γ-<(p-nitrophenyl)thio>propanol | 75032-30-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: γ-<(p-nitrophenyl)thio>propanol
• 英文别名: 3-(4-nitro-phenylsulfanyl)-propan-1-ol；(γ-Oxy-propyl)-(4-nitro-phenyl)-sulfid；3-(4-Nitro-phenylmercapto)-propan-1-ol；1-(3-hydroxypropylthio)-4-nitrobenzene；3-Hydroxypropylmercapto-4-nitrobenzol；3-(4-nitrophenyl)sulfanylpropan-1-ol
• CAS: 75032-30-3
• 化学式: C₉H₁₁NO₃S
• 分子量: 213.257
• InChiKey: XILUWJCKAFDLLU-UHFFFAOYSA-N

物化性质

• 熔点：
  41.5 °C
• 沸点：
  178 °C(Press: 0.2 Torr)
• 密度：
  1.30±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  91.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  γ-<(p-nitrophenyl)thio>propanol 生成 [3-hydroxypropyl-methyl-(4-nitrophenyl)-λ4-sulfanyl] perchlorate
  参考文献：
  名称：

  TADASHI IRIE; HIROSHI TANIDA, J. ORG. CHEM., 1980, 45, NO 24, 4961-4965

  摘要：

  DOI：
• 作为产物：
  描述：

  对硝基氯苯 在 sodium sulfide 、 氢氧化钾 、 乙醇 作用下， 生成 γ-<(p-nitrophenyl)thio>propanol
  参考文献：
  名称：

  Bennett; Berry, Journal of the Chemical Society, 1927, p. 1680

  摘要：

  DOI：

文献信息

• [EN] DERIVATIVES OF 4- (IMIDAZOL-5-YL)-2-(4-SULFOANILINO) PYRIMIDINE WITH CDK INHIBITORY ACTIVITY<br/>[FR] DERIVES DE 4- (IMIDAZOL-5-YL)-2-(4-SULFOANILINO) PYRIMIDINE A ACTIVITE INHIBITRICE CDK
  申请人：ASTRAZENECA AB

  公开号：WO2003076436A1

  公开（公告）日：2003-09-18

  Compounds of the formula (I): wherein R1, R2, R3, R4, R5 and p are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described are processes for their preparation and their use as medicaments, particularly medicaments for producing a cell cycle inhibitory (anti-cell-proliferation) effect in a warm-blooded animal, such as man.

  公式（I）的化合物：其中R1、R2、R3、R4、R5和p的定义如下，并且描述了药学上可接受的盐和体内可水解酯。还描述了它们的制备过程以及它们作为药物的用途，特别是作为用于在温血动物（如人）中产生细胞周期抑制（抗细胞增殖）效果的药物。
• Derivatives of 4-(imidazol-5-yl)-2-(4-sulfoanilino)pyrimidine with cdk inhibitory activity
  申请人：Newcombe John Nicholas

  公开号：US20050131000A1

  公开（公告）日：2005-06-16

  Compounds of the formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 and p are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described are processes for their preparation and their use as medicaments, particularly medicaments for producing a cell cycle inhibitory (anti-cell-proliferation) effect in a warm-blooded animal, such as man.

  本文描述了化学式（I）的化合物，其中R1、R2、R3、R4、R5和p的定义如本文中所述，并描述了其药物学上可接受的盐和体内可水解的酯。同时还描述了它们的制备过程以及它们作为药物的用途，特别是作为产生对温血动物（如人）的细胞周期抑制（抗细胞增殖）效应的药物。
• Derivatives of 4-(imidazol-5-yl)-2-(4-sulfoanilino)pyrimidine with CDK inhibitory activity
  申请人：AstraZeneca AB

  公开号：US07465728B2

  公开（公告）日：2008-12-16

  Compounds of the formula (I): wherein R1, R2, R3, R4, R5 and p are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described are processes for their preparation and their use as medicaments, particularly medicaments for producing a cell cycle inhibitory (anti-cell-proliferation) effect in a warm-blooded animal, such as man.

  本发明涉及式(I)的化合物，其中R1、R2、R3、R4、R5和p如定义所述，并描述了其药学上可接受的盐和体内可水解的酯。还描述了它们的制备过程以及它们作为药物的用途，特别是作为在温血动物（例如人）中产生细胞周期抑制（抗细胞增殖）效应的药物。
• Neighboring-group participation by hydroxyl oxygen in nucleophilic aromatic substitutions. Smiles rearrangements of (.omega.-hydroxyalkyl)methyl(p-nitrophenyl)sulfonium perchlorates in aqueous alkali
  作者：Tadashi Irie、Hiroshi Tanida

  DOI：10.1021/jo01312a028

  日期：1980.11
• FLOWERS W. T.; HOLT G.; OMOGBAI F.; POULOS C. P., J. CHEM. SOC. PERKIN TRANS, 1979, PART 1, NO 5, 1309-1312
  作者：FLOWERS W. T.、 HOLT G.、 OMOGBAI F.、 POULOS C. P.

  DOI：——

  日期：——