9,10-dihydro-9,10-ethanoanthracene-11-carboxylic acid | 5434-63-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 9,10-dihydro-9,10-ethanoanthracene-11-carboxylic acid
• 英文别名: 9,10-dihydro-9,10-ethanoanthracene-12-carboxylic acid；Dihydro-9.10-ethano-9.10-anthracen-carboxylsaeure-11；11-Carboxy-9,10-dihydro-9,10-ethan-anthracen；9,10-Dihydro-9,10-aethano-anthracen-11-carbonsaeure；(+/-)-9.10-Dihydro-9.10-aethano-anthracen-carbonsaeure-(11)；tetracyclo[6.6.2.02,7.09,14]hexadeca-2,4,6,9,11,13-hexaene-15-carboxylic acid
• CAS: 5434-63-9
• 化学式: C₁₇H₁₄O₂
• 分子量: 250.297
• InChiKey: LZKBBIGRPXLMRB-UHFFFAOYSA-N

物化性质

• 熔点：
  189-191 °C(Solv: benzene (71-43-2))
• 沸点：
  443.9±45.0 °C(Predicted)
• 密度：
  1.284±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2916399090

反应信息

• 作为反应物：
  描述：

  9,10-dihydro-9,10-ethanoanthracene-11-carboxylic acid 在 palladium on barium sulfate 2,6-二甲基吡啶 、 氯化亚砜 、 N,N-二甲基甲酰胺 、 氘 作用下， 以 二氯甲烷 、 苯 为溶剂， 生成 9,10-Dihydro-9,10-ethano-anthracen-11-carboxaldehyd-13-d1
  参考文献：
  名称：

  Irradiation of .alpha.,.beta.-unsaturated ketones. Search for intermediate oxabicyclobutanes

  摘要：

  DOI：

  10.1021/ja00759a027
• 作为产物：
  描述：

  9,10-dihydro-9,10-ethanoanthracene-11-carbaldehyde 在 air 作用下， 生成 9,10-dihydro-9,10-ethanoanthracene-11-carboxylic acid
  参考文献：
  名称：

  X-ray and computational investigations of ethanoanthracenes: 9,10-dihydro-9,10-ethanoanthracene-12-carboxylic acid and 9,10-dihydro-9,10-ethanoanthracen-9-yl)-N-methylethanamine

  摘要：

  DOI：

  10.1080/15421406.2021.2008173

文献信息

• RESIST COMPOSITION, METHOD OF FORMING RESIST PATTERN, AND COMPOUND
  申请人：TOKYO OHKA KOGYO CO., LTD.

  公开号：US20200174365A1

  公开（公告）日：2020-06-04

  A resist composition containing a base material component of which solubility in a developing solution is changed due to an action of an acid and a compound represented by Formula (bd1); in the formula, R bd1 to R bd3 each independently represent an aryl group which may have a substituent, provided that one or more of R bd1 to R bd3 are aryl groups having a fluorinated alkyl group which may have a substituent, and at least one of the fluorinated alkyl groups which may have a substituent in these aryl groups is bonded to a carbon atom adjacent to a carbon atom that is bonded to a sulfur atom in the formula, and a total number of the fluorinated alkyl groups which may have a substituent is 2 or more; X − represents a counter anion.

  一种抗蚀组合物，含有基础材料组分，其在显影溶液中的溶解性由酸的作用和由化合物代表的公式（bd1）改变；在公式中，Rbd1到Rbd3各自独立地代表可能具有取代基的芳基，前提是Rbd1到Rbd3中的一个或多个是可能具有取代基的芳基，而这些芳基中至少有一个可能具有取代基的氟代烷基与公式中与硫原子相结合的碳原子相邻的碳原子结合，可能具有取代基的氟代烷基的总数为2或更多；X−代表一个对离子。
• Use of bridged tricyclic amine derivatives as anti-ischemic agents
  申请人：G. D. Searle & Co.

  公开号：US05055468A1

  公开（公告）日：1991-10-08

  Certain bridged tricyclic amine compounds are described as being therapeutically effective in treatments of CNS disorders resulting from neurotoxic damage or neurodegenerative diseases, particularly those CNS disorders resulting from ischemic events. Compounds of particular interest for use as neuroprotective agents are those of the formula ##STR1## wherein each of R.sup.1 and R.sup.2 is independently selected from hydrido, loweralkyl, benzyl and phenyl; wherein each of R.sup.1 through R.sup.7 is independently selected from hydrido, loweralkyl, hydroxy, benzyl, phenyl, loweralkoxy, phenoxy, benzyloxy, halo and haloloweralkyl; wherein R.sup.18 may be selected from hydrido, loweralkyl, cycloalkyl of five or six carbon atoms, cycloalkylalkyl of six or seven carbon atoms, phenyl, hydroxyloweralkyl, and heteroaryl selected from saturated or fully unsaturated heterocyclic rings containing five to seven ring members of which one or two ring members are nitrogen atom; wherein each X is independently one or more groups selected from hydrido, hydroxy, loweralkyl, benzyl, phenyl, loweralkoxy, phenoxy, haloloweralkyl, halo, and lower-alkanoyl; and wherein each of R.sup.23 through R.sup.30 is independently selected from hydrido, lower alkyl, benzyl, phenyl and halo; wherein R.sup.18 together with one of R.sup.23, R.sup.24, R.sup.29 or R.sup.30 may form a fused heterocyclic ring containing five or six ring members; or a pharmaceutically-acceptable salt thereof.

