12-(Tetrahydropyranyloxy)octadecanoic acid | 79967-16-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 12-(Tetrahydropyranyloxy)octadecanoic acid
• 英文别名: 12-O-tetrahydropyranylstearic acid；12-[(Oxan-2-yl)oxy]octadecanoic acid；12-(oxan-2-yloxy)octadecanoic acid
• CAS: 79967-16-1
• 化学式: C₂₃H₄₄O₄
• 分子量: 384.6
• InChiKey: JWOBFDOHCUOQSC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  27
• 可旋转键数：
  18
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  12-(Tetrahydropyranyloxy)octadecanoic acid 、 碘甲烷 在 cesium fluoride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以70%的产率得到Methyl 12-(tetrahydropyranyloxy)octadecanoate
  参考文献：
  名称：

  Cesium fluoride-promoted esterification of carboxylic acids. A practical alternative to the diazomethane method and direct conversion of organotin carboxylates

  摘要：

  DOI：

  10.1021/jo00033a048
• 作为产物：
  描述：

  (苯甲酰氧基)三丁基锡 在 sodium hydroxide 作用下， 生成 12-(Tetrahydropyranyloxy)octadecanoic acid
  参考文献：
  名称：

  Cesium fluoride-promoted esterification of carboxylic acids. A practical alternative to the diazomethane method and direct conversion of organotin carboxylates

  摘要：

  DOI：

  10.1021/jo00033a048

文献信息

• Use of esters or amides of hydroxylated carboxylic acids as solubilizers
  申请人：BASF Aktiengesellschaft

  公开号：US06365637B1

  公开（公告）日：2002-04-02

  The use of esters or amides of hydroxylated carboxylic acids as solubilizers, particularly for pharmaceutical, cosmetic and food preparations, is described.

  描述了羟基化羧酸酯或酰胺作为溶剂，特别是用于制药、化妆品和食品制剂的用途。
• LEAVE-ON NON-SOLID SKIN CONDITIONING COMPOSITIONS CONTAINING 12-[(12-HYDROXYOCTADECANOYL)OXY]OCTADECANOIC ACID
  申请人：Unilever PLC

  公开号：EP2637746A2

  公开（公告）日：2013-09-18
• LEAVE-ON NONSOLID SKIN CONDITIONING COMPOSITIONS CONTAINING 12-[(12-HYDROXYOCTADECANOYL)OXY] OCTADECANOIC ACID
  申请人：Madison Stephen Alan

  公开号：US20120122936A1

  公开（公告）日：2012-05-17

  Leave-on non-solid skin conditioning compositions containing 12-[(12-hydroxyoctadecanoyl)oxy]octadecanoic acid. 12[(12-hydroxyoctadecanoyl)oxy]octadecanoic acid can be easily incorporated in combination with lipophilic carriers that are liquid at room temperature. Compositions are able to deliver increased energy production by human fibroblasts. Preferred compositions also contain 12-hydroxy stearic acid and thus are able to deliver a wide range of skin benefits.
• US6365637B1
  申请人：——

  公开号：US6365637B1

  公开（公告）日：2002-04-02
• [EN] LEAVE-ON NON-SOLID SKIN CONDITIONING COMPOSITIONS CONTAINING 12-[(12-HYDROXYOCTADECANOYL)OXY] OCTADECANOIC ACID<br/>[FR] COMPOSITIONS REVITALISANTES NON SOLIDES À LAISSER SUR LA PEAU, CONTENANT DE L'ACIDE 12-[(12-HYDROXYOCTADÉCANOYL)OXY] OCTADÉCANOÏQUE
  申请人：UNILEVER PLC

  公开号：WO2012062554A2

  公开（公告）日：2012-05-18

  Leave-on non-solid skin conditioning compositions containing 12-[(12- hydroxyoctadecanoyl)oxy] octadecanoic acid. 12-[(12-hydroxyoctadecanoyl)oxy] octadecanoic acid can be easily incorporated in combination with lipophilic carriers that are liquid at room temperature. Compositions are able to deliver increased energy production by human fibroblasts. Preferred compositions also contain 12-hydroxystearic acid and thus are able to deliver a wide range of skin benefits.