4-hydroxy-N-octadecylbutanamide | 24231-51-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-hydroxy-N-octadecylbutanamide
• 英文别名: 4-Hydroxy-N-octadecylbutyramide
• CAS: 24231-51-4
• 化学式: C₂₂H₄₅NO₂
• 分子量: 355.605
• InChiKey: RTUJWXNVIYXGRA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  25
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  十八胺 在 lithium aluminium tetrahydride 、 三乙胺 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 3.0h， 生成 4-hydroxy-N-octadecylbutanamide
  参考文献：
  名称：

  功能化脂质的合成及其在可调节的核苷和核酸疏水化中的应用

  摘要：

  制备了两个功能化的单侧链和双侧链脂质分子（方案1和2）。该化合物带有末端COOH，OH或卤素取代基。此外，双侧链脂质18带有内部炔烃官能团。后一种化合物通过碱催化的烷基化作用在N（3）处使胸苷疏水化。此外，完全保护的胸苷，32，是N（3）烷基化与所述双面链醇9施加光延反应条件。

  DOI：

  10.1002/hlca.201100410

文献信息

• REACTIVE, LIPOPHILIC NUCLEOSIDE BUILDING BLOCKS FOR THE SYNTHESIS OF HYDROPHOBIC NUCLEIC ACIDS
  申请人：Ionovation GmbH

  公开号：US20190175633A1

  公开（公告）日：2019-06-13

  The present invention relates to a method for the isolation and/or identification of known or unknown sequences of nucleic acids (target sequences) optionally marked with reporter groups by base specific hybridation with complementary sequences using nucleolipids. The nucleolipids are prepared by lipophilizing nucleosides of formula (Ia) wherein Q represents a group having a substituted tetrahydrofuran ring and Bas represents a group having one or more heterocyclic rings having one or more heterocyclic nitrogen atoms.

  本发明涉及一种方法，用于通过碱特异性杂交与互补序列使用核苷酸脂质来分离和/或识别带有报告基团的已知或未知核酸序列（目标序列）。所述核苷酸脂质是通过使式（Ia）的核苷的亲脂化制备的， 其中，Q代表具有取代四氢呋喃环的基团，Bas代表具有一个或多个含有一个或多个杂环氮原子的杂环环的基团。
• Reactive, lipophilic nucleoside building blocks for the synthesis of hydrophobic nucleic acids
  申请人：Ionovation GmbH

  公开号：EP2712869A1

  公开（公告）日：2014-04-02

  The present invention relates to a method for the isolation and/or identification of known or unknown sequences of nucleic acids (target sequences) optionally marked with reporter groups by base specific hybridation with, essentially, complementary sequences (in the following referred to as sample oligonucleotides, sample sequences or sample nucleic acids), which belong to a library of sequences. Further, the invention relates to nucleolipids used in the method of the invention and a process for the preparation of said nucleolipids.

  本发明涉及一种用于通过与基本上互补序列（以下简称为样品寡核苷酸、样品序列或样品核酸）的碱基特异性杂交来分离和/或鉴定已知或未知核酸序列（目标序列）的方法，该目标序列可以选择性地标记有报告基团，这些目标序列属于一个序列库。此外，本发明涉及用于所述方法的核脂质以及用于制备所述核脂质的方法。
• COSMETIC BASE INCLUDING AMIDE ALCOHOL, AND COSMETIC
  申请人：Kokyu Alcohol Kogyo Co., Ltd.

  公开号：US20190343745A1

  公开（公告）日：2019-11-14

  The purpose of the present invention is to provide a novel amide alcohol that can be used as a cosmetic base ingredient. An amide alcohol represented by formula (I).

