L-Octopin | 63358-46-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-Octopin
• 英文别名: N^α-((S)-1-carboxy-ethyl)-D-arginine；(-)-Octopin；N^α-((S)-1-Carboxy-aethyl)-D-arginin；(+)(2S:1'R)-2-(1-Carboxy-aethylamino)-5-guanidino-valeriansaeure；N^α-(D-1-Carboxy-aethyl)-L-arginin；(2R)-2-[[(1S)-1-carboxyethyl]amino]-5-(diaminomethylideneamino)pentanoic acid
• CAS: 63358-46-3
• 化学式: C₉H₁₈N₄O₄
• 分子量: 246.266
• InChiKey: IMXSCCDUAFEIOE-NTSWFWBYSA-N

物化性质

• 沸点：
  490.0±55.0 °C(Predicted)
• 密度：
  1.45±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.7
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  151
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  D-精氨酸 、 2-溴丙酸 在 水 作用下， 生成 N^α-((R)-1-carboxy-ethyl)-D-arginine 、 L-Octopin
  参考文献：
  名称：

  Studies on Diastereoisomeric α-Amino Acids and Corresponding α-Hydroxy Acids. VIII. Configuration of the Isomeric Octopines

  摘要：

  DOI：

  10.1021/ja01560a039

文献信息

• Chemosensory Receptor Ligand-Based Therapies
  申请人：Brown Martin R.

  公开号：US20130303466A1

  公开（公告）日：2013-11-14

  Provided herein are methods for treating conditions associated with a chemosensory receptor, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administering a composition comprising a chemosensory receptor ligand. Also provided herein are chemosensory receptor ligand compositions and methods for the preparation thereof for use in the methods of the present invention.
• [EN] CHEMOSENSORY RECEPTOR LIGAND-BASED THERAPIES<br/>[FR] THÉRAPIES À BASE DE LIGAND DE RÉCEPTEUR CHIMIOSENSIBLE
  申请人：ELCELYX THERAPEUTICS INC

  公开号：WO2012054527A2

  公开（公告）日：2012-04-26

  Provided herein are methods for treating conditions associated with a chemosensory receptor, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administering a composition comprising a chemosensory receptor ligand. Also provided herein are chemosensory receptor ligand compositions and methods for the preparation thereof for use in the methods of the present invention.
• Studies on Diastereoisomeric α-Amino Acids and Corresponding α-Hydroxy Acids. VIII. Configuration of the Isomeric Octopines
  作者：Nobuo Izumiya、Roy Wade、Milton Winitz、M. Clyde Otey、Sanford M. Birnbaum、Robert J. Koegel、Jesse P. Greenstein

  DOI：10.1021/ja01560a039

  日期：1957.2