Tetramethyl-chloroformamidinium | 41048-59-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Tetramethyl-chloroformamidinium
• 英文别名: [Chloro(dimethylamino)methylene]-dimethyl-ammonium；[chloro(dimethylamino)methylidene]-dimethylazanium
• CAS: 41048-59-3
• 化学式: C₅H₁₂ClN₂
• 分子量: 135.617
• InChiKey: QZFWNEASXBNLCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  6.2
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  8-氨基喹啉 、 Tetramethyl-chloroformamidinium 在 三乙胺 作用下， 以 乙腈 为溶剂， 反应 3.0h， 生成 1,1,3,3-tetramethyl-2-(quinolin-8-yl)-guanidine
  参考文献：
  名称：

  An effective non-chromatographic method for the purification of phenanthrolines and related ligands

  摘要：

  1,10-Phenanthrolines are widely employed as ligands, but their use on a large scale is constrained by their difficult purification, which usually requires lengthy chromatographic separations. Herein, we describe a purification strategy that takes advantage of the high stability and low solubility of phenanthroline complexes to separate them from the by products of their synthesis. The formation of ZnCl2 complexes was employed, from which the free ligand can be recovered by reaction with aqueous NH3 in a biphasic CH2Cl2/H2O system. The same strategy was also successfully employed to purify related quinolino-guanidine ligands, demonstrating that the procedure is of general applicability. (C) 2020 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2020.152080
• 作为产物：
  描述：

  1,1,3,3-四甲基脲 在 草酰氯 、 N,N-二甲基甲酰胺 作用下， 以 二氯甲烷 为溶剂， 生成 Tetramethyl-chloroformamidinium
  参考文献：
  名称：

  An effective non-chromatographic method for the purification of phenanthrolines and related ligands

  摘要：

  1,10-Phenanthrolines are widely employed as ligands, but their use on a large scale is constrained by their difficult purification, which usually requires lengthy chromatographic separations. Herein, we describe a purification strategy that takes advantage of the high stability and low solubility of phenanthroline complexes to separate them from the by products of their synthesis. The formation of ZnCl2 complexes was employed, from which the free ligand can be recovered by reaction with aqueous NH3 in a biphasic CH2Cl2/H2O system. The same strategy was also successfully employed to purify related quinolino-guanidine ligands, demonstrating that the procedure is of general applicability. (C) 2020 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2020.152080
• 作为试剂：
  描述：

  cis-2,6-dimethylmorpholine 在 N-甲基咪唑 、 Tetramethyl-chloroformamidinium 、 palladium 10% on activated carbon 、 氢气 、 hexafluorophosphate anion 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 反应 36.0h， 生成 2-{4-[(2R,6S)-2,6-dimethylmorpholine-4-carbonyl]piperidin-1-yl}aniline
  参考文献：
  名称：

  [EN] TRPML MODULATORS
  [FR] MODULATEURS DE TRPML

  摘要：

  本发明提供了化合物、药学上可接受的组合物以及使用这些化合物的方法。

  公开号：

  WO2021127337A1

文献信息

• [EN] SPIROLACTAM CGRP RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DE RÉCEPTEUR DE CGRP À BASE DE SPIROLACTAME
  申请人：MERCK SHARP & DOHME

  公开号：WO2013169567A1

  公开（公告）日：2013-11-14

  The present invention is directed to spirolactam analogues which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

  本发明涉及螺内酰胺类似物，其为CGRP受体拮抗剂，可用于治疗或预防涉及CGRP的疾病，如偏头痛。该发明还涉及包含这些化合物的药物组合物，以及在预防或治疗涉及CGRP的这类疾病中使用这些化合物和组合物。
• [EN] MOLECULES AND METHODS RELATED TO TREATMENT OF UNCONTROLLED CELLULAR PROLIFERATION<br/>[FR] MOLÉCULES ET PROCÉDÉS SE RAPPORTANT AU TRAITEMENT DE LA PROLIFÉRATION INCONTRÔLÉE DE CELLULES
  申请人：ST JUDE CHILDRENS RES HOSPITAL

  公开号：WO2021022076A1

  公开（公告）日：2021-02-04

  The present disclosure relates to chemical compounds that modulate cellular proliferation for the treatment of uncontrolled cellular proliferation disorders (such as cancer), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本公开涉及调节细胞增殖以治疗不受控制的细胞增殖疾病（如癌症）的化合物，含有这种化合物的药物组合物，以及它们在治疗中的应用。本摘要旨在作为在特定领域搜索的扫描工具，并不意味着对本发明的限制。
• [EN] CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS<br/>[FR] CARBOXAMIDES UTILISÉS EN TANT QUE MODULATEURS DE CANAUX SODIQUES
  申请人：VERTEX PHARMA

  公开号：WO2020146682A1

  公开（公告）日：2020-07-16

  Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

  提供了一种用作钠通道抑制剂的化合物，以及它们的药物可接受的盐。还提供了包含这些化合物或药物可接受的盐的药物组合物，以及使用这些化合物、药物可接受的盐和药物组合物治疗各种疾病，包括疼痛的方法。
• [EN] CONVERGENT AND ENANTIOSELECTIVE TOTAL SYNTHESIS OF COMMUNESIN ANALOGS<br/>[FR] SYNTHÈSE TOTALE CONVERGENTE ET ÉNANTIOSÉLECTIVE D'ANALOGUES DE LA COMMUNESINE
  申请人：MOVASSAGHI MOHAMMAD

  公开号：WO2017197045A1

  公开（公告）日：2017-11-16

  A highly convergent biomimetic synthesis of a complex polycyclic scaffold has been successfully implemented. From these efforts, compounds having a structure of Formula (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1-R8 and m, n, r, s, t, and u are as defined herein, is provided. Methods of making such compounds are also disclosed as are methods for the treatment of cancer, various infectious diseases, and abnormal cardiovascular function.

  已经成功实施了一种高度收敛的生物模拟合成方法，用以合成一个复杂的聚环支架。通过这些努力，提供了具有公式（I）结构的化合物或其药用可接受的盐、互变异构体或立体异构体，其中R1-R8以及m、n、r、s、t和u按本文定义。还公开了制造此类化合物的方法，以及用于治疗癌症、各种传染病和心血管功能异常的方法。
• [EN] NOVEL SYNTHETIC OPTIONS TOWARDS THE MANUFACTURE OF (6R,10S)-10- {4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)- PYRIMIDINYL}- 1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15 -(METHENO)PYRAZOLO [4,3-B] [1,7] DIAZACYCLOTETRADECIN-5(6H)-ONE<br/>[FR] NOUVELLES OPTIONS SYNTHÉTIQUES POUR LA FABRICATION DE (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL) PHÉNYL]-6-OXO-1(6H)-PYRIMIDINYL}1-(DIFLUOROMÉTHYL)-6-MÉTHYL-1,4,7,8,9,10-HEXAHYDRO-11,15- (METHENO)PYRAZOLO [4,3-B] [1,7] DIAZACYCLOTÉTRADECIN-5 (6H)-ONE
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2020210613A1

  公开（公告）日：2020-10-15

  Highly efficient methods are provided for preparing key intermediates in the synthesis of Compound (I), which are broadly applicable and can provide selected components having a variety of substituents groups.

  为合成化合物（I）的关键中间体提供了高效的方法，这些方法具有广泛的适用性，并且可以提供具有各种取代基团的选定组分。

表征谱图