diethyl 6-(2,6-dimethylphenylamino)-1,4-dihydro-3-methyl-1-phenylpyrano[2,3-c]pyrazole-4,5-dicarboxylate | 1152427-60-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: diethyl 6-(2,6-dimethylphenylamino)-1,4-dihydro-3-methyl-1-phenylpyrano[2,3-c]pyrazole-4,5-dicarboxylate
• 英文别名: diethyl 6-(2,6-dimethylanilino)-3-methyl-1-phenyl-4H-pyrano[2,3-c]pyrazole-4,5-dicarboxylate
• CAS: 1152427-60-5
• 化学式: C₂₇H₂₉N₃O₅
• 分子量: 475.544
• InChiKey: MPIZOZUOBCWPNR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  35
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  91.7
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2,6-二甲基苯基异腈 、 依达拉奉 、 丁炔二酸二乙酯 以 乙腈 为溶剂， 反应 12.0h， 以76%的产率得到diethyl 6-(2,6-dimethylphenylamino)-1,4-dihydro-3-methyl-1-phenylpyrano[2,3-c]pyrazole-4,5-dicarboxylate
  参考文献：
  名称：

  Synthesis of fully substituted pyrano[2,3-c]pyrazole derivatives via a multicomponent reaction of isocyanides

  摘要：

  The three-component reaction of the zwitterions generated from dialkyl acetylenedicarboxylate and isocyanides with 3-methyl-1-phenyl-]H-pyrazol-5(4H)-one is described. The reaction afforded the corresponding special type of fully substituted pyrano[2,3-c]pyrazole derivatives in good yields without using any catalyst and activation. (C) 2009 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2009.02.035

文献信息

• Synthesis of fully substituted pyrano[2,3-c]pyrazole derivatives via a multicomponent reaction of isocyanides
  作者：Ahmad Shaabani、Afshin Sarvary、Ali Hossein Rezayan、Sajjad Keshipour

  DOI：10.1016/j.tet.2009.02.035

  日期：2009.4

  The three-component reaction of the zwitterions generated from dialkyl acetylenedicarboxylate and isocyanides with 3-methyl-1-phenyl-]H-pyrazol-5(4H)-one is described. The reaction afforded the corresponding special type of fully substituted pyrano[2,3-c]pyrazole derivatives in good yields without using any catalyst and activation. (C) 2009 Published by Elsevier Ltd.