2-(2-aminoethyl)-5-nitropyridine | 503540-39-4

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 英文名称: 2-(2-aminoethyl)-5-nitropyridine
• 英文别名: 2-(5-Nitropyridin-2-YL)ethanamine
• CAS: 503540-39-4
• 化学式: C₇H₉N₃O₂
• mdl: MFCD10697665
• 分子量: 167.167
• InChiKey: TWNASODNSLSALA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  84.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  溴乙酸 、 苄胺 、 2-(2-aminoethyl)-5-nitropyridine 生成 2-Benzylamino-N-{[benzyl-({[(benzyl-carbamoylmethyl-carbamoyl)-methyl]-[2-(5-nitro-pyridin-2-yl)-ethyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-N-[2-(5-nitro-pyridin-2-yl)-ethyl]-acetamide
  参考文献：
  名称：

  通过固相亚单体合成将未保护的杂环侧链掺入拟肽低聚物中

  摘要：

  Peptoids（N-取代甘氨酸）是一类重要的仿生低聚物，近年来在组合药物发现、基因治疗、药物递送和生物聚合物折叠等领域产生了重大影响。通过固相亚单体方法可以很容易地从伯胺组装序列特异性拟肽寡聚物。然而，大多数在侧链中含有杂环氮的胺不能有效地结合。我们在此介绍了对亚单体方法的直接修订，该方法允许将未受保护的咪唑、吡啶、吡嗪、吲哚和喹啉有效结合到长度为 15 个单体的低聚物中。这种改进的方法在单体添加循环的酰化步骤中使用氯乙酸代替溴乙酸，

  DOI：

  10.1021/ja0352101

文献信息

• Polymers with structure-defined functions
  申请人：Greener Bryan

  公开号：US20050032929A1

  公开（公告）日：2005-02-10

  An alternating copolymer comprising a backbone of residues of a maleic anhydride derivative and those of a compound containing vinylic unsaturation, which also comprises residues of an active compound containing a nucleophilic group, bound to the backbone by a residue of the nucleophilic group, including such copolymer comprising residues of an active compound containing alcohol, thiol or amine group. The chemical and biological propertieis of actives, such as protease inhibitors, neurotransmitter drugs, and other small molecule active drugs, are enhanced, and new applications enabled. Also, artefacts, including a solid medical implant device, dressing or scaffold or a fluid adhesive or medicinal composition comprising such a polymer, and a method of use of such polymer, including a method for the treatment or prophylaxis of wounds

  一种交替共聚物，其骨架由马来酸酐衍生物残基和含有乙烯基不饱和度的化合物残基组成，其中还包括含有亲核基的活性化合物残基，通过亲核基残基与骨架结合，包括含有醇、硫醇或胺基的活性化合物残基的此类共聚物。活性物质（如蛋白酶抑制剂、神经递质药物和其他小分子活性药物）的化学和生物特性得到了增强，并实现了新的应用。此外，还包括固体医疗植入装置、敷料或支架，或包含此类聚合物的流体粘合剂或药物组合物，以及此类聚合物的使用方法，包括治疗或预防伤口的方法。
• OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF
  申请人：TREGA BIOSCIENCES, INC.

  公开号：EP1126833A2

  公开（公告）日：2001-08-29
• EP1126833A4
  申请人：——

  公开号：EP1126833A4

  公开（公告）日：2004-09-08
• POLYMERS WITH STRUCTURE-DEFINED FUNCTIONS
  申请人：Smith & Nephew PLC

  公开号：EP1436334A1

  公开（公告）日：2004-07-14
• Polymers With Structure-Defined Functions
  申请人：GREENER Bryan

  公开号：US20110300096A1

  公开（公告）日：2011-12-08

  An alternating copolymer comprising a backbone of residues of a maleic anhydride derivative and those of a compound containing vinylic unsaturation, which also comprises residues of an active compound containing a nucleophilic group, bound to the backbone by a residue of the nucleophilic group, including such a copolymer comprising residues of an active compound containing an alcohol, thiol or amine group. The chemical and biological properties of actives, such as protease inhibitors, neurotransmitter drugs, and other small molecule active drugs, are enhanced, and new applications enabled. Also, artefacts, including a solid medical implant device, dressing or scaffold or a fluid adhesive or medicinal composition comprising such a polymer, and a method of use of such a polymer, including a method for the treatment or prophylaxis of wounds.