methyl 2-((2-bromobenzyl)amino)acetate | 852358-46-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl 2-((2-bromobenzyl)amino)acetate
• 英文别名: Methyl (2-bromobenzyl)glycinate；methyl 2-[(2-bromophenyl)methylamino]acetate
• CAS: 852358-46-4
• 化学式: C₁₀H₁₂BrNO₂
• mdl: MFCD11140668
• 分子量: 258.115
• InChiKey: ZMBGVIOOMTXNSG-UHFFFAOYSA-N

物化性质

• 沸点：
  313.7±27.0 °C(Predicted)
• 密度：
  1.404±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl 2-((2-bromobenzyl)amino)acetate 在 N-甲基吗啉 、 盐酸 、 sodium cyanoborohydride 、 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 作用下， 以 二氯甲烷 、 水 、 乙腈 为溶剂， 反应 3.5h， 生成 L-N-2-bromobenzyl-N-methyl-Cly-N'-3-(trimethylsilyl)propargyl-Gly-OMe
  参考文献：
  名称：

  Application of Peptidyl Radicals into a New Radical Cascade Leading to Unsaturated γ-Lactams

  摘要：

  Radical cyclization of dipeptides 1a-h proceeds smoothly to give five- and seven-membered rings in good to moderate total yields using Stork's catalytic tin hydride method. A radical is generated on a protecting group and translocated to the peptide moiety. Following a cyclization reaction, the vinyl radical can abstract hydrogen from a benzyl group on an amine, which results in elimination of the protected amine group. Encouraging results have notably been obtained with amino acids other than glycine.

  DOI：

  10.1021/jo020602w
• 作为产物：
  描述：

  {[1-(2-Bromo-phenyl)-meth-(E)-ylidene]-amino}-acetic acid methyl ester 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 4.0h， 生成 methyl 2-((2-bromobenzyl)amino)acetate
  参考文献：
  名称：

  Application of Peptidyl Radicals into a New Radical Cascade Leading to Unsaturated γ-Lactams

  摘要：

  Radical cyclization of dipeptides 1a-h proceeds smoothly to give five- and seven-membered rings in good to moderate total yields using Stork's catalytic tin hydride method. A radical is generated on a protecting group and translocated to the peptide moiety. Following a cyclization reaction, the vinyl radical can abstract hydrogen from a benzyl group on an amine, which results in elimination of the protected amine group. Encouraging results have notably been obtained with amino acids other than glycine.

  DOI：

  10.1021/jo020602w

文献信息

• [EN] HETEROCYCLIC SPIRO-COMPOUNDS AS AM2 RECEPTOR INHIBITORS<br/>[FR] COMPOSÉS SPIRO HÉTÉROCYCLIQUES CONSTITUANT DES INHIBITEURS DU RÉCEPTEUR DE L'AM2
  申请人：UNIV SHEFFIELD

  公开号：WO2020099885A1

  公开（公告）日：2020-05-22

  Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: wherein R1, R2, R4, R5, R6, R7, R8, R9, R10,Z, X1, X2, X3, L2, HET, n and q are as defined herein. The compounds are inhibitors of adrenomedullin receptor subtype 2 (AM2). Also disclosed are the compounds for use in the treatment of diseases modulated AM2, including proliferative diseases such as cancer; pharmaceutical compositions comprising the compounds; methods for preparing the compounds; and intermediates useful in the preparation of the compounds.

  揭示了以下式（I）的化合物及其药学上可接受的盐：其中R1、R2、R4、R5、R6、R7、R8、R9、R10、Z、X1、X2、X3、L2、HET、n和q如本文所定义。这些化合物是肾上腺髓质素受体亚型2（AM2）的抑制剂。还揭示了这些化合物用于治疗调节AM2的疾病，包括增殖性疾病如癌症；包含这些化合物的药物组合物；制备这些化合物的方法；以及制备这些化合物的有用中间体。
• Expedient Syntheses of Sulfonylhydantoins and Two Six-Membered Analogues
  作者：Andrew D. Campbell、Alan M. Birch

  DOI：10.1055/s-2005-863735

  日期：——

  A range of α-amino esters can be turned into sulfonyl­hydantoins 2 in a single, atom-economic step using sulfamide and DBU. This procedure obviates the need for a three- or four-step sequence utilised by traditional procedures. Two new six-membered analogues 3 and 4 have also been prepared utilising novel synthetic protocols.

  一系列α-氨基酯可以通过使用磺酰胺和DBU在一个原子经济的步骤中转化为磺酰氨基脲2。这种方法消除了传统程序所需的三步或四步序列。还利用新颖的合成方法制备了两个新的六元环类化合物3和4。
• Synthesis of new 8-arylisoquinoline derivatives by application of palladium-catalyzed Suzuki cross-coupling reactions
  作者：Inmaculada Andreu、Nuria Cabedo、Frédéric Fabis、Diego Cortes、Sylvain Rault

  DOI：10.1016/j.tet.2005.06.025

  日期：2005.8

  and 8-phenylisoquinolin-4-ol (17), flexible analogues of aporphine, were synthesized in good yields using palladium-catalyzed Suzuki cross-coupling reactions from 8-bromotetrahydroisoquinolin-4-one (6) as a common intermediate. We also describe the synthesis of this novel intermediate through an easy and efficient method, which involved intramolecular Friedel–Crafts cyclization.

  新8-（HET）aryltetrahydroisoquinolines（10 - 14），8-aryltetrahydroisoquinolin -4-醇（15，16），和8-苯基异-4-醇（17），阿朴啡的柔性类似物，在使用钯良好的收率合成催化的8-溴四氢异喹啉-4-酮（6）作为常见中间体的铃木交叉偶联反应。我们还描述了通过一种简单有效的方法合成这种新型中间体的方法，该方法涉及分子内Friedel-Crafts环化。
• WO2018211275A5
  申请人：——

  公开号：WO2018211275A5

  公开（公告）日：2022-11-22
• Selective Synthesis of Either Isoindole- or Isoindoline-1-carboxylic Acid Esters by Pd(0)-Catalyzed Enolate Arylation
  作者：Daniel Solé、Olga Serrano

  DOI：10.1021/jo101054j

  日期：2010.9.17

  Two efficient palladium-catalyzed intramolecular alpha-arylation reactions of alpha-amino acid esters have been developed that allow either 1-isoindolecarboxylic acid esters or the corresponding isoindolines to be selectively synthesized simply by a slight change of reaction conditions.