N-[(2-Hydroxyphenyl)acetyl]glycine | 16555-82-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[(2-Hydroxyphenyl)acetyl]glycine
• 英文别名: 2-[[2-(2-hydroxyphenyl)acetyl]amino]acetic acid
• CAS: 16555-82-1
• 化学式: C₁₀H₁₁NO₄
• 分子量: 209.2
• InChiKey: NVQIOKSGUVRTBV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  86.6
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Trimethylamine-N-oxide as biomarker for the predisposition for weight gain and obesity
  申请人：Nestec S.A.

  公开号：US10094819B2

  公开（公告）日：2018-10-09

  The present invention relates generally to the field of nutrition and health. In particular, the present invention relates to a new biomarker, its use and a method that allows it to diagnose the likelihood to resist diet induced weight gain, and/or to be susceptible to a diet induced weight gain. For example, the biomarker may be trimethylamine-N-oxide.

  本发明一般涉及营养和健康领域。特别是，本发明涉及一种新的生物标志物、其用途和方法，该生物标志物可用于诊断抵抗节食引起的体重增加的可能性和/或易受节食引起的体重增加影响的可能性。例如，生物标志物可以是三甲胺-N-氧化物。
• Paramagnetic metal ion-based macrocylic magnetization transfer contrast agents and method of use
  申请人：Board of Regents, The University of Texas System

  公开号：US20020127182A1

  公开（公告）日：2002-09-12

  The present invention is directed, in general, to contrast agents (CA), and methods and systems of using such agents for producing image contrast based on a magnetization transfer (MT) mechanism. The CA comprises a tetraazacyclododecane ligand having pendent arms R, R′, R″ and R″′ that are amides having a general formula: —CR 1 H—CO—NH—CH 2 —R 2 . R 1 includes organic substituents and R 2 is not hydrogen. A paramagnetic metal ion (M) is coordinated to the ligand. The method, comprises subjecting a CA, in a sample, to a radio frequency pulse. The CA has pendent arms R, R′, R″ and R″′ comprising organic substituents and the ligand further includes a M and a water molecule. A signal is obtained by applying a radio frequency pulse at a resonance frequency of the water molecule. The magnetic resonance system, comprises a magnetic resonance apparatus and the CA, the agent containing a ligand having the above described general formula.

  本发明一般涉及造影剂（CA），以及使用这种造影剂产生基于磁化转移（MT）机制的图像对比的方法和系统。CA 包括四氮杂环十二烷配体，该配体具有下垂臂 R、R′、R″和 R″′，它们是具有通式的酰胺：-R 1 H-CO-NH-CH 2 -R 2 .R 1 包括有机取代基，R 2 不是氢。顺磁性金属离子（M）与配体配位。该方法包括将样品中的 CA置于射频脉冲下。CA 具有由有机取代基组成的垂臂 R、R′、R″和 R″′，配体还包括 M 和水分子。通过在水分子的共振频率上施加射频脉冲可获得信号。磁共振系统，包括磁共振装置和 CA，该剂含有具有上述通式的配体。
• PARAMAGNETIC METAL ION-BASED MACROCYLIC CONTRAST AGENTS
  申请人：Board of Regents University of Texas System

  公开号：EP1390079A2

  公开（公告）日：2004-02-25
• HEXANOYLGLYCINE AS BIOMARKER FOR THE PREDISPOSITION FOR WEIGHT GAIN AND OBESITY
  申请人：Nestec S.A.

  公开号：EP2929353B1

  公开（公告）日：2017-05-10
• TRIMETHYLAMINE-N-OXIDE AS BIOMARKER FOR THE PREDISPOSITION FOR WEIGHT GAIN AND OBESITY
  申请人：Nestec S.A.

  公开号：EP2929347A1

  公开（公告）日：2015-10-14