dimethyl 2-(3-chlorophenyl)-1-tosyl-5-(trifluoromethyl)-1H-pyrrole-3,4-dicarboxylate | 1619266-79-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: dimethyl 2-(3-chlorophenyl)-1-tosyl-5-(trifluoromethyl)-1H-pyrrole-3,4-dicarboxylate
• 英文别名: Dimethyl 2-(3-chlorophenyl)-1-(4-methylphenyl)sulfonyl-5-(trifluoromethyl)pyrrole-3,4-dicarboxylate；dimethyl 2-(3-chlorophenyl)-1-(4-methylphenyl)sulfonyl-5-(trifluoromethyl)pyrrole-3,4-dicarboxylate
• CAS: 1619266-79-3
• 化学式: C₂₂H₁₇ClF₃NO₆S
• 分子量: 515.894
• InChiKey: NWDXPNZELLOTGF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  100
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  三氟乙酸酐 、 (E)-2-[(3-chlorophenyl)(toluene-4-sulfonylimino)methyl]but-2-enedioic acid dimethyl ester 在 三苯基膦 作用下， 以 二氯甲烷 为溶剂， 以95%的产率得到dimethyl 2-(3-chlorophenyl)-1-tosyl-5-(trifluoromethyl)-1H-pyrrole-3,4-dicarboxylate
  参考文献：
  名称：

  Phosphine-mediated synthesis of trifluoromethyl substituted pyrroles using TFAA as the CF3 source

  摘要：

  A phosphine-mediated synthesis of trifluoromethyl substituted pyrrole derivatives was achieved. The method described here is very fast, operationally simple, and easily amenable to scale-up, and commercially available trifluoroacetic anhydride (TFAA) is used as the only trifluoromethyl source. A wide range of products were obtained with good yields under mild condition using this method. 0(C)2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.05.127

文献信息

• Phosphine-mediated synthesis of trifluoromethyl substituted pyrroles using TFAA as the CF3 source
  作者：Dan-Dan Tang、Yao Wang、Jun-Ru Wang、Peng-Fei Xu

  DOI：10.1016/j.tetlet.2014.05.127

  日期：2014.7

  A phosphine-mediated synthesis of trifluoromethyl substituted pyrrole derivatives was achieved. The method described here is very fast, operationally simple, and easily amenable to scale-up, and commercially available trifluoroacetic anhydride (TFAA) is used as the only trifluoromethyl source. A wide range of products were obtained with good yields under mild condition using this method. 0(C)2014 Elsevier Ltd. All rights reserved.