1,1'-(1,3-phenylenebis(oxy))bis(propan-2-one) | 118184-73-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1,1'-(1,3-phenylenebis(oxy))bis(propan-2-one)
• 英文别名: 1,3-bis-(acetonyloxy)benzene；2-Propanone, 1,1a(2)-[1,3-phenylenebis(oxy)]bis-；1-[3-(2-oxopropoxy)phenoxy]propan-2-one
• CAS: 118184-73-9
• 化学式: C₁₂H₁₄O₄
• 分子量: 222.241
• InChiKey: FNFZLDNZUYIJEM-UHFFFAOYSA-N

物化性质

• 熔点：
  57-58 °C(Solv: ligroine (8032-32-4))
• 沸点：
  352.2±22.0 °C(Predicted)
• 密度：
  1.124±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,1'-(1,3-phenylenebis(oxy))bis(propan-2-one) 、 3-氯-1,2-丙二醇 在 对甲苯磺酸 作用下， 以 甲苯 为溶剂， 以26%的产率得到1,3-bis-[(2-methyl-4-chloromethyl-1,3-dioxolane-2-yl) methylene oxy]benzene
  参考文献：
  名称：

  4-Methylene-1,3-dioxolanes as cross-linking agents

  摘要：

  公开号：

  EP1182201B1
• 作为产物：
  描述：

  溴丙酮 、 间苯二酚 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 24.33h， 以52%的产率得到1,1'-(1,3-phenylenebis(oxy))bis(propan-2-one)
  参考文献：
  名称：

  Calix[4]pyrroles with Shortest Possible Strap: Exclusively Selective toward Fluoride Ion

  摘要：

  Four new calix[4]pyrroles with the shortest possible strap so far through ortho-linking of the aromatic unit have been synthesized, including a naphthalene-derived fluorescent receptor. They show exclusive selectivity toward the fluoride ion as confirmed by H-1 NMR, isothermal titration calorimetry, and fluorescence spectroscopic study. Anion affinity could also be modulated further via functionalization at the strap. Computational analysis displays calix[4]pyrroles binding to fluoride ion in a very unusual 1,3-alternate conformation where the anion resides on the opposite side of the strap.

  DOI：

  10.1021/acs.orglett.5b01866

文献信息

• [EN] MACROMOLECULES OF DENDRIMER-PLATINUM CONJUGATES<br/>[FR] MACROMOLÉCULES DE CONJUGUÉS DENDRIMÈRE-PLATINE
  申请人：STARPHARMA PTY LTD

  公开号：WO2015035446A1

  公开（公告）日：2015-03-19

  The present invention relates to a macromolecule comprising a dendrimer having surface amino groups to which at least one platinum-containing moiety is attached. In particular embodiments, the macromolecule has a plurality of platinum-containing moieties attached to the surface amino groups. In another particular embodiment, the macromolecule comprises a dendrimer having surface amino groups to which at least two different moieties are attached, a first moiety being a platinum-containing moiety and the second moiety being a pharmacokinetic modifying agent or targeting agent. Pharmaceutical compositions comprising the macromolecules and uses of the macromolecules for treating or suppressing the growth of a cancer is also described.

  本发明涉及一种包括具有表面氨基团的树枝状分子的大分子，其中至少连接有一个含铂基团。在特定实施方式中，该大分子具有连接到表面氨基团的多个含铂基团。在另一特定实施方式中，该大分子包括具有表面氨基团的树枝状分子，其中至少连接有两种不同的基团，第一种基团是含铂基团，第二种基团是药代动力学改性剂或靶向剂。还描述了包括这些大分子的药物组合物以及这些大分子用于治疗或抑制癌症生长的用途。
• MACROMOLECULES OF DENDRIMER-PLATINUM CONJUGATES
  申请人：STARPHARMA PTY LTD.

  公开号：US20160220689A1

  公开（公告）日：2016-08-04

  A macromolecule comprising a dendrimer having surface amino groups to which at least one platinum-containing moiety is attached is provided. The macromolecule may have a plurality of platinum-containing moieties attached to the surface amino groups. Alternatively, the macromolecule may comprise a dendrimer having surface amino groups to which at least two different moieties are attached, a first moiety being a platinum-containing moiety and the second moiety being a pharmacokinetic modifying agent or targeting agent. Pharmaceutical compositions comprising the macromolecules and uses of the macromolecules for treating or suppressing the growth of a cancer is also described.

  本发明提供了一种大分子，包括具有表面氨基团的树状分子，至少一个含铂基团附着于其上。该大分子可以具有多个附着在表面氨基团上的含铂基团。或者，该大分子可以包括具有表面氨基团的树状分子，至少附着有两种不同的基团，第一种基团是含铂基团，第二种基团是药物动力学修饰剂或靶向剂。还描述了包括该大分子的制药组合物以及使用该大分子治疗或抑制癌症生长的用途。
• Macromolecules
  申请人：STARPHARMA PTY LTD

  公开号：US10265409B2

  公开（公告）日：2019-04-23

  A macromolecule includes i) a dendrimer with a core and at least one generation of lysine residue building units, the outermost generation of building units having surface amino groups, ii) a first terminal group covalently attached to a first surface amino group of a building unit, which includes a residue of docetaxel (DTX), and iii) a second terminal group covalently attached to a second surface amino group of a building unit, which includes a pharmacokinetic modifying agent. The pharmacokinetic modifying agent can be a polyethylene glycol (PEG). The first terminal group can be covalently attached to the surface amino group of the dendrimer through a diacid linker. The diacid linker can include a 2,2′-thiodiacetic acid residue. The diacid linker can form an ester bond with a hydroxyl group of the DTX and an amide bond with the surface amino group. A pharmaceutically acceptable salt of the macromolecule can be prepared.

  一种大分子包括 i) 树枝状聚合物，具有核心和至少一代赖氨酸残基构建单元，最外层的构建单元具有表面氨基；ii) 与构建单元的第一表面氨基共价连接的第一末端基团，其中包括多西他赛（DTX）残基；iii) 与构建单元的第二表面氨基共价连接的第二末端基团，其中包括药代动力学修饰剂。药代动力学修饰剂可以是聚乙二醇（PEG）。第一末端基团可通过二酸连接剂共价连接到树枝状聚合物的表面氨基上。二酸连接体可包括 2,2′-硫代乙酸残基。二酸连接体可与 DTX 的羟基形成酯键，与表面氨基形成酰胺键。可以制备大分子的药学上可接受的盐。
• SADYKOV, T.;ERZHANOV, K. B.;BASYMBEKOV, M. B.;PRALIEV, S. D., IZV. AN KAZSSR. CEP. XIM.,(1988) N 1, 63-67
  作者：SADYKOV, T.、ERZHANOV, K. B.、BASYMBEKOV, M. B.、PRALIEV, S. D.

  DOI：——

  日期：——
• MACROMOLECULES
  申请人：Owen David

  公开号：US20140171375A1

  公开（公告）日：2014-06-19

  The present invention relates to a macromolecule comprising a dendrimer having surface amino groups to which at least two different terminal groups are attached including a pharmaceutically active agent and a pharmacokinetic modifying agent, the pharmaceutically active agent comprising a hydroxyl group and being attached to the surface amino group of the dendrimer through a diacid linker. Pharmaceutical compositions comprising the macromolecules and methods of treatment using the macromolecules are also described.