1-amino-2-methyl-5-isopropylpyrrole | 328239-62-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1-amino-2-methyl-5-isopropylpyrrole
• 英文别名: 2-Methyl-5-propan-2-ylpyrrol-1-amine
• CAS: 328239-62-9
• 化学式: C₈H₁₄N₂
• 分子量: 138.213
• InChiKey: PCCGESRTELLLGU-UHFFFAOYSA-N

物化性质

• 沸点：
  235.7±43.0 °C(predicted)
• 密度：
  1.00±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  31
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-amino-2-methyl-5-isopropylpyrrole 在 碳酸氢钠 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 反应 6.0h， 生成
  参考文献：
  名称：

  KRAS G12C抑制剂及其在医药上的应用

  摘要：

  本发明涉及一种新型化合物，其具有KRAS G12C调节活性。本发明还涉及这些化合物的制备方法以及包含其的药物组合物。

  公开号：

  CN112390796B
• 作为产物：
  描述：

  6-甲基-2,5-庚二酮 在 盐酸 、 对甲苯磺酸 作用下， 以 1,4-二氧六环 、 乙酸乙酯 、 甲苯 为溶剂， 反应 2.0h， 生成 1-amino-2-methyl-5-isopropylpyrrole
  参考文献：
  名称：

  KRAS G12C抑制剂及其在医药上的应用

  摘要：

  本发明涉及一种新型化合物，其具有KRAS G12C调节活性。本发明还涉及这些化合物的制备方法以及包含其的药物组合物。

  公开号：

  CN112390796B

文献信息

• Catalysts for the polymerization of unsaturated compounds
  申请人：Kristen Oliver Marc

  公开号：US20050085527A1

  公开（公告）日：2005-04-21

  Bisimine compounds of the formula (I) where the symbols have the following meanings: A is a nonmetal selected from among N, S, O and P, R 1 is a radical of the formula NR 5 R 6 , R 2 is a radical of the formula NR 5 R 6 or NR 7 R 8 , alkyl, aryl or cycloalkyl, R 5 and R 6 together with the N atom form a 5-, 6- or 7-membered ring in which one or more of the —CH— or —CH 2 — groups may be replaced by suitable heteroatom groups and which may be saturated or unsaturated and unsubstituted or substituted or be fused with further carbacyclic or heterocarbacyclic 5- or 6-membered rings which may in turn be saturated or unsaturated and substituted or unsubstituted, and R 7 and R 8 are, independently of one another, alkyl, aryl or cycloalkyl radicals, and R 3 , R 4 are, independently of one another, H or alkyl, aryl or cycloalkyl radicals, and n is 1 or 2, are used to prepare bisimidinato complexes which can be used in the polymerization of unsaturated compounds.

  Bisimine化合物的化学式（I）中，符号的含义如下：A是从N、S、O和P中选取的非金属，R1是化学式NR5R6的基团，R2是化学式NR5R6或NR7R8、烷基、芳基或环烷基的基团，R5和R6与N原子一起形成一个5、6或7元环，其中一个或多个—CH—或—CH2—基团可被适当的杂原子基团取代，环可以饱和或不饱和、未取代或取代，或与进一步的碳环或杂碳环的5或6元环融合，后者可以饱和或不饱和、取代或未取代，R7和R8是彼此独立的烷基、芳基或环烷基基团，R3、R4是彼此独立的H或烷基、芳基或环烷基基团，n为1或2，用于制备可用于聚合不饱和化合物的双咪唑配合物。
• Organic thin-film transistor and method for manufacturing same
  申请人：FUJIFILM Corporation

  公开号：US10008671B2

  公开（公告）日：2018-06-26

  Provided are an organic thin-film transistor including: a gate electrode, an organic semiconductor layer, a gate insulating layer, and a source electrode and a drain electrode on a substrate, in which the organic semiconductor layer contains an organic semiconductor and a block copolymer, and the block copolymer is at least one selected from specific block copolymers such as a styrene-(meth)acrylate ester block copolymer and may be phase-separated, and a method for manufacturing an organic thin-film transistor, which includes an organic semiconductor containing a phase-separated block copolymer, including: applying a coating solution which contains an organic semiconductor and a block copolymer for film formation; and heating the obtained film so that the block copolymer is self-assembled.

