4-vinylpicolinonitrile | 100949-03-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-vinylpicolinonitrile
• 英文别名: 4-Vinyl-2-pyridinecarbonitrile；4-ethenylpyridine-2-carbonitrile
• CAS: 100949-03-9
• 化学式: C₈H₆N₂
• 分子量: 130.149
• InChiKey: VWBSHELHBHKBCF-UHFFFAOYSA-N

物化性质

• 沸点：
  260.5±28.0 °C(Predicted)
• 密度：
  1.07±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  36.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-vinylpicolinonitrile 在 盐酸 、 氯化亚砜 、 三乙胺 作用下， 以 四氢呋喃 、 乙醚 、 乙醇 、 二氯甲烷 为溶剂， 反应 7.33h， 生成 N-ethyl-N-{2-[2-(1-hydroxy-1-methylethyl)pyridin-4-yl]ethyl}-2-(2H-1,2,3-triazol-2-yl)benzamide
  参考文献：
  名称：

  [EN] HETEROARYL OREXIN RECEPTOR ANTAGONISTS
  [FR] COMPOSÉS HÉTÉROARYLE ANTAGONISTES DES RÉCEPTEURS DE L'OREXINE

  摘要：

  本发明涉及异芳基化合物，其为促进睡眠的受体拮抗剂。本发明还涉及所述化合物在潜在的治疗或预防神经和精神疾病中的用途，这些疾病中涉及促进睡眠的受体。本发明还涉及包含这些化合物的组合物。本发明还涉及这些组合物在潜在的预防或治疗涉及促进睡眠的受体的疾病中的用途。

  公开号：

  WO2016100156A1
• 作为产物：
  描述：

  4-氯-2-氰基吡啶 、 乙烯基硼酸频哪醇酯 在 四(三苯基膦)钯 、 sodium carbonate 作用下， 以 1,4-二氧六环 、 水 为溶剂， 生成 4-vinylpicolinonitrile
  参考文献：
  名称：

  [EN] HETEROARYL OREXIN RECEPTOR ANTAGONISTS
  [FR] COMPOSÉS HÉTÉROARYLE ANTAGONISTES DES RÉCEPTEURS DE L'OREXINE

  摘要：

  本发明涉及异芳基化合物，其为促进睡眠的受体拮抗剂。本发明还涉及所述化合物在潜在的治疗或预防神经和精神疾病中的用途，这些疾病中涉及促进睡眠的受体。本发明还涉及包含这些化合物的组合物。本发明还涉及这些组合物在潜在的预防或治疗涉及促进睡眠的受体的疾病中的用途。

  公开号：

  WO2016100156A1

文献信息

• SUBSTITUTED SYM-TRIINDOLE
  申请人：IHARA CHEMICAL INDUSTRY CO., LTD.

  公开号：EP1717239A1

  公开（公告）日：2006-11-02

  A novel substituted Sym-triindole derivative that is applicable to a wide spectrum of uses, such as various electrification preventions, electrification controls, capacitors, batteries, chemical sensors, displays, organic EL materials, solar cells, photodiodes, phototransistors, nonlinear materials, photorefractive materials, rustproof agents, adhesives, fibers, antistatic paints, electrodeposition paints, plating primers, electric corrosion protections and the like. There is provided a substituted Sym-triindole derivative of the general formula (1) (wherein R1, R2, R3 and R4 are each independently hydrogen, a halogen, a C1-C6 alkyl or the like, provided that, in no event, all of R1, R2, R3 and R4 are hydrogen simultaneously).

  一种新型取代的Sym-triindole衍生物，可广泛应用于各种电气化预防、电气化控制、电容器、电池、化学传感器、显示器、有机EL材料、太阳能电池、光电二极管、光电晶体管、非线性材料、光折射材料、防锈剂、粘合剂、纤维、抗静电涂料、电沉积涂料、电镀底漆、电腐蚀保护剂等。本发明提供了通式（1）的取代的苯并三吲哚衍生物 (其中 R1、R2、R3 和 R4 各自独立地为氢、卤素、C1-C6 烷基或类似物，但在任何情况下，R1、R2、R3 和 R4 都不能同时为氢）。
• Heteroaryl orexin receptor antagonists
  申请人：Merck Sharp & Dohme Corp.

  公开号：US10239838B2

  公开（公告）日：2019-03-26

  The present invention is directed to heteroaryl compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及杂芳基化合物，它们是奥曲肽受体的拮抗剂。本发明还涉及本文所述化合物在潜在治疗或预防涉及奥曲肽受体的神经和精神疾病中的用途。本发明还涉及包含这些化合物的组合物。本发明还涉及这些组合物在潜在预防或治疗涉及奥曲肽受体的此类疾病中的用途。
• Substituted sym-triindole
  申请人：Hiyoshi Hidetaka

  公开号：US20070191455A1

  公开（公告）日：2007-08-16

  A novel substituted Sym-triindole derivative that is applicable to a wide spectrum of uses, such as various electrification preventions, electrification controls, capacitors, batteries, chemical sensors, displays, organic EL materials, solar cells, photodiodes, phototransistors, nonlinear materials, photorefractive materials, rustproof agents, adhesives, fibers, antistatic paints, electrodeposition paints, plating primers, electric corrosion protections and the like. There is provided a substituted Sym-triindole derivative of the general formula (1) (wherein R 1 , R 2 , R 3 and R 4 are each independently hydrogen, a halogen, a C1-C6 alkyl or the like, provided that, in no event, all of R 1 , R 2 , R 3 and R 4 are hydrogen simultaneously).
• HETEROARYL OREXIN RECEPTOR ANTAGONISTS
  申请人：Kuduk Scott D.

  公开号：US20170260136A1

  公开（公告）日：2017-09-14

  The present invention is directed to heteroaryl compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.
• US4627859A
  申请人：——

  公开号：US4627859A

  公开（公告）日：1986-12-09