4-(phenyltellanyl)butanenitrile | 1380435-02-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(phenyltellanyl)butanenitrile
• 英文别名: 4-Phenyltellanylbutanenitrile；4-phenyltellanylbutanenitrile
• CAS: 1380435-02-8
• 化学式: C₁₀H₁₁NTe
• 分子量: 272.804
• InChiKey: XGYFXWGDBCWQAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.74
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-(phenyltellanyl)butanenitrile 在 sodium azide 、 zinc dibromide 作用下， 以 水 为溶剂， 反应 24.0h， 以65%的产率得到C₁₀H₁₂N₄Te
  参考文献：
  名称：

  Synthesis of novel selenium and tellurium-containing tetrazoles: a class of chalcogen compounds with antifungal activity

  摘要：

  We describe herein the synthesis and antifungal activity of new 5-arylchalcogenoalkyl-1H-tetrazoles 4. Arylchalcogenoalkyl-1H-tetrazoles 4 have been synthesized in high yields by reaction of arylchalcogenolate anions with chloronitriles 2, and subsequent [2+3] cycloaddition of resulting arylchalcogenoalkylnitriles 3 with sodium azide by zinc catalysis in aqueous solution. The obtained compound 4a was screened for antifungal activity and presented inhibitory property against seven fungal strains. This protocol is an efficient method to produce new selenium-nitrogen compounds with antifungal activity. (C) 2012 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2012.04.040
• 作为产物：
  描述：

  碘苯 在 碲化氢 、 copper(II) oxide 、 potassium hydroxide 作用下， 以 二甲基亚砜 为溶剂， 生成 4-(phenyltellanyl)butanenitrile
  参考文献：
  名称：

  环酮肟酯与二硫属化物的无金属硫族化

  摘要：

  我们报告了环酮肟酯与二硫属化物通过自由基过程的无金属硫族化。由于无金属条件和使用容易获得的二硫属元素化物，该方法是合成硫属元素取代丁腈的有效且绿色的策略。

  DOI：

  10.1016/j.tetlet.2021.153202

文献信息

• Additive‐Free Generation of Cyanoalkyl Radicals via Photoinduced Single Electron Transfer from Dichalcogenides to Cycloketone Oxime Esters
  作者：Xiao‐Di Su、Bei‐Bei Zhang、Qiang Liu、Zhu‐Sheng Yang、Zhi‐Xiang Wang、Xiang‐Yu Chen

  DOI：10.1002/ejoc.202200890

  日期：2022.11.7

  A photoactive charge transfer complex protocol for the generation of cyanoalkyl radicals from cyclobutanone oxime esters with dichalcogenides is established.

  建立了从环丁酮肟酯与二硫属化物生成氰烷基自由基的光活性电荷转移复合物方案。
• Metal-free chalcogenation of cycloketone oxime esters with dichalcogenides
  作者：Liangshuo Ji、Jiamin Qiao、Junjie Liu、Miaomiao Tian、Kui Lu、Xia Zhao

  DOI：10.1016/j.tetlet.2021.153202

  日期：2021.7

  We report the metal-free chalcogenation of cycloketone oxime esters with dichalcogenides via a radical process. Because of the metal-free condition and use of readily accessible dichalcogenides, this method is an effective and green strategy for the synthesis of chalcogen-substituted butyronitrile.

  我们报告了环酮肟酯与二硫属化物通过自由基过程的无金属硫族化。由于无金属条件和使用容易获得的二硫属元素化物，该方法是合成硫属元素取代丁腈的有效且绿色的策略。
• Synthesis of novel selenium and tellurium-containing tetrazoles: a class of chalcogen compounds with antifungal activity
  作者：Francieli M. Libero、Maurício C.D. Xavier、Francine N. Victoria、Patrícia S. Nascente、Lucielli Savegnago、Gelson Perin、Diego Alves

  DOI：10.1016/j.tetlet.2012.04.040

  日期：2012.6

  We describe herein the synthesis and antifungal activity of new 5-arylchalcogenoalkyl-1H-tetrazoles 4. Arylchalcogenoalkyl-1H-tetrazoles 4 have been synthesized in high yields by reaction of arylchalcogenolate anions with chloronitriles 2, and subsequent [2+3] cycloaddition of resulting arylchalcogenoalkylnitriles 3 with sodium azide by zinc catalysis in aqueous solution. The obtained compound 4a was screened for antifungal activity and presented inhibitory property against seven fungal strains. This protocol is an efficient method to produce new selenium-nitrogen compounds with antifungal activity. (C) 2012 Published by Elsevier Ltd.