2-acetyl-3-methyl-succinic acid-1-ethyl ester | 90833-10-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: 2-acetyl-3-methyl-succinic acid-1-ethyl ester
• 英文别名: 2-Acetyl-3-methyl-bernsteinsaeure-1-aethylester；3-Ethoxycarbonyl-2-methyl-4-oxopentanoic acid
• CAS: 90833-10-6
• 化学式: C₉H₁₄O₅
• 分子量: 202.207
• InChiKey: YBMRBMYRHQRNAP-UHFFFAOYSA-N

物化性质

• 熔点：
  66-67 °C
• 沸点：
  327.3±27.0 °C(Predicted)
• 密度：
  1.168±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  80.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-acetyl-3-methyl-succinic acid-1-ethyl ester 生成 2-乙基乙酰乙酸乙酯
  参考文献：
  名称：

  Willstaetter; Clarke, Chemische Berichte, 1914, vol. 47, p. 298

  摘要：

  DOI：
• 作为产物：
  描述：

  乙酰乙酸乙酯 、 2-溴丙酸 在 copper(I) bromide sodium ethanolate 、 三乙胺 作用下， 生成 2-acetyl-3-methyl-succinic acid-1-ethyl ester
  参考文献：
  名称：

  Synthesis of 3-Ethoxycarbonyl-3-buten-4-olides and 3-Ethoxycarbonyl-4-butanolides

  摘要：

  本文描述了从乙基2-氧羧酸酯和2-溴烷酸合成3-酰基-2-烷基-3-乙氧基碳酰基丙酸。这些酸通过分子内脱水环化，生成2,4-二烷基-3-乙氧基碳酰基-3-丁烯-4-内酯，或者与烯丙基锌试剂缩合，生成4-烯基-2,4-二烷基-3-乙氧基碳酰基-4-内酯。

  DOI：

  10.1055/s-1985-31423

文献信息

• Synthese de β-ethoxycarbonyl λ-lactones
  作者：F. Gaudemar-Bardone、M. Mladenova、R. Couffignal

  DOI：10.1016/s0040-4039(01)80096-4

  日期：1984.1
• GAUDEMAR-BARDONE, F.;MLADENOVA, M.;COUFFIGNAL, R., TETRAHEDRON LETT., 1984, 25, N 10, 1047-1048
  作者：GAUDEMAR-BARDONE, F.、MLADENOVA, M.、COUFFIGNAL, R.

  DOI：——

  日期：——
• GAUDEMAR-BARDONE, F.;MLADENOVA, M.;COUFFIGNAL, R., SYNTHESIS, BRD, 1985, N 11, 1043-1047
  作者：GAUDEMAR-BARDONE, F.、MLADENOVA, M.、COUFFIGNAL, R.

  DOI：——

  日期：——
• Stapedectomy Revision in Elderly Patients
  作者：William H. Lippy、Jennifer Wingate、John M. Burkey、Franklin M. Rizer、Arnold G. Schuring

  DOI：10.1097/00005537-200206000-00030

  日期：2002.6

  AbstractObjective the objective was to determine the effectiveness of stapedectomy revision in patients 65 years of age or older. Although stapedectomy revision has been discussed in the literature, as well as primary stapedectomy surgery for elderly patients, we could find no study dedicated to stapedectomy revision in elderly patients.Study Design Retrospective.Methods One hundred twenty patients 65 years of age or older who had a stapedectomy revision between 1980 and 2001 were included. A randomly selected group of 120 patients younger than 65 years of age who had stapedectomy revision were included for comparison. Audiometric results were compared for the two groups. Surgical findings for each group are also discussed.Results The mean pure‐tone average hearing improvement for each group was 17.6 dB. The success rate was 70.8% for the elderly group and 67.6% for the younger group. Surgical findings during revision in elderly patients were generally the same as those found for younger patients.Conclusion Advanced age should not be seen as a contraindication to stapedectomy revision.
• US4096177A
  申请人：——

  公开号：US4096177A

  公开（公告）日：1978-06-20