8-(acetylthio)octyl bromide | 210686-25-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 硫代羧酸及其衍生物
• 英文名称: 8-(acetylthio)octyl bromide
• 英文别名: 8-bromo-1-octyl thioacetate；Ethanethioic acid, S-(8-bromooctyl) ester；S-(8-bromooctyl) ethanethioate
• CAS: 210686-25-2
• 化学式: C₁₀H₁₉BrOS
• 分子量: 267.23
• InChiKey: MFBDRINSWYDMDX-UHFFFAOYSA-N

物化性质

• 沸点：
  306.9±25.0 °C(Predicted)
• 密度：
  1.226±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  13
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  8-(acetylthio)octyl bromide 在 lithium chloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  Preparation of ω-tetrahydropyran-2-ylsulfanylalkylmagnesium chlorides: Useful reagents for the synthesis of 1-(ω-mercaptoalkyl)-1,2-dihydrobuckminsterfullerenes (C60)

  摘要：

  omega-Tetrahydropyran-2-ylsulfanylalkylmagnesium chlorides are prepared as Grignard reagents containing protected mercaptoalkyl chains, which are useful for the direct introduction of omega-mercaptoalkyl chains to electrophiles. In order to prove the usefulness of these reagents, they were reacted with buckminsterfullerene (C(60)) to give 1-(omega-mercaptoalkyl)-1,2-dihydrobuckminsterfullerenes after the deprotection of THP group with TFA. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)02142-x
• 作为产物：
  描述：

  1,8-二溴辛烷 、 硫代乙酸 在 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 生成 8-(acetylthio)octyl bromide
  参考文献：
  名称：

  Preparation of ω-tetrahydropyran-2-ylsulfanylalkylmagnesium chlorides: Useful reagents for the synthesis of 1-(ω-mercaptoalkyl)-1,2-dihydrobuckminsterfullerenes (C60)

  摘要：

  omega-Tetrahydropyran-2-ylsulfanylalkylmagnesium chlorides are prepared as Grignard reagents containing protected mercaptoalkyl chains, which are useful for the direct introduction of omega-mercaptoalkyl chains to electrophiles. In order to prove the usefulness of these reagents, they were reacted with buckminsterfullerene (C(60)) to give 1-(omega-mercaptoalkyl)-1,2-dihydrobuckminsterfullerenes after the deprotection of THP group with TFA. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)02142-x

文献信息

• Preparation of Donor-σ-Acceptor Molecules Using Arene−Ruthenium Chemistry
  作者：Anthony J. Pearson、Jiunn-Jye Hwang

  DOI：10.1021/jo000018s

  日期：2000.6.1

  (S(N)Ar) reactions. Selective substitution of chloride from cyclopentadienyl(1,4-dichlorobenzene)ruthenium by using piperazine derivatives as nucleophiles is addressed. This selectivity, in combination with further manipulation of the complexes, allows the preparation of unsymmetrically functionalized tetraalkyl-p-phenylenediamine (TAPD) units which are difficult to synthesize by traditional organic

  已通过钌活化的亲核芳香族取代（S（N）Ar）反应制备了具有硫代烷基侧链的几个供体-σ受体（D-sigma-A）分子。解决了通过使用哌嗪衍生物作为亲核试剂从环戊二烯基（1,4-二氯苯）钌中选择性取代氯的方法。这种选择性与配合物的进一步处理相结合，可以制备不对称官能化的四烷基对苯二胺（TAPD）单元，这些单元很难通过传统的有机S（N）Ar条件合成。描述了在紫外辐射下苯并菲对芳烃-RuCp体系的分解。
• NEPHROTROPIC DRUGS
  申请人：Drug Delivery System Institute, Ltd.

  公开号：EP0953357A1

  公开（公告）日：1999-11-03

  Disclosed are a drug having renal selectivity and a drug carrier for specifically transporting a drug supported thereon to a kidney. A segment structure specifically recognizable in the kidney is utilized. More specifically, since a segment structure represented by formula (I) is kidney-oriented, introduction of a drug into a molecule having the segment structure can provide a renal targeting drug. A compound, which has the segment structure and can support a drug thereon, can be utilized as a drug carrier which can specifically transport a drug supported thereon to the kidney.         A-U-V-     (I) wherein A represents glycosyl, such as glucosyl, mannosyl, or 2-deoxy-glucosyl; U represents O, S, or NH; and V represents an aromatic hydrocarbon or a straight-chain or branched C1-18 aliphatic hydrocarbon.

  本发明涉及一种具有肾脏选择性的药物和一种药物载体，用于将支持在其上的药物专门运输到肾脏。利用在肾脏中特别可识别的片段结构。更具体地说，由式（I）表示的片段结构是以肾脏为导向的，将药物引入具有该片段结构的分子中可以提供肾脏靶向药物。具有该片段结构并能支持药物的化合物可用作药物载体，可将支持在其上的药物专门运输到肾脏。其中，A代表糖基，如葡萄糖基、甘露糖基或2-脱氧葡萄糖基；U代表O、S或NH；V代表芳香族碳氢化合物或直链或支链C1-18脂肪族碳氢化合物。
• Assessment of the morphology of mixed SAMs on Au nanoparticles using a fluorescent probe
  作者：Renato Bonomi、Alessandro Cazzolaro、Leonard J. Prins

  DOI：10.1039/c0cc02260h

  日期：——

  The distribution of thiols in mixed SAMs can be determined in a straightforward manner from spectrophotometric titrations using a fluorescent probe. A plot of saturation concentration as a function of mole fraction provides information on the number of headgroups involved in binding.

  通过使用荧光探针进行分光光度滴定，可以直接确定混合 SAM 中硫醇的分布情况。饱和浓度与分子分数的函数关系图提供了参与结合的头基数的信息。
• Cleavable, water-soluble surfactants
  申请人：The Regents of the University of California

  公开号：US06600076B1

  公开（公告）日：2003-07-29

  The present invention provides a novel class of water-soluble cleavable surfactants and methods for utilizing these surfactants.

  本发明提供了一种新型水溶性可断裂表面活性剂的类别和利用这些表面活性剂的方法。
• Nanoparticle-Assisted NMR Detection of Organic Anions: From Chemosensing to Chromatography
  作者：Marie-Virginie Salvia、Federico Ramadori、Sara Springhetti、Marta Diez-Castellnou、Barbara Perrone、Federico Rastrelli、Fabrizio Mancin

  DOI：10.1021/ja511205e

  日期：2015.1.21

  Monolayer-protected nanoparticles provide a straightforward access to self-organized receptors that selectively bind different substrates in water. Molecules featuring different kinds of noncovalent interactions (namely, hydrophobic, ion pairing, and metal-ligand coordination) can be grafted on the nanoparticle surface to provide tailored binding sites for virtually any class of substrate. Not only the selectivity but also the strength of these interactions can be modulated. Such recognition ability can be exploited with new sensing protocols, based on NMR magnetization transfer and diffusion-ordered spectroscopy (DOSY), to detect and identify organic molecules in complex mixtures.