  描述了某些桥接的三环胺化合物在治疗由神经毒性损伤或神经退行性疾病引起的中枢神经系统疾病方面具有治疗效果，特别是那些由缺血事件引起的中枢神经系统疾病。作为神经保护剂使用的特别感兴趣的化合物为具有以下结构的化合物：其中R.sup.1和R.sup.2中的每一个独立选择自氢化物、较低烷基、苄基和苯基；其中R.sup.1到R.sup.7中的每一个独立选择自氢化物、较低烷基、羟基、苄基、苯基、较低氧烷氧基、苯氧基、苄氧基、卤素和卤代较低烷基；其中R.sup.18可以选择自氢化物、较低烷基、五或六个碳原子的环烷基、六或七个碳原子的环烷基烷基、苯基、羟基较低烷基和由饱和或完全不饱和的含有五到七个环成员的杂环环选择的杂环芳基，其中一个或两个环成员是氮原子；其中每个X独立地选择自氢化物、羟基、较低烷基、苄基、苯基、较低氧烷氧基、苯氧基、卤代较低烷基、卤素和较低烷酰基的一个或多个基团；以及R.sup.23到R.sup.30中的每一个独立选择自氢化物、较低烷基、苄基、苯基和卤素；其中R.sup.18与R.sup.23、R.sup.24、R.sup.29或R.sup.30中的一个可以形成含有五个或六个环成员的融合杂环环；或其药用盐。
• RESIST COMPOSITION, METHOD OF FORMING RESIST PATTERN, COMPOUND, AND ACID GENERATOR
  申请人：TOKYO OHKA KOGYO CO., LTD.

  公开号：US20190361345A1

  公开（公告）日：2019-11-28

  A resist composition containing a compound represented by the general formula (bd1-1), (bd1-2) or (bd1-3); in the formula, Rx 1 to Rx 4 represent a hydrocarbon group or a hydrogen atom or may be mutually bonded to form a ring structure; Ry 1 to Ry 2 represent a hydrocarbon group or a hydrogen atom or may be mutually bonded to form a ring structure, Rz 1 to Rz 4 represent a hydrocarbon group or a hydrogen atom or may be mutually bonded to form a ring structure. At least one of Rx 1 to Rx 4 , Ry 1 to Ry 2 and Rz 1 to Rz 4 has an anion group, M 1 m+ represents a sulfonium cation having a sulfonyl group, R 001 to R 003 each independently represent a monovalent organic group; provided that at least one of R 001 to R 003 is an organic group having an acid dissociable group; and M 3 m+ represents an m-valent organic cation having an electron-withdrawing group.

  一种包含由通式（bd1-1）、（bd1-2）或（bd1-3）表示的化合物的抗蚀组合物；在该式中，Rx1到Rx4代表一个烃基或氢原子，或者它们可以相互连接形成环状结构；Ry1到Ry2代表一个烃基或氢原子，或者它们可以相互连接形成环状结构；Rz1到Rz4代表一个烃基或氢原子，或者它们可以相互连接形成环状结构。Rx1到Rx4、Ry1到Ry2和Rz1到Rz4中的至少一个具有一个阴离子基团，M1m+表示具有磺酰基的亚砜阳离子，R001到R003分别独立表示一价有机基团；但至少R001到R003中的一个是具有酸解离基团的有机基团；M3m+表示具有吸电子基团的m价有机阳离子。
• Decarboxyilative photooxygenation of carboxylic acids by tile use of acridine
  作者：Keiji Okada、Katsura Okubo、Masaji Oda

  DOI：10.1016/s0040-4039(00)77679-9

  日期：1992.1

  A new method of decarboxylative photooxygenation of free carboxylic acids is developed by the use of acridine as a light absorber, leading to alcohols after reductive treatment of the photolysate.

  通过使用of啶作为光吸收剂，开发了一种对游离羧酸进行脱羧光氧合的新方法，该光还原剂经过还原处理后生成醇。
• Synthesis of Precursors for the Pyrolytic Formation of Pentatetraenones
  作者：Phillip Arena、Roger F. C. Brown、Frank W. Eastwood、Don McNaughton

  DOI：10.1071/ch98174

  日期：——

  3-(9′,10′-Dihydro-9′,10′-ethanoanthracen-11′-ylidene)prop-2-enoyl chloride and its [12′,12′- 2 H2] and [1- 13 C] isotopomers have been prepared and pyrolysed. Argon matrix infrared spectroscopy showed ν2 bands at 2207 . 7, 2207 . 0, and 2168 . 5 cm−1 respectively for the three pentatetraenone isotopomers. The pyrolysate of the 12′-methyl substituted precursor showed a band at 2205 cm−1 which was tentatively assigned to methylpentatetraenone. The 12′-ethenyl substituted precursor gave a pyrolysate showing ketene bands but also yielded 9,10-dihydro-9,10[1′,2′]-benzenoanthracene.

  3-(9′,10′-二氢-9′,10′-乙桥蒽-11′-亚基)丙-2-烯酰 氯化物及其[12′,12′- 2 H2］ 及其[12′,12′- 2 H2]和[1- 13 C]同位素的制备和热解。 并进行了热解。氩基红外光谱显示 ν2 波段在 2207 .7, 2207 .0 和 2168 .5 cm-1 2207 . 0 和 2168 .12′-methyl 取代的前体的热裂解产物在 2205 cm-1 处显示出一条带。 初步归属于甲基五四烯酮。12′-ethenyl 取代的前体产生的热解产物显示出烯酮带，但也产生了 9,10-dihydro-9,10[1′,2′]-benzenoanthracene.