7-OMe-DPAT | 78950-77-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 7-OMe-DPAT
• 英文别名: N,N-dipropyl-7-methoxy-1,2,3,4-tetrahydro-2-naphthylamine；2-Dipropylamino-7-methoxy-1,2,3,4-tetrahydronaphthalene；7-methoxy-N,N-dipropyl-1,2,3,4-tetrahydronaphthalen-2-amine
• CAS: 78950-77-3
• 化学式: C₁₇H₂₇NO
• 分子量: 261.407
• InChiKey: OKVMMISWCZKJGO-UHFFFAOYSA-N

物化性质

• 沸点：
  372.1±42.0 °C(Predicted)
• 密度：
  0.98±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  7-OMe-DPAT 在 吡啶 、 盐酸 、 盐酸羟胺 、 氨 、 氢溴酸 、 sodium 、 溶剂黄146 、 sodium sulfate 、 异丙醇 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成 N-<7-(dipropylamino)-5,6,7,8-tetrahydro-2-naphthalenyl>-2-(hydroxyimino)acetamide
  参考文献：
  名称：

  Drug design via pharmacophore identification. Dopaminergic activity of 3H-benz[e]indol-8-amines and their mode of interaction with the dopamine receptor

  摘要：

  The design and synthesis of a series of 3H-benz[e]indol-8-amines are described. Two of the compounds are potent, orally active dopaminergic agents as established by their ability to induce contralateral turning in rats with unilateral 6-hydroxydopamine-induced lesions of the nigrostriatal pathway, to induce ambulation in rats rendered akinetic by bilateral injections of 6-hydroxydopamine into the anterolateral hypothalamus, and to antagonize reserpine-induced catalepsy in mice. The dopamine agonist activity of the 3H-benz[e]indol-8-amines establishes that a pyrrolo ring and a phenolic hydroxyl group can interact similarly with the dopamine receptor and provides evidence for the existence of a hydrogen-bond acceptor nucleus on the dopamine receptor macromolecule that is involved in the behavioral manifestations of dopamine agonists.

  DOI：

  10.1021/jm00155a011
• 作为产物：
  描述：

  7-甲氧基-2-萘满酮 在 platinum(IV) oxide 、 氢气 、 对甲苯磺酸 作用下， 以 乙醇 、 苯 为溶剂， 25.0 ℃ 、202.65 kPa 条件下， 反应 50.5h， 生成 7-OMe-DPAT
  参考文献：
  名称：

  Drug design via pharmacophore identification. Dopaminergic activity of 3H-benz[e]indol-8-amines and their mode of interaction with the dopamine receptor

  摘要：

  The design and synthesis of a series of 3H-benz[e]indol-8-amines are described. Two of the compounds are potent, orally active dopaminergic agents as established by their ability to induce contralateral turning in rats with unilateral 6-hydroxydopamine-induced lesions of the nigrostriatal pathway, to induce ambulation in rats rendered akinetic by bilateral injections of 6-hydroxydopamine into the anterolateral hypothalamus, and to antagonize reserpine-induced catalepsy in mice. The dopamine agonist activity of the 3H-benz[e]indol-8-amines establishes that a pyrrolo ring and a phenolic hydroxyl group can interact similarly with the dopamine receptor and provides evidence for the existence of a hydrogen-bond acceptor nucleus on the dopamine receptor macromolecule that is involved in the behavioral manifestations of dopamine agonists.

  DOI：

  10.1021/jm00155a011

文献信息

• 6,7,8,9-Tetrahydro-3H-benz[E]indol-8-amine derivatives
  申请人：Ayerst, McKenna & Harrison, Ltd.

  公开号：US04370341A1

  公开（公告）日：1983-01-25

  Herein is disclosed compounds of the formula ##STR1## in which R.sup.1,R.sup.2,R.sup.3,R.sup.4 and R.sup.5 each is hydrogen or lower alkyl, therapeutically acceptable acid addition salts thereof, processes for their preparation, methods of using the compounds and pharmaceutical compositions. The compounds exhibit dopamine-receptor stimulating activity in a mammal and are useful for treating hyperprolactinemia, galactorrhea, amenorrhea, impotence, Parkinsonism, diabetes, acromegaly, hypertension and other central nervous system disorders.

  这里披露了以下式的化合物##STR1##，其中R.sup.1，R.sup.2，R.sup.3，R.sup.4和R.sup.5分别是氢或较低的烷基，其治疗上可接受的酸盐，它们的制备方法，使用这些化合物的方法以及药物组合物。这些化合物在哺乳动物中表现出多巴胺受体刺激活性，并可用于治疗高催乳素血症、乳汁分泌、闭经、阳痿、帕金森病、糖尿病、肢端肥大症、高血压和其他中枢神经系统疾病。
• 1,2,3,4-Tetrahydronaphthalene derivatives
  申请人：Synthelabo

  公开号：US04442126A1

  公开（公告）日：1984-04-10

  New compounds of the formula: ##STR1## wherein R.sub.1 represents a hydrogen atom or an alkanoyl group containing from 1 to 4 carbon atoms, R.sub.2 and R.sub.3 each represent a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group, and R.sub.4 represents a hydroxy or methoxy group in the 6-position or 7-position, have been found to be useful in therapy, and more particularly in the treatment of cardiovascular diseases and Parkinson's disease.

  新的化合物公式如下：##STR1## 其中R.sub.1代表氢原子或含有1至4个碳原子的烷酰基，R.sub.2和R.sub.3分别代表氢原子或C.sub.1-C.sub.4烷基，R.sub.4代表6位或7位的羟基或甲氧基。这些化合物已被发现在治疗心血管疾病和帕金森病方面非常有效。
• ASSELIN, A. A.;HUMBER, L. G.
  作者：ASSELIN, A. A.、HUMBER, L. G.

  DOI：——

  日期：——
• 6,7,8,9-Tetrahydro-3H-benz(e)indolamine derivatives, processes for their preparation and intermediates used therein, and pharmaceutical compositions containing the indolamine derivatives
  申请人：AYERST, MCKENNA AND HARRISON INC.

  公开号：EP0055043B1

  公开（公告）日：1985-01-23
• US4370341A
  申请人：——

  公开号：US4370341A

  公开（公告）日：1983-01-25