phenyl thiazolo[5,4-b]pyridin-2-ylcarbamate | 50621-23-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: phenyl thiazolo[5,4-b]pyridin-2-ylcarbamate
• 英文别名: phenyl N-([1,3]thiazolo[5,4-b]pyridin-2-yl)carbamate
• CAS: 50621-23-3
• 化学式: C₁₃H₉N₃O₂S
• 分子量: 271.299
• InChiKey: CFUSSKJAZITARS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  92.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-氨基-4-甲基嘧啶 、 phenyl thiazolo[5,4-b]pyridin-2-ylcarbamate 以 甲苯 为溶剂， 反应 20.0h， 以54%的产率得到1-(4-Methylpyrimidin-2-yl)-3-([1,3]thiazolo[5,4-b]pyridin-2-yl)urea
  参考文献：
  名称：

  A New Method for Synthesizing Asymmetric Urea Containing Thiazolo[5,4-b]pyridine And Applications in Agriculture

  摘要：

  In this article, we describe the use of diphenyl carbonate (DPC) as a carbonyl source instead of isocyanate to synthesize asymmetric substituted urea derivatives. In a study aiming to discover new lead compounds with agricultural activities, thiazole[5,4-b]pyridine ureas were prepared by this method and characterized by mass spectrometry, elemental analysis, and H-1 NMR spectroscopy. The biological activities show that the title compounds have moderate activities on herbicide, fungicide, and plant growth regulation.

  DOI：

  10.1080/10426507.2010.497518
• 作为产物：
  描述：

  3-氨基-2-氯吡啶 在 硫酸 、 水 、 sodium methylate 、 sodium hydride 作用下， 以 四氢呋喃 、 N-甲基吡咯烷酮 、 丙酮 为溶剂， 反应 16.0h， 生成 phenyl thiazolo[5,4-b]pyridin-2-ylcarbamate
  参考文献：
  名称：

  A New Method for Synthesizing Asymmetric Urea Containing Thiazolo[5,4-b]pyridine And Applications in Agriculture

  摘要：

  In this article, we describe the use of diphenyl carbonate (DPC) as a carbonyl source instead of isocyanate to synthesize asymmetric substituted urea derivatives. In a study aiming to discover new lead compounds with agricultural activities, thiazole[5,4-b]pyridine ureas were prepared by this method and characterized by mass spectrometry, elemental analysis, and H-1 NMR spectroscopy. The biological activities show that the title compounds have moderate activities on herbicide, fungicide, and plant growth regulation.

  DOI：

  10.1080/10426507.2010.497518

文献信息

• A New Method for Synthesizing Asymmetric Urea Containing Thiazolo[5,4-b]pyridine And Applications in Agriculture
  作者：Wenbin Chen、Kejian Li

  DOI：10.1080/10426507.2010.497518

  日期：2011.1.31

  In this article, we describe the use of diphenyl carbonate (DPC) as a carbonyl source instead of isocyanate to synthesize asymmetric substituted urea derivatives. In a study aiming to discover new lead compounds with agricultural activities, thiazole[5,4-b]pyridine ureas were prepared by this method and characterized by mass spectrometry, elemental analysis, and H-1 NMR spectroscopy. The biological activities show that the title compounds have moderate activities on herbicide, fungicide, and plant growth regulation.