Dodecanoic acid, 10-bromo-12,12,12-trichloro-, methyl ester | 65808-38-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Dodecanoic acid, 10-bromo-12,12,12-trichloro-, methyl ester
• 英文别名: methyl 10-bromo-12,12,12-trichlorododecanoate
• CAS: 65808-38-0
• 化学式: C₁₃H₂₂BrCl₃O₂
• 分子量: 396.579
• InChiKey: OWOQQLQIQADZRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  19
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  三氯溴甲烷 、 10-烯酸甲酯 在 1,1'-双(二苯基膦)二茂铁 、 二(氰基苯)二氯化钯 二乙胺 作用下， 以 水 为溶剂， 反应 10.0h， 以70%的产率得到Dodecanoic acid, 10-bromo-12,12,12-trichloro-, methyl ester
  参考文献：
  名称：

  A Room Temperature Kharasch Reaction Catalyzed by Pd(0) in a Heterogeneous Aqueous System

  摘要：

  The palladium-catalyzed Kharasch reaction of alkenes and alkynes is enhanced by the use of a heterogeneous aqueous system, without the use of hydrophilic co-solvents or phase transfer catalysts. The Pd(0)-catalyzed reaction of terminal alkenes with bromotrichloromethane in water goes to completion within 2 h at room temperature, whereas no reaction occurs in benzene otherwise under the same conditions. The Pd(0) catalyst in aqueous me la a so effects the radical addition of iodoperfluoroalkanes toward terminal alkenes and alkynes at room temperature.

  DOI：

  10.1002/1615-4169(200206)344:3/4<261::aid-adsc261>3.0.co;2-7

文献信息

• A Room Temperature Kharasch Reaction Catalyzed by Pd(0) in a Heterogeneous Aqueous System
  作者：Dai Motoda、Hidenori Kinoshita、Hiroshi Shinokubo、Koichiro Oshima

  DOI：10.1002/1615-4169(200206)344:3/4<261::aid-adsc261>3.0.co;2-7

  日期：2002.6

  The palladium-catalyzed Kharasch reaction of alkenes and alkynes is enhanced by the use of a heterogeneous aqueous system, without the use of hydrophilic co-solvents or phase transfer catalysts. The Pd(0)-catalyzed reaction of terminal alkenes with bromotrichloromethane in water goes to completion within 2 h at room temperature, whereas no reaction occurs in benzene otherwise under the same conditions. The Pd(0) catalyst in aqueous me la a so effects the radical addition of iodoperfluoroalkanes toward terminal alkenes and alkynes at room temperature.