N-phenyl-phthalamide | 16497-32-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-phenyl-phthalamide
• 英文别名: N-Phenyl-phthalamid；Phthalsaeure-amid-anilid；2-Phenylcarbamoyl-benzamid；n-Phenylphthalamide；2-N-phenylbenzene-1,2-dicarboxamide
• CAS: 16497-32-8
• 化学式: C₁₄H₁₂N₂O₂
• 分子量: 240.261
• InChiKey: BSJSDSDBMCEONS-UHFFFAOYSA-N

物化性质

• 沸点：
  361.7±25.0 °C(Predicted)
• 密度：
  1.284±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  72.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-丙-2-烯基苯甲酰胺 在 仲丁基锂 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 0.33h， 生成 N-phenyl-phthalamide
  参考文献：
  名称：

  Heteroatom-directed metalation. Lithiation of N-propenylbenzamides and N-propenyl-o-toluamides. Novel routes to ortho-substituted primary benzamide derivatives and N-unsubstituted isoquinolin-1(2H)-ones

  摘要：

  Reaction of N-propenylbenzamides 4 and 9, obtained by LDA-induced isomerization of the corresponding N-allylbenzamides 1, 8, and 14, with 2 equiv of sec-butyllithium or tert-butyllithium at low temperature regiospecifically generates the highly reactive N,ortho-dilithiated species (e.g., 5 and 17). These dilithio species react avidly with a wide spectrum of electrophilic reagents, including alkyl halides, giving adducts which on hydrolysis with warm 50% aqueous acetic acid are converted into ortho-substituted primary benzamides in excellent yields. Ortho-lithiation of N-propenylbenzamides is thus formally equivalent to ortho-lithiation of primary benzamides themselves. The utility of this important, previously unknown, synthetic operation is enhanced by the well-known facility with which the primary amide moiety can be transformed into other useful functional groups, as exemplified by the synthesis of 2-methoxy-6-methylbenzoic acid (12) and 2-methoxy-6-methylbenzonitrile (13) from N-propenyl-2-methoxybenzamide (9), N-Propenyl-o-toluamide (7) undergoes regiospecific dilithiation on nitrogen and on the methyl group under conditions analogous to those used for the N-propenylbenzamides. These dilithio species react with DMF or "Weinreb type" amides to give condensation products which cyclize to N-propenylisoquinolin-1(2H)-ones under midly acidic conditions. Removal of the N-propenyl moiety under more strongly acidic conditions provides N-unsubstituted isoquinolin-1(2H)-ones with high overall efficiency. This process is exemplified by the synthesis of isoquinolin-1(2H)-one (23) and its 3-n-butyl congener 26 from N-propenyl-2-methylbenzamide (7).

  DOI：

  10.1021/jo00035a030

文献信息

• 5-AMINOPYRIMIDINE DERIVATIVES AND USE THEREOF FOR COMBATING UNDESIRED PLANT GROWTH
  申请人：BAYER INTELLECTUAL PROPERTY GMBH

  公开号：US20150094205A1

  公开（公告）日：2015-04-02

  What is described are compounds of the general formula (I) and agrochemically acceptable salts thereof and their use in the field of crop protection.

  所描述的是一般式(I)的化合物及其农药可接受的盐，以及它们在作物保护领域的用途。
• Microparticles as ultrasonic contrast media
  申请人：DELINEATE

  公开号：EP1106187A2

  公开（公告）日：2001-06-13

  Ultrasonic contrast media are provided comprising small particles with entrapped gas, where the composition can be selected for rapid dissolution with production of microbubbles or maintaining the gas in microtubules, microchambers or microcracks, providing for echogenicity. The particles are readily formed by precipitation from a liquid, either solution or melt, of a monomeric material, followed by drying and mechanically reducing the size of the particles.

  超声波造影剂由夹带气体的小颗粒组成，其中的成分可以选择为快速溶解并产生微气泡，或将气体保持在微管、微腔或微裂缝中，以提供回声。从单体材料的液体（溶液或熔体）中析出，然后干燥并用机械方法减小颗粒的尺寸，就很容易形成颗粒。
• Cropping systems for managing weeds
  申请人：Monsanto Technology LLC

  公开号：EP2454940A2

  公开（公告）日：2012-05-23

  The invention provides cropping systems for managing weeds in crop environments. The cropping systems comprise, in one embodiment, transgenic plants that display tolerance to an auxin-like herbicide such as dicamba. Method for minimizing the development of herbicide resistant weeds are also provided.

  本发明提供了用于管理作物环境中杂草的种植系统。在一个实施方案中，该种植系统包括对诸如麦草畏之类的类助剂除草剂具有耐受性的转基因植物。本发明还提供了最大限度减少抗除草剂杂草发展的方法。
• Methods and compositions for PPO inhibitor tolerance in soybeans
  申请人：PIONEER HI-BRED INTERNATIONAL, INC.

  公开号：US10477789B2

  公开（公告）日：2019-11-19

  This invention relates generally to the detection of genetic differences among soybeans. More particularly, the invention relates to soybean quantitative trait loci (QTL) for tolerance to protoporphyrinogen oxidase inhibitors, to soybean plants possessing these QTLs, which map to a novel chromosomal region, and to genetic markers that are indicative of phenotypes associated with protoporphyrinogen oxidase inhibitor tolerance. Methods and compositions for use of these markers in genotyping of soybean and selection are also disclosed.

  本发明一般涉及大豆遗传差异的检测。更具体地说，本发明涉及对原卟啉原氧化酶抑制剂耐受性的大豆数量性状位点（QTL），涉及具有这些 QTL 的大豆植株（这些 QTL 映射到一个新的染色体区域），以及表明与原卟啉原氧化酶抑制剂耐受性相关表型的遗传标记。此外，还公开了在大豆基因分型和选择中使用这些标记的方法和组合。
• Method for treating post-emergent rice
  申请人：BASF SE

  公开号：US10694694B2

  公开（公告）日：2020-06-30

  The present disclosure provides a method for treating rice. The method comprises the steps of: providing a domestic rice crop plant and at least one ACCase-inhibiting aryloxyphenoxypropanoate herbicide selected from the group consisting of quizalofop or an ester thereof, haloxyfop, fluazifop or an ester thereof, clodinafop, clodinafop-propargyl, diclofop, and diclofop-methyl; applying an effective amount (measured in g AI/Ha) of the at least one aryloxyphenoxypropanoate herbicide to the domestic rice crop plant, post-emergence; thereby creating a treated rice plant; and growing the resulting treated rice plant.

  本公开提供了一种处理大米的方法。该方法包括以下步骤提供一种家用水稻作物植株和至少一种芳氧基苯氧基丙酸酯除草剂，该除草剂选自由喹唑啉草酯或其酯、氟唑草酯或其酯、氯氟吡氧乙酸、氯氟吡氧乙酸丙炔酯、双氯氟吡氧乙酸和甲基双氯氟吡氧乙酸组成的组；将有效量（以克 AI/Ha 计）的至少一种芳氧苯氧丙酸酯除草剂在萌发后施用到家稻作物植株上，从而形成经过处理的水稻植株；以及种植经过处理的水稻植株。