(S)-2-amino-6-(((1R,2R)-2-azidocyclopentyloxy)carbonylamino)hexanoic acid | 1304056-21-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-2-amino-6-(((1R,2R)-2-azidocyclopentyloxy)carbonylamino)hexanoic acid
• 英文别名: (2S)-2-amino-6-[[(1R,2R)-2-azidocyclopentyl]oxycarbonylamino]hexanoic acid
• CAS: 1304056-21-0
• 化学式: C₁₂H₂₁N₅O₄
• 分子量: 299.33
• InChiKey: JYEVZNBYATWOFD-IVZWLZJFSA-N

物化性质

• 溶解度：
  溶于二甲基亚砜

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  21
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  116
• 氢给体数：
  3
• 氢受体数：
  7

制备方法与用途

生物活性方面，ACPK 是一种类似于吡咯赖氨酸的化合物，并且含有叠氮基团。

反应信息

• 作为产物：
  描述：

  1,2-环氧环戊烷 在 盐酸 、 (1S,2S)-(-)-[1,2-cyclohexanediamino-N,N′-bis(3,5-di-t-butylsalicylidene)]chromium(III) chloride 、 碳酸氢钠 、 三氟乙酸 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 水 为溶剂， 反应 44.67h， 生成 (S)-2-amino-6-(((1R,2R)-2-azidocyclopentyloxy)carbonylamino)hexanoic acid
  参考文献：
  名称：

  一种易于合成的环状吡咯赖氨酸类似物，用于位点特异性蛋白质“点击”标记。

  摘要：

  开发了一种简便的方法，可轻松合成带有叠氮手柄的环状吡咯赖氨酸类似物。定向进化能够在原核和真核细胞中对该非天然氨基酸进行编码，这为使用点击化学进行位点特异性蛋白质标记提供了一种高效的方法。

  DOI：

  10.1039/c1cc00024a

文献信息

• Adeno-Associated Virus with Site-Directed Mutagenesis and Site-Directed Modification and Preparation Method and Application Thereof
  申请人：PEKING UNIVERSITY

  公开号：US20160297855A1

  公开（公告）日：2016-10-13

  The present invention relates to an adeno-associated virus with site-directed mutagenesis and site-specific modification, and a preparation method and uses thereof. Specifically, the present invention uses genetic code expansion techniques to incorporate non-natural amino acid into an adeno-associated virus capsid protein VP1 or fragment thereof, thereby obtaining an adeno-associated virus with site-directed mutagenesis using the non-natural amino acid. The adeno-associated virus with site-directed mutagenesis is equivalent to a wild-type virus in terms of production, transduction and mobility, can couple with other functional molecules, such as targeting molecules, and can carry a functional gene in a normal manner, which indicates that the adeno-associated virus with site-directed mutagenesis can be used as a tool adeno-associated virus, and applied in various aspects associated with adeno-associated virus such as finding adeno-associated virus binding proteins or using as target genetic therapy vector.
• OLIGONUCLEOTIDE-TETHERED NUCLEOTIDES
  申请人：THERMO FISHER SCIENTIFIC BALTICS UAB

  公开号：US20200399633A1

  公开（公告）日：2020-12-24

  The present disclosure describes oligonucleotide-tethered nucleotides, methods of making them, and methods of using them. The oligonucleotide-tethered nucleotides comprise, in some embodiments, a nucleotide linked to an oligonucleotide of from about 3 to about 100 nucleotides in length. These oligonucleotide-tethered nucleotides can be used to label a plurality of different types of nucleic acids in a plurality of different situations with a known oligonucleotide, which can serve as a barcode in some embodiments. The resulting oligonucleotide-labeled nucleic acids oligonucleotides can be used in a variety of nucleic acid sequencing methods.
• A readily synthesized cyclic pyrrolysine analogue for site-specific protein “click” labeling
  作者：Ziyang Hao、Yanqun Song、Shixian Lin、Maiyun Yang、Yujie Liang、Jing Wang、Peng R. Chen

  DOI：10.1039/c1cc00024a

  日期：——

  A concise route was developed for the facile synthesis of a cyclic pyrrolysine analogue bearing an azide handle. Directed evolution enabled the encoding of this non-natural amino acid in both prokaryotic and eukaryotic cells, which offers a highly efficient approach for the site-specific protein labeling using click chemistry.

  开发了一种简便的方法，可轻松合成带有叠氮手柄的环状吡咯赖氨酸类似物。定向进化能够在原核和真核细胞中对该非天然氨基酸进行编码，这为使用点击化学进行位点特异性蛋白质标记提供了一种高效的方法。