N-[2-[4-[(2-methylpropan-2-yl)oxy]phenyl]prop-2-enyl]aniline | 1313512-79-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-[2-[4-[(2-methylpropan-2-yl)oxy]phenyl]prop-2-enyl]aniline
• CAS: 1313512-79-6
• 化学式: C₁₉H₂₃NO
• 分子量: 281.398
• InChiKey: UMYMSDIETQPRPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  对叔丁氧基-Alpha-甲基苯乙烯 、 苯基羟胺 在 copper(l) chloride 、 copper dichloride 作用下， 以 1,2-二氯乙烷 为溶剂， 以88%的产率得到N-[2-[4-[(2-methylpropan-2-yl)oxy]phenyl]prop-2-enyl]aniline
  参考文献：
  名称：

  Cu(I)/Cu(II)-catalyzed allylic amination of alkenes

  摘要：

  Allylic hydrocarbons are selectively converted to the corresponding allyl amines in good to excellent yield by reaction with aryl hydroxylamines catalyzed by a 1:1 mixture of CuCl and CuCl(2) (10 mol %). Under these conditions unsymmetrical olefins react highly regioselectively with N-functionalization at the less substituted vinylic carbon. Trapping experiments indicate that a free nitrosoarene is not an intermediate in these reactions. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.04.119

文献信息

• Cu(I)/Cu(II)-catalyzed allylic amination of alkenes
  作者：Radhey S. Srivastava、Roy Bertrand、August A. Gallo、Kenneth M. Nicholas

  DOI：10.1016/j.tetlet.2011.04.119

  日期：2011.7

  Allylic hydrocarbons are selectively converted to the corresponding allyl amines in good to excellent yield by reaction with aryl hydroxylamines catalyzed by a 1:1 mixture of CuCl and CuCl(2) (10 mol %). Under these conditions unsymmetrical olefins react highly regioselectively with N-functionalization at the less substituted vinylic carbon. Trapping experiments indicate that a free nitrosoarene is not an intermediate in these reactions. (C) 2011 Elsevier Ltd. All rights reserved.