4-(4-chlorophenoxymethyl)-1-(tetrahydrofuran-2-ylmethyl)-1H-[1,2,3]triazole | 1322786-88-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-(4-chlorophenoxymethyl)-1-(tetrahydrofuran-2-ylmethyl)-1H-[1,2,3]triazole
• 英文别名: 4-[(4-Chlorophenoxy)methyl]-1-(oxolan-2-ylmethyl)triazole
• CAS: 1322786-88-8
• 化学式: C₁₄H₁₆ClN₃O₂
• 分子量: 293.753
• InChiKey: NEMQSLPQJDFKFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  49.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  四氢糠醇 在 吡啶 、 sodium azide 作用下， 以 水 、 1,2-二氯乙烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 8.0h， 生成 4-(4-chlorophenoxymethyl)-1-(tetrahydrofuran-2-ylmethyl)-1H-[1,2,3]triazole
  参考文献：
  名称：

  Synthesis of (Tetrahydrofuranyl)methyl-1,2,3-triazoles Through Alkyne–Azide Cycloaddition Catalyzed by a Dithioic Acid Copper(I) Complex

  摘要：

  (Tetrahydrofuranyl)methyl-1,2,3-triazoles were synthesized from tetrahydrofurfuryl tosylate and several alkynes in the presence of catalytic amounts of a 3-hydroxy-3-phenyl-2-propenendithioate-bis(triphenylphosphine) copper(I) complex. The reaction process is carried in out under mild conditions, and bases or reducing agents were not used. The reaction afforded the 1,4-regioisomers in excellent yields.

  DOI：

  10.1080/00397911.2010.516052

文献信息

• Synthesis of (Tetrahydrofuranyl)methyl-1,2,3-triazoles Through Alkyne–Azide Cycloaddition Catalyzed by a Dithioic Acid Copper(I) Complex
  作者：Bayardo E. Velasco、Aydeé Fuentes、Carlos Gonzalez、David Corona、Iván García-Orozco、Erick Cuevas-Yañez

  DOI：10.1080/00397911.2010.516052

  日期：2011.10.15

  (Tetrahydrofuranyl)methyl-1,2,3-triazoles were synthesized from tetrahydrofurfuryl tosylate and several alkynes in the presence of catalytic amounts of a 3-hydroxy-3-phenyl-2-propenendithioate-bis(triphenylphosphine) copper(I) complex. The reaction process is carried in out under mild conditions, and bases or reducing agents were not used. The reaction afforded the 1,4-regioisomers in excellent yields.