  提供了一种有机薄膜晶体管，包括：栅极、有机半导体层、栅极绝缘层以及基底上的源电极和漏电极，其中有机半导体层包含有机半导体和嵌段共聚物，嵌段共聚物至少是选自特定嵌段共聚物（如苯乙烯-（甲基）丙烯酸酯嵌段共聚物）中的一种，并且可以是相分离的；以及一种制造有机薄膜晶体管的方法，其中包括含有相分离嵌段共聚物的有机半导体，包括： 1：涂敷含有有机半导体和嵌段共聚物的涂层溶液，以形成薄膜；以及加热获得的薄膜，使嵌段共聚物自组装。
• Organic semiconductor element, organic semiconductor composition, method of manufacturing organic semiconductor film, organic semiconductor film, and compound and polymer using the same
  申请人：FUJIFILM Corporation

  公开号：US11081651B2

  公开（公告）日：2021-08-03

  An organic semiconductor element in which an organic semiconductor layer contains a compound of Formula (1), a compound of Formula (2), and/or a compound of Formula (3) or contains a polymer having a structure of any one of formed by Formulae (8) to (10): in which X1 represents a nitrogen atom or CRa, and rings A to B each represent a specific nitrogen-containing ring; Y1 represents an oxygen atom, a sulfur atom, CRb2, or NRc; V1 represents NRd, an oxygen atom, a sulfur atom, or a selenium atom; Ra to Rd each represent a hydrogen atom or a substituent; R1 represents a specific substituent, and p is an integer of 0 to 2; n represents 1 or 2; and * represents a bonding site.

  一种有机半导体元件，其中有机半导体层含有式(1)化合物、式(2)化合物和/或式(3)化合物，或含有具有式(8)至式(10)中任何一种结构的聚合物： 其中，X1 代表氮原子或 CRa，环 A 至 B 各代表一个特定的含氮环；Y1 代表氧原子、硫原子、CRb2 或 NRc；V1 代表 NRd、氧原子、硫原子或硒原子；Ra 至 Rd 各代表氢原子或取代基；R1 代表一个特定的取代基，p 为 0 至 2 的整数；n 代表 1 或 2；* 代表键合位点。
• BISIMIDINOVERBINDUNGEN UND IHRE ÜBERGANGSMETALLKOMPLEXE SOWIE DEREN VERWENDUNG ALS KATALYSATOREN
  申请人：BASF AKTIENGESELLSCHAFT

  公开号：EP1204668B1

  公开（公告）日：2003-04-02
• SEMICONDUCTOR DEVICE AND INSULATING LAYER-FORMING COMPOSITION
  申请人：FUJIFILM Corporation

  公开号：US20170054076A1

  公开（公告）日：2017-02-23

  Provided is a semiconductor device which includes a semiconductor layer and an insulating layer adjacent to the semiconductor layer, in which the insulating layer is formed of a crosslinked product of a polymer compound that has a repeating unit (IA) represented by the following Formula (IA) and a repeating unit (IB) represented by the following Formula (IB); and an insulating layer-forming composition which is used for forming an insulating layer of a semiconductor device and contains a polymer compound that has the following repeating units (IA) and (IB). In Formulae, R 1a and R 1b each independently represent a hydrogen atom, a halogen atom, or an alkyl group. L 1a , L 2a , and L 1b each independently represent a single bond or a linking group. X represents a crosslinkable group and Y B represents a decomposable group or a hydrogen atom. m1a and m2a each independently represent an integer of 1 to 5. The symbol “*” represents a bonding position of the repeating units.