hex-5-enyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate | 152857-60-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: hex-5-enyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate
• CAS: 152857-60-8
• 化学式: C₁₄H₂₅NO₃
• 分子量: 255.357
• InChiKey: UQNMNFLWSMHCJE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-己烯-1-醇 、 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carbonyl chloride 在 sodium hydride 作用下， 以 四氢呋喃 、 mineral oil 为溶剂， 反应 0.5h， 以99%的产率得到hex-5-enyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate
  参考文献：
  名称：

  Determination of the Effect of Cation−π Interactions on the Stability of α-Oxy-Organolithium Compounds

  摘要：

  Sn-Li exchange equilibria have allowed the quantification of the stabilizing effect of cation-pi interactions in organolithium chemistry. Stabilization energy data on the effect of Li-pi complexation of an aromatic ring or a C=C double bond in organolithium compounds are presented. The amount of stabilization gained by complexation of the Li atom with a pi system in alpha-oxy-organolithium compounds is quite comparable to the one observed in systems containing Li-N or Li-O interactions.

  DOI：

  10.1021/jo801176d

文献信息

• US5223633A
  申请人：——

  公开号：US5223633A

  公开（公告）日：1993-06-29
• Determination of the Effect of Cation−π Interactions on the Stability of α-Oxy-Organolithium Compounds
  作者：Pablo Monje、M. Rita Paleo、Luis García-Río、F. Javier Sardina

  DOI：10.1021/jo801176d

  日期：2008.9.19

  Sn-Li exchange equilibria have allowed the quantification of the stabilizing effect of cation-pi interactions in organolithium chemistry. Stabilization energy data on the effect of Li-pi complexation of an aromatic ring or a C=C double bond in organolithium compounds are presented. The amount of stabilization gained by complexation of the Li atom with a pi system in alpha-oxy-organolithium compounds is quite comparable to the one observed in systems containing Li-N or Li-O interactions.