5-(氯甲基)-6-甲基-2,4(1H,3H)-嘧啶二酮 | 66947-91-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 5-(氯甲基)-6-甲基-2,4(1H,3H)-嘧啶二酮
• 中文别名: 5-(氯甲基)-6-甲基-嘧啶二酮
• 英文名称: 5-(chloromethyl)-6-methyluracil
• 英文别名: 5-Chlormethyl-6-methyluracil；5-chloromethyl-6-methyl-1H-pyrimidine-2,4-dione；5-Chlormethyl-6-methyl-1H-pyrimidin-2,4-dion；5-chloromethyl-6-methyluracil；5-(Chloromethyl)-6-methylpyrimidine-2,4(1H,3H)-dione；5-(chloromethyl)-6-methyl-1H-pyrimidine-2,4-dione
• CAS: 66947-91-9
• 化学式: C₆H₇ClN₂O₂
• mdl: MFCD08059795
• 分子量: 174.587
• InChiKey: UATTVYPRSYQMDN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-(氯甲基)-6-甲基-2,4(1H,3H)-嘧啶二酮 在 sodium hydride 、 N,N-二乙基苯胺 、 三氯氧磷 作用下， 以 甲醇 、 氯仿 、 N,N-二甲基甲酰胺 为溶剂， 反应 48.0h， 生成 N,N-diethyl-5-(ethylsulfanylmethyl)-2-methoxy-6-methylpyrimidin-4-amine
  参考文献：
  名称：

  5-Ethylthiomethyl- und 5-Ethylsulfonylmethylpyrimidine

  摘要：

  DOI：

  10.1007/bf00816533
• 作为产物：
  描述：

  5-羟基甲基-6-甲基尿嘧啶 以 溶剂黄146 为溶剂， 生成 5-(氯甲基)-6-甲基-2,4(1H,3H)-嘧啶二酮
  参考文献：
  名称：

  Cephalosporin derivatives

  摘要：

  一种化学式为I的头孢菌素衍生物：##STR1## 其中X为##STR2## 代表头孢菌素领域已知的C-7酰基之一，R3为氢或甲氧基，R4为氢，可选择地取代的烷基或烯丙基，R5是通过碳链连接的含有季铵氮原子的芳香杂环环系统。

  公开号：

  US05049558A1

文献信息

• Uracil derivatives and use thereof in photographic products and processes
  申请人：POLAROID CORPORATION

  公开号：EP0071282A2

  公开（公告）日：1983-02-09

  There are described novel compounds which are represented by the formula wherein R is -CH2-A- or -CH2- = A; A is sulfur or selenium; X represents the nonmetallic atoms necessary to form a nucleus which completes a five or six membered heterocyclic moiety; R, is H or lower alkyl; R2 is H or a hydrolyzable group; and R3 is H, alkyl or a hydrolyzable group. The compounds are useful in photographic applications and provide controlled release of a photographically useful material during processing of photographic elements with an aqueous alkaline processing composition.

  所述新型化合物由以下式子表示 其中 R 是-CH2-A-或-CH2- = A；A 是硫或硒；X 代表形成核所需的非金属原子，该核完成一个五或六成员杂环分子；R 是 H 或低级烷基；R2 是 H 或可水解基团；R3 是 H、烷基或可水解基团。这些化合物在摄影应用中非常有用，可在使用水性碱性冲洗组合物冲洗照片元件时，控制释放对摄影有用的材料。
• Interaction of Chloromethyl Ether with 4-Methyluracil.^1,2 II
  作者：Margaret M. Endicott、Treat B. Johnson

  DOI：10.1021/ja01853a010

  日期：1941.8
• Elimination reactions of .alpha.-substituted thymines derived from tautomeric heterocyclic thiols and selenols
  作者：James R. Bartels-Keith、J. Barry Mahoney、Anthony J. Puttick

  DOI：10.1021/jo00207a015

  日期：1985.4
• Berlin; Wasilewa, Zhurnal Obshchei Khimii, 1958, vol. 28, p. 1063,1064;engl.Ausg.S.1033
  作者：Berlin、Wasilewa

  DOI：——

  日期：——
• Gene Expression Profile of Long-Lived Snell Dwarf Mice
  作者：I. Dozmorov、A. Galecki、Y. Chang、R. Krzesicki、M. Vergara、R. A. Miller

  DOI：10.1093/gerona/57.3.b99

  日期：2002.3.1

  To gain further insight into the basis for the extended longevity and delayed aging of Snell dwarf (dw/dw) mice, we have measured levels of expression of 2352 genes in liver of mice at 6 months of age. We find 60 genes for the which the Student's t statistic meets the arbitrary criterion of p < .001, and among these 17 meet the Bonferroni-adjusted significance criterion at p < .05, which corresponds to a nominal value of p < .00002. Using the Bonferroni criterion. we find that dwarf mice show increases in liver mRNA for two mannose-binding lectins, two DNA binding protein,,, serum amyloid P component. corticosteroid-binding globulin. and insulin-like growth factor -binding protein 2, as well as decreases in a two phosphodiesterases. a pheromone-binding urinary protein, insulin-like growth factor-I (IGF-I). a calcium-binding protein calgranulin B, a deubiquitinating enzyme. a hydroxysteroid dehydrogenase, a DNA methyltransferase, a glycine transporter, ania placental lactogen. We also use this data set to compare the results of different suggested criteria for evaluating intergroup differences in gene expression. Of the 2352 genes examined, 524 (22%) showed a twofold difference between dwarf and normal mice. but most of these fail to meet the conventional significance criterion of p < .05, let alone criteria C that have been adjusted to compensate for multiple comparison artifacts. The list of genes that show reliable differences between dwarf and control animals provides new insights into the C range of changes induced by deficiencies in growth hormone, thyroid-stimulating hormone. and prolactin, and it will help to guide further studies of the pathways by which these hormone defic- ciencies contribute to delayed aging in these mutant mice.