Ethyl 2-methyl-2-nonenoat | 6305-58-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Ethyl 2-methyl-2-nonenoat
• 英文别名: Ethyl-2-methyl-non-2-enoat；Ethyl 2-methylnon-2-enoate
• CAS: 6305-58-4
• 化学式: C₁₂H₂₂O₂
• 分子量: 198.305
• InChiKey: OJAZWYSGUPIGHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Ethyl 2-methyl-2-nonenoat 在 lead(IV) acetate 、 titanium(IV) isopropylate 、 4 A molecular sieve 、 sodium hydride 、 二异丁基氢化铝 作用下， 以 苯 为溶剂， 反应 23.33h， 生成 Methyl (4R)-3-methyl-4-<(phenylthio)acetoxy>-dec-2(E)-enoate
  参考文献：
  名称：

  Stereoselective Synthesis of Highly Substituted .gamma.-Lactones and Butenolides by Intramolecular Michael Addition of Enantiomerically Enriched .gamma.-[(Phenylthio)acyl]oxy .alpha.,.beta.-Unsaturated Esters

  摘要：

  The synthesis of polysubstituted gamma-lactones by the base-induced cyclization of enantiomerically enriched gamma-((phenylthio)acyl)oxy alpha,beta-unsaturated esters obtained from 2,3-epoxy alcohols is described. The procedure is highly stereoselective and compatible with a wide range of functionalities (ester, tetrahydropyranyl ether, silyl ether, etc.). Varying degrees of substitution, including quaternary centers, in the final gamma-lactone were synthesized with excellent stereoselectivity. Useful functional interconversions were successfully demonstrated, in particular those resulting in butenolides. By the use of AM1 it was concluded that the intramolecular Michael reaction can be described as a kinetically controlled reaction in which the relative stability of the transition states for all possible final configurations led to geometries in agreement with the experimental results.

  DOI：

  10.1021/jo00095a022
• 作为产物：
  描述：

  2-巯基丙酸乙酯 、 庚醛 生成 Ethyl 2-methyl-2-nonenoat
  参考文献：
  名称：

  使用二硫代碳酸酯的单阴离子、巯基乙酸乙酯和 2-巯基丙酸乙酯的二价阴离子从羰基化合物合成 α,β-不饱和羧酸酯的新方法

  摘要：

  发现 O-烷基 S-烷氧基羰基甲基二硫代碳酸酯和单硫代碳酸酯的锂烯醇化物是从羰基化合物合成 α,β-不饱和酯的有效试剂...

  DOI：

  10.1246/bcsj.52.3619

文献信息

• [EN] COMPOUNDS FOR OPTICALLY ACTIVE DEVICES<br/>[FR] COMPOSÉS POUR DISPOSITIFS OPTIQUEMENT ACTIFS
  申请人：MERCK PATENT GMBH

  公开号：WO2020212543A1

  公开（公告）日：2020-10-22

  The present invention relates to novel ophthalmic devices comprising polymerized compounds comprising a photoactive unit, said polymerized compounds, and special monomer compounds being particularly suitable for compositions and ophthalmic devices.

  本发明涉及包含光活性单元的聚合化合物的创新眼科设备，所述聚合化合物，以及特别适合用于组合物和眼科设备的特殊单体化合物。
• [EN] NUCLEIC ACID COMPLEX<br/>[FR] COMPLEXE D'ACIDE NUCLÉIQUE
  申请人：COMMW SCIENT IND RES ORG

  公开号：WO2013003887A1

  公开（公告）日：2013-01-10

  The present invention relates to a complex comprising a cationic block copolymer and a nucleic acid, the cationic block copolymer having at least a tri-block structure comprising a cationic block and two hydrophilic blocks, or a hydrophilic block and two cationic blocks.

