bis-(3t-chloro-allyl)-ether | 21960-87-2

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 乙烯基卤化物
• 英文名称: bis-(3t-chloro-allyl)-ether
• 英文别名: Bis-(3t-chlor-allyl)-aether；(E)-1-chloro-3-[(E)-3-chloroprop-2-enoxy]prop-1-ene
• CAS: 21960-87-2
• 化学式: C₆H₈Cl₂O
• 分子量: 167.035
• InChiKey: FIKDRSSZQXZDHK-ZPUQHVIOSA-N

物化性质

• 沸点：
  88-91 °C(Press: 15 Torr)
• 密度：
  1.207 g/cm3(Temp: 17 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  反式-1,3-二氯-1-丙烯 在 氢氧化钾 作用下， 生成 (E)-3-chloroallyl alcohol 、 bis-(3t-chloro-allyl)-ether
  参考文献：
  名称：

  Vessiere, Bulletin de la Societe Chimique de France, 1959, p. 1268,1272

  摘要：

  DOI：

文献信息

• METHOD OF PRODUCING PYRONE AND PYRIDONE DERIVATIVES
  申请人：Sumino Yukihito

  公开号：US20120022251A1

  公开（公告）日：2012-01-26

  The present invention provides a pyrone derivative and a pyridone derivative, which are novel intermediates for synthesizing an anti-influenza drug, a method of producing the same, and a method of using the same.

  本发明提供了一种吡喃衍生物和一种吡啶酮衍生物，它们是合成抗流感药物的新型中间体，以及其制备方法和使用方法。
• [EN] METHOD OF THE SYNTHESIS OF DIALKYL HALOALKYLPHOSPHONATES AND DIALKYL HALOALKYLOXYALKYLPHOSPHONATES<br/>[FR] PROCÉDÉ DE SYNTHÈSE DES DIALKYL HALOGÉNOALKYLPHOSPHONATES ET DES DIALKYL HALOGÉNOALKYLOXYALKYLPHOSPHONATES
  申请人：USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE VED CESKE REPUBLIKY V V I

  公开号：WO2012013168A1

  公开（公告）日：2012-02-02

  The invention deals with the method of the synthesis of dialkyl haloalkylphosphonates and dialkyl haloalkyloxyalkylphosphonates via a microwave-heated Michaelis-Arbuzov reaction of trialkylphosphites with dihaloalkanes or bis(haloalkyl)ethers in a closed vessel, during which the reaction mixture, containing a dihaloalkane or bis(haloalkyl)ether and a trialkylphosphite, is heated with microwave radiation with the standard frequency (2.45 GHz) to reach a reaction temperature which is specific for each individual halogen. In the subsequent reaction of the first dihaloalkane or bis(haloalkyl)ether halogen atom with trialkyl phosphite, the desired dialkyl haloalkylphosphonate or dialkyl haloalkyloxyalkylphosphonate is formed, but the reaction of its halogen atom with the so-far present trialkylphosphite, leading to the creation of the relevant bisphosphonate, no longer takes place. In the case of an inhomogeneous reaction mixture, also the desired product in the amount of 0.1-5 molar % is added to the reaction mixture for its homogenization, which homogenizes it and thus precludes its uncontrollable overheating. The entire process of synthesis is more effective, faster, less expensive and more environmentally friendly than the methods described so far in the literature. The possibility of performing the described procedure also in a continuous-flow microwave reactor allows industrial production with minimal demands on an optimization of the reaction conditions for larger quantities, eliminates some security risks, dramatically reduces the spatial demands in production and reduces the need for the usage of large-tonnage industrial reactors.

  该发明涉及通过微波加热的Michaelis-Arbuzov反应，在封闭容器中合成二烷基卤代烷基膦酸酯和二烷基卤代烷氧基烷基膦酸酯的方法。在反应过程中，包含二烷基卤代烷基膦酸酯和三烷基膦酸酯的反应混合物通过微波辐射加热至标准频率（2.45 GHz）的反应温度，该温度对于每种卤素都是特定的。在第一个二烷基卤代烷基膦酸酯或二烷基卤代烷氧基烷基膦酸酯的卤原子与三烷基膦酸酯的反应中，形成所需的二烷基卤代烷基膦酸酯或二烷基卤代烷氧基烷基膦酸酯，但其卤原子与迄今为止存在的三烷基膦酸酯的反应，导致相关双膦酸酯的生成，不再发生。在反应混合物不均匀的情况下，还向反应混合物中添加所需产品的0.1-5摩尔%的量以使其均匀化，从而防止其不受控制地过热。整个合成过程比文献中迄今描述的方法更有效、更快、更经济、更环保。在连续流动微波反应器中执行所述程序的可能性使得工业生产具有最小的反应条件优化要求，消除了一些安全风险，显著减少了生产中的空间需求，并减少了对大吨位工业反应器的使用需求。
• SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PRODRUG
  申请人：Takahashi Chika

  公开号：US20130197219A1

  公开（公告）日：2013-08-01

  The present invention provides a compound having antiviral effects, particularly having growth inhibitory activity on influenza viruses, a preferred example of the compound being a substituted 3-hydroxy-4-pyridone derivative prodrug having cap-dependent endonuclease inhibitory activity.

