrode and a light-emission layer.

  这种电荷传输清漆包括：一种含氟电荷传输物质；一种不含氟的电荷传输物质；一种包含杂多酸的掺杂物质；以及一种有机溶剂。含氟电荷传输物质是一种重量平均分子量为 500-200000 的聚合物，由以下物质缩合而成：至少一种选自三芳基胺化合物和四芳基联苯胺化合物的化合物；至少一个芳基被烷氧基取代的四芳基联苯胺化合物，烷氧基可包括醚键；含氟芳基醛化合物；以及具有羰基的芴衍生物。不含氟的电荷传输物质是一种低聚苯胺化合物。电荷传输清漆提供了一种薄膜，利用这种薄膜可以实现有机电致发光元件的卓越发光特性，即使在作为单层使用时，也可以在正电极和发光层之间提供并与之接触。
• Solvophobically Driven π-Stacking of Phenylene Ethynylene Macrocycles and Oligomers
  作者：Shreyasi Lahiri、Julie L. Thompson、Jeffrey S. Moore

  DOI：10.1021/ja002129e

  日期：2000.11.22

  Phenylene ethynylene macrocycles and oligomers with three different side-chain linking groups (ester, benzyl ether, and phenyl ether) were synthesized to investigate their tendency to undergo solvent induced pi -stacked organization. H-1 NMR, UV, and fluorescence spectroscopies were used to probe two types of pi -stacked supramolecular organizations: the intramolecular conformational ordering of the oligomers, and the intermolecular aggregation of the macrocycles. One important conclusion is that solvent can play a very dramatic role in modulating the strength of the interactions that drive the association of these ct-stacked structures. The other important conclusion is that in a given solvent, the nature of the side chain linking group strongly influences the pi -stacking propensities. It was found that macrocycles and oligomers with the ether side chain linking group were prone to adopt pi -stacked structures in a range of solvents, whereas the corresponding macrocycles with benzyl ether and phenyl ether side chain linking groups showed only limited ability to pi -stack, even in the most polar solvent examined (DMSO). In the interest of manipulating the helix-coil folding transition of phenylene ethynylene oligomers, a heterosequence consisting of monomers with ester and benzyl ether side chain linkages was synthesized. The folding transition of the heterooligomer was intermediate to that observed for the corresponding homooligomers, suggesting that the backbone sequence can be used to tune the stability of conformations that are based on pi -stacked organizations.
• MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE
  申请人：AbbVie Inc.

  公开号：EP3668502A1

  公开（公告）日：2020-06-24