  本发明涉及一种包含阳离子嵌段共聚物和核酸的复合物，其中所述阳离子嵌段共聚物至少具有三嵌段结构，包括一个阳离子嵌段和两个亲水性嵌段，或一个亲水性嵌段和两个阳离子嵌段。
• Polymer with upper critical solution temperature
  申请人：THE BOEING COMPANY

  公开号：US20200361859A1

  公开（公告）日：2020-11-19

  Aspects generally relate to a temperature responsive polymer, more specifically to a polymer exhibiting an upper critical solution temperature (UCST) in an aqueous solution. In one aspect, a monomer compound includes one or more amide or thioamide groups; one or more ureido or thioureido groups; and one or more ethylenically unsaturated groups. In one aspect, a polymer, such as a homopolymer or a copolymer, is produced by polymerization of the monomer compound. The copolymer is produced by polymerization of the monomer compound and a comonomer, such as a hydrophobic comonomer, a hydrophilic comonomer, a pH responsive comonomer, a light responsive comonomer, and combinations thereof. The polymer exhibits a UCST from about 1° C. to about 100° C. in an aqueous solution at 1 atm.

  方面通常涉及温度响应聚合物，更具体地是在水溶液中表现出上临界溶液温度（UCST）的聚合物。在一个方面，单体化合物包括一个或多个酰胺或硫酰胺基团；一个或多个脲基或硫脲基团；和一个或多个乙烯不饱和基团。在一个方面，通过单体化合物的聚合制备聚合物，如均聚物或共聚物。共聚物是通过单体化合物和共聚单体（如疏水性共聚单体、亲水性共聚单体、pH响应共聚单体、光响应共聚单体及其组合）的聚合制备的。在1个大气压下，聚合物在水溶液中表现出从约1°C到约100°C的UCST。
• [EN] AZACOUMARIN AND AZATHIOCOUMARIN DERIVATIVES FOR USE IN OPTICALLY ACTIVE DEVICES<br/>[FR] DÉRIVÉS D'AZACOUMARINES ET D'AZATHIOCOUMARINE DESTINÉS À ÊTRE UTILISÉS DANS DES DISPOSITIFS OPTIQUEMENT ACTIFS
  申请人：MERCK PATENT GMBH

  公开号：WO2021233800A1

  公开（公告）日：2021-11-25

  The present invention relates to novel ophthalmic devices comprising polymerized compounds comprising a photoactive chromophore, said polymerized compounds, and special monomer compounds being particularly suitable for compositions and ophthalmic devices. The present invention is also directed to a process of changing the optical properties of said ophthalmic device or a precursor article for manufacturing said ophthalmic device.

  本发明涉及包括聚合物化合物的新型眼科器件，所述聚合物化合物包括光活性色素，以及特殊单体化合物，特别适用于眼科器件的组合物和眼科器件。本发明还涉及一种改变所述眼科器件的光学性能或用于制造所述眼科器件的前体物品的方法。
• NOVEL COMPOUND HAVING alpha-CYANOACRYLATE STRUCTURE, DYE, AND COLORED PHOTOSENSITIVE COMPOSITION
  申请人：Maeda Yosuke

  公开号：US20140005292A1

  公开（公告）日：2014-01-02

  A compound represented by the following general formula (1). In the formula, A represents a benzene ring, a naphthalene ring and the like, wherein these rings may be substituted with a halogen atom and the like, R 1 represents a hydrogen atom and the like, R 2 represents a C 1-35 hydrocarbon group having or not having at least one group selected from an epoxy group, 4-vinylphenyl group and a (meth)acryloyloxy group, or a hydrogen atom, wherein at least one of R 2 with n occurrences is a C 3-35 hydrocarbon group having at least one group selected from an epoxy group, a 4-vinylphenyl group and a (meth)acryloyloxy group, n represents an integer of 1 to 6, and X represents a nitrogen atom, an oxygen atom, a sulfur atom, a phosphorus atom, or an n-valent organic group having 35 or less carbon atoms.

  以下为通式（1）所代表的化合物。其中，A代表苯环、萘环等，这些环可能被卤素等取代，R1代表氢原子等，R2代表具有或不具有环氧基团、4-乙烯基苯基团和（甲基）丙烯酰氧基团中至少一种基团的C1-35碳氢基团或氢原子，其中R2中至少有一个出现n次的基团是具有至少一种环氧基团、4-乙烯基苯基团和（甲基）丙烯酰氧基团中的一种的C3-35碳氢基团，n表示1到6的整数，X表示氮原子、氧原子、硫原子、磷原子或具有35个或更少碳原子的n价有机基团。