  本发明提供了一种具有抗病毒效果的化合物，特别是对流感病毒具有生长抑制活性，该化合物的首选例子是一种具有依赖帽端核酸酶抑制活性的取代3-羟基-4-吡啶酮衍生物前药。
• Modified nucleosides for the treatment of viral infections and abnormal cellular proliferation
  申请人：——

  公开号：US20030087873A1

  公开（公告）日：2003-05-08

  The disclosed invention is a composition for and a method of treating a Flaviviridae (including BVDV and HCV), Orthomyxoviridae (including Influenza A and B) or Paramyxoviridae (including RSV) infection, or conditions related to abnormal cellular proliferation, in a host, including animals, and especially humans, using a nucleoside of general formula (I)-(XXIII) or its pharmaceutically acceptable salt or prodrug. This invention also provides an effective process to quantify the viral load, and in particular BVDV, HCV or West Nile Virus load, in a host, using real-time polymerase chain reaction (“RT-PCR”). Additionally, the invention discloses probe molecules that can fluoresce proportionally to the amount of virus present in a sample.

  该公开的发明涉及一种用于治疗Flaviviridae（包括BVDV和HCV）、Orthomyxoviridae（包括甲型和乙型流感）或Paramyxoviridae（包括RSV）感染或与异常细胞增殖有关的病况的组合物和方法，适用于宿主，包括动物，尤其是人类，使用通用式（I）-（XXIII）的核苷或其药学上可接受的盐或前药。该发明还提供了一种有效的过程，用于量化病毒载量，特别是BVDV、HCV或西尼罗河病毒载量，使用实时聚合酶链反应（RT-PCR）。此外，该发明揭示了可以与样本中存在的病毒数量成比例发光的探针分子。
• Terminally-branched polymeric linkers containing extension moieties and polymeric conjugates containing the same
  申请人：——

  公开号：US20020015691A1

  公开（公告）日：2002-02-07

  E 1a-3a are independently selected from the group consisting of hydrogen, C 1-6 alkyls, C 3-12 branched alkyls, C 3-8 cycloalkyls, C 1-6 substituted alkyls, C 3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C 1-6 heteroalkyls, substituted C 1-6 heteroalkyls, C 1-6 alkoxy, phenoxy, C 1-6 heteroalkoxy, 1 wherein B 1 is a leaving group, OH, a residue of a hydroxyl-containing moiety or a residue of an amine-containing moiety or 2 wherein E 6 is independently selected from the same group which defines 3 wherein E 1b-3b are independently selected from the group consisting of hydrogen, C 1-6 alkyls, C 3-12 branched alkyls, C 3-8 cycloalkyls, C 1-6 substituted alkyls, C 3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C 1-6 heteroalkyls, substituted C 1-6 heteroalkyls, C 1-6 alkoxy, phenoxy, C 1-6 heteroalkoxy, 4 wherein B 2 is a leaving group, OH, a residue of a hydroxyl-containing moiety or a residue of an amine-containing moiety; G is a polymeric residue; Y 1-3, Y 2a-d and Y 3a-d are each independently O, S or NR 11a M 1-4 , M 2a-2d , M 3a-3d , and M 4a-4d are each independently O, S or NR 11b ; M 5 and M 5a-d are each independently X or Q, wherein X is an electron withdrawing group and Q is a moiety containing a free electron pair positioned three to six atoms from C(═Y 3 ) or C(═Y 3a-d ); R 1-10 , R 1a-11a , R 1b-11b , R 1c-10c and R 1d-10d are each independently selected from the group consisting of hydrogen, C 1-6 alkyls, C 3-12 branched alkyls, C 3-8 cycloalkyls, C 1-6 substituted alkyls, C 3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C 1-6 heteroalkyls, substituted C 1-6 heteroalkyls, C 1-6 alkoxy, phenoxy and C 1-6 heteroalkoxy; and a, b, c, d1-d6, e1-e6, f1-f6, g1-g6, h1-h6, i1-i6, j1-j6, k1-k6, l1-l6, m1-m6 are each independently zero or a positive integer.

  E1a-3a分别独立选自氢、C1-6烷基、C3-12支链烷基、C3-8环烷基、C1-6取代烷基、C3-8取代环烷基、芳基、取代芳基、芳基烷基、C1-6杂原子烷基、取代的C1-6杂原子烷基、C1-6烷氧基、苯氧基、C1-6杂原子烷氧基；其中B1是一个脱离基团、OH、含羟基团的残基或含胺基团的残基；E6独立选自定义3的相同组中；E1b-3b独立选自氢、C1-6烷基、C3-12支链烷基、C3-8环烷基、C1-6取代烷基、C3-8取代环烷基、芳基、取代芳基、芳基烷基、C1-6杂原子烷基、取代的C1-6杂原子烷基、C1-6烷氧基、苯氧基、C1-6杂原子烷氧基；其中B2是一个脱离基团、OH、含羟基团的残基或含胺基团的残基；G是聚合物残基；Y1-3、Y2a-d和Y3a-d分别独立为O、S或NR11a；M1-4、M2a-2d、M3a-3d和M4a-4d分别独立为O、S或NR11b；M5和M5a-d分别独立为X或Q，其中X是一个电子吸引基团，Q是一个含有自由电子对的团，其位置距离C(═Y3)或C(═Y3a-d)三到六个原子；R1-10、R1a-11a、R1b-11b、R1c-10c和R1d-10d分别独立选自氢、C1-6烷基、C3-12支链烷基、C3-8环烷基、C1-6取代烷基、C3-8取代环烷基、芳基、取代芳基、芳基烷基、C1-6杂原子烷基、取代的C1-6杂原子烷基、C1-6烷氧基、苯氧基和C1-6杂原子烷氧基；a、b、c、d1-d6、e1-e6、f1-f6、g1-g6、h1-h6、i1-i6、j1-j6、k1-k6、l1-l6、m1-m6分别独立为零或正整数。