3-chloro-4-(methylsulfonyl)benzaldehyde | 101349-83-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-chloro-4-(methylsulfonyl)benzaldehyde
• 英文别名: 3-chloro-4-methanesulfonyl-benzaldehyde；3-chloro-4-methylsulfonylbenzaldehyde
• CAS: 101349-83-1
• 化学式: C₈H₇ClO₃S
• 分子量: 218.661
• InChiKey: BKKXQNYUVCDQRJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  59.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-chloro-4-(methylsulfonyl)benzaldehyde 在 ammonium acetate 、 溴 、 铁粉 、 溶剂黄146 作用下， 以 1,4-二氧六环 为溶剂， 生成 1-Bromo-1-(3-chloro-4-methylsulfonylphenyl)propan-2-one
  参考文献：
  名称：

  Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway

  摘要：

  Using a parallel synthesis approach to target a non-conserved region of the PI3K catalytic domain a pan-PI3K inhibitor 1 was elaborated to provide alpha, delta and gamma isoform selective Class I PI3K inhibitors 21, 24, 26 and 27. The compounds had good cellular activity and were selective against protein kinases and other members of the PI3K superfamily including mTOR and DNA-PK. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.07.042
• 作为产物：
  描述：

  3-氯-4-氟苯甲醛 、 sodium methansulfinate 以 二甲基亚砜 为溶剂， 生成 3-chloro-4-(methylsulfonyl)benzaldehyde
  参考文献：
  名称：

  [EN] SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AND METHODS OF USE THEREOF
  [FR] DÉRIVÉS DE BENZOTHIOPHÈNE SUBSTITUÉS ET LEURS PROCÉDÉS D'UTILISATION

  摘要：

  本文提供了新颖的式 (I) 取代的噻吩衍生物及其药学上可接受的盐，其中 R1、R2、R3、R4 和 R7 如本文所定义；还提供了包含至少一种取代的噻吩衍生物的组合物，以及使用取代的噻吩衍生物治疗或预防患者癌症的方法。

  公开号：

  WO2023121939A1

文献信息

• Diaminopyrimidine derivatives as growth hormone secrectgogue receptor (GHS-R) antagonists
  申请人：Kosogof Christi

  公开号：US20050171131A1

  公开（公告）日：2005-08-04

  The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the action of ghrelin receptor, including Prader-Willi syndrome, eating disorder, weight gain, weight-loss maintainance following diet and exercise, obesity, and disorders associated with obesity such as noninsulin dependent diabetes mellitus.

  本发明涉及式(I)的化合物，或其治疗上适用的盐或前药，所述化合物的制备，含有所述化合物的组合物以及在预防或治疗由胃泌素受体调节的疾病中使用所述化合物，包括普拉德-威利综合征、进食障碍、体重增加、饮食和锻炼后体重减轻维持、肥胖，以及与肥胖相关的疾病，如非胰岛素依赖型糖尿病。
• Substituted &bgr; diketones and their use
  申请人：Orion Corporation

  公开号：US06201027B1

  公开（公告）日：2001-03-13

  The invention relates to the compounds of formula I: wherein one of X1 and X2 is MeSO2 and the other one is hydrogen or halogen and X3 is hydrogen or halogen. These compounds have been found to be useful in the prevention and the treatment of respiratory diseases, especially asthma, ARDS (Acute Respiratory Distress Syndrome), COPD (chronic obstructive pulmonary diseases), allergic rhinitis and related inflammatory conditions. More specifically, the invention relates to the use of said compound in the prevention and the treatment of asthma in steroid-resistant patients. The invention also relates to pharmaceutical formulations used in the treatment of said diseases.

  该发明涉及式I的化合物：其中X1和X2中的一个是MeSO2，另一个是氢或卤素，X3是氢或卤素。已发现这些化合物在预防和治疗呼吸道疾病，特别是哮喘、ARDS（急性呼吸窘迫综合征）、COPD（慢性阻塞性肺疾病）、过敏性鼻炎和相关炎症症状方面具有用途。更具体地，该发明涉及在类固醇耐药患者中预防和治疗哮喘的所述化合物的使用。该发明还涉及用于治疗上述疾病的药物配方。
• [EN] 5-PHENYLTHIAZOLE DERIVATIVES AND THEIR USE AS P13 KINASE INHIBITORS<br/>[FR] DERIVES DE 5-PHENYLTHIAZOLE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE PI3 KINASE
  申请人：NOVARTIS AG

  公开号：WO2004078754A1

  公开（公告）日：2004-09-16

  Compounds of formula (I) in free or salt form, wherein R1, R2, R3, Wand R5 have the meanings as indicated in the specification, are useful for treating diseases mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

  式（I）中的化合物以自由形式或盐形式存在，其中R1、R2、R3、W和R5的含义如规范中所示，用于治疗由磷脂酰肌醇3-激酶介导的疾病。还描述了含有这些化合物的药物组合物和制备这些化合物的方法。
• 5-Phenylthiazole derivatives and their use as p13 kinase inhibitors
  申请人：Novartis AG

  公开号：US08017608B2

  公开（公告）日：2011-09-13

  Compounds of formula I in free or salt form, wherein R1, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating diseases mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

  式I的化合物，无论是自由形式还是盐形式，其中R1、R2、R3、R4和R5的含义如说明书所示，对于治疗由磷脂酰肌醇3-激酶介导的疾病是有用的。还描述了包含该化合物的制药组合物以及制备该化合物的过程。
• Indole and azaindole haloallylamine derivative inhibitors of lysyl oxidases and uses thereof
  申请人：PHARMAXIS LTD.

  公开号：US10717734B2

  公开（公告）日：2020-07-21

  The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human subjects as well as in pets and livestock. In addition, the present invention relates to pharmaceutical compositions containing these compounds, as well as various uses thereof.

  本发明涉及能够抑制某些胺氧化酶的新型化合物。这些化合物可用于治疗各种适应症，如人类、宠物和家畜的纤维化、癌症和/或血管生成。此外，本发明还涉及含有这些化合物的药物组合物及其各种用途。