  本发明的目的是提供一种可用作化妆品基础成分的新型酰胺醇。一种由式（I）所表示的酰胺醇。
• Carboxylic amides as fungicides to eumycotina in phanerogamia plant life
  申请人：GAF Corporation

  公开号：US04195096A1

  公开（公告）日：1980-03-25

  This invention relates to the control and/or eradication of Eumycotina type fungi in phanerogamia plants with one or more of the substituted carboxylic amides having the formula: ##STR1## wherein A is an organic radical of from 2 to 14 carbon atoms and is selected from the group consisting of hydroxyalkyl, hydroxyalkoxy, haloalkyl radicals and substituted alkylether radicals having the structure --R.sub.1 --O--R.sub.2 --, where R.sub.1 is alkylene of from 1 to 6 carbon atoms and R.sub.2 is alkyl of from 1 to 6 carbon atoms substituted with a hydroxy, carboxylate or halocarboxylate group; and wherein R is an acyclic alkyl radical, an alkenyl radical having one or more doubly bonded carbon atoms, a mono- or di- fluorinated benzyl radical or a mono- or di- chlorinated benzyl radical, said R radical containing from 4 to 20 carbon atoms. The invention also relates to a method of using a fungicidal amount of said carboxylic acid amide or carboxylic amide mixtures on phanerogamia plants for control or eradication of Eumycotina infection.

  本发明涉及使用一种或多种具有以下式子的取代羧酸酰胺对被Eumycotina类型真菌感染的被子植物进行控制和/或根除：##STR1## 其中A是有机基团，具有2到14个碳原子，并从羟基烷基，羟基烷氧基，卤代烷基基团和具有结构--R.sub.1--O--R.sub.2--的取代烷基醚基团中选择，其中R.sub.1是具有1到6个碳原子的烷基，R.sub.2是具有1到6个碳原子的烷基，被羟基，羧酸盐或卤代羧酸盐基团取代; R是无环烷基基团，具有一个或多个双键碳原子的烯基基团，一个或多个氟代苄基基团或一个或多个氯代苄基基团，该R基团含有4到20个碳原子。本发明还涉及使用所述羧酸酰胺或羧酸酰胺混合物的真菌杀菌量的方法，用于控制或根除Eumycotina感染的被子植物。
• Hydroxyalkyl amides as fungicides to eumycotina in phanerogamia plant
  申请人：GAF Corporation

  公开号：US04325973A1

  公开（公告）日：1982-04-20

  This invention relates to the control and/or eradication of Eumycotina type fungi is phanerogamia plants with one or more of the substituted carboxylic amides having the formula: ##STR1## wherein A is an organic radical of from 2 to 14 carbon atoms and is selected from the group consisting of hydroxyalkyl, hydroxyalkoxy, haloalkyl radicals and substituted alkylether radicals having the structure --R.sub.1 --O--R.sub.2 --, where R.sub.1 is alkylene of from 1 to 6 carbon atoms and R.sub.2 is alkyl of from 1 to 6 carbon atoms substituted with a hydroxy, carboxylate or halocarboxylate group; and wherein R is an acyclic alkyl radical, an alkenyl radical having one or more doubly bonded carbon atoms, a mono- or di- fluorinated benzyl radical or a mono- or di- chlorinated benzyl radical, said R radical containing from 4 to 20 carbon atoms. The invention also relates to a method of using a fungicidal amount of said carboxylic acid amide or carboxylic amide mixtures on phanerogamia plants for control or eradication of Eumycotina infection.

  本发明涉及使用一种或多种取代羧酸酰胺，其具有以下公式：##STR1##其中A是一个有机基团，其碳原子数为2到14个，选择自羟基烷基、羟基烷氧基、卤代烷基基团和取代烷基醚基团，其结构为--R.sub.1--O--R.sub.2--，其中R.sub.1是1到6个碳原子的烷基，R.sub.2是1到6个碳原子的烷基，带有羟基、羧酸盐或卤代羧酸盐基团；R是一个无环烷基、具有一个或多个双键碳原子的烯基基团、单氟或双氟苯甲基基团或单氯或双氯苯甲基基团，该R基团含有4到20个碳原子。本发明还涉及使用所述羧酸酰胺或羧酸酰胺混合物的杀菌剂量在有性植物上进行控制或根除真菌感染的方法。