8-hydroxy-1H-isochromen-1-one | 4702-36-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异香豆素及其衍生物
• 英文名称: 8-hydroxy-1H-isochromen-1-one
• 英文别名: 8-hydroxyisochromen-1-one
• CAS: 4702-36-7
• 化学式: C₉H₆O₃
• 分子量: 162.145
• InChiKey: GZFXAOPNTDYZLP-UHFFFAOYSA-N

物化性质

• 沸点：
  342.7±42.0 °C(Predicted)
• 密度：
  1.403±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  8-hydroxy-1H-isochromen-1-one 、 环氧氯丙烷 生成 8-(Oxiran-2-ylmethoxy)isochromen-1-one
  参考文献：
  名称：

  KAVASAKI, XIROSI;BAN, MASATOSI;YAMAGUTI, TAKUDZI

  摘要：

  DOI：
• 作为产物：
  描述：

  2,6-二羟基苯甲酸 在 吡啶 、 4-二甲氨基吡啶 、 bis-triphenylphosphine-palladium(II) chloride 、 silver hexafluoroantimonate 、 copper(l) iodide 、 氯化亚砜 、 三苯基膦氯金 、 三乙胺 作用下， 以 1,4-二氧六环 、 乙二醇二甲醚 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 31.0h， 生成 8-hydroxy-1H-isochromen-1-one
  参考文献：
  名称：

  金（I）催化的8-羟基-3-取代的异香豆素的合成环化反应：内酯F的全合成

  摘要：

  高度区域选择性的金（I）催化2,2-二甲基-5-（炔基）-4 H-苯并[ d ] [1,3]二恶英-4-酮的6-内挖环化反应合成8描述了-羟基-3-取代的异香豆素。该反应的关键特征包括广泛的底物范围，可扩展性和对保护基的耐受性。这种新方法的合成实用性是由Exserolide F（一种含异香豆素的多元醇天然产物）的第一次全合成证明的。

  DOI：

  10.1021/acs.orglett.7b00673

文献信息

• Concise Synthesis of Isocoumarins through Rh-Catalyzed Direct Vinylene Annulation: Scope and Mechanistic Insight
  作者：Gen Mihara、Koushik Ghosh、Yuji Nishii、Masahiro Miura

  DOI：10.1021/acs.orglett.0c02112

  日期：2020.7.17

  subsequent C–C bond formation have emerged as powerful synthetic tools for the synthesis of elaborate cyclic molecules. In this report, we introduce an efficient synthetic method of 3,4-unsubstituted isocoumarins adopting an electron-deficient CpERh complex as the catalyst. The use of vinylene carbonate as a vinylene transfer reagent enables the direct construction of isocoumarins from readily available

  惰性C–H键的过渡金属催化活化和随后的C–C键形成已成为合成精细环状分子的有力合成工具。在本报告中，我们介绍了一种有效的合成方法，该方法采用缺电子的Cp E Rh络合物作为催化剂来合成3,4-未取代的异香豆素。碳酸亚乙烯酯作为亚乙烯基转移试剂的使用使得可以从容易获得的苯甲酸直接构建异香豆素，而无需任何外部氧化剂和碱。通过计算分析评估反应机理，以发现催化循环内前所未有的“铑转移”事件。
• JPH05317396A
  申请人：——

  公开号：JPH05317396A

  公开（公告）日：1993-12-03
• JPS58162586A
  申请人：——

  公开号：JPS58162586A

  公开（公告）日：1983-09-27
• Novel Quinoline Compound, and Composition Containing Centipede Extract or Compounds Isolated Therefrom for Prevention and Treatment of Cardiovascular Disease
  申请人：Park Ho Yong

  公开号：US20090247758A1

  公开（公告）日：2009-10-01

  The present invention relates to a composition for the prevention and treatment of cardiovascular diseases containing the novel quinoline compound, the centipede extracts or compounds isolated from the extracts. The novel quinoline compound, the centipede extracts or a quinoline compound and a phenol compound isolated from the extracts of the invention exhibit excellent LDL-antioxidant activity, ACAT inhibiting activity, and anti-inflammatory activities, so that they can be included as an effective ingredient in a composition for the prevention and treatment of cardiovascular disease including hyperlipidemia, atherosclerosis, coronary heart disease, and myocardial infarction mediated by LDL-oxidation, cholesteryl ester synthesis and accumulation, and inflammation.
• NOVEL QUINOLINE COMPOUND, AND COMPOSITION CONTAINING CENTIPEDE EXTRACT OR COMPOUNDS ISOLATED THEREFROM FOR PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASE
  申请人：PARK Ho Yong

  公开号：US20120220626A1

  公开（公告）日：2012-08-30

  The present invention relates to a composition for the prevention and treatment of cardiovascular diseases containing the novel quinoline compound, the centipede extracts or compounds isolated from the extracts. The novel quinoline compound, the centipede extracts or a quinoline compound and a phenol compound isolated from the extracts of the invention exhibit excellent LDL-antioxidant activity, ACAT inhibiting activity, and anti-inflammatory activities, so that they can be included as an effective ingredient in a composition for the prevention and treatment of cardiovascular disease including hyperlipidemia, atherosclerosis, coronary heart disease, and myocardial infarction mediated by LDL-oxidation, cholesteryl ester synthesis and accumulation, and inflammation.