N-octadecyl-pyridin-2-ylmethyl-amine | 910232-13-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-octadecyl-pyridin-2-ylmethyl-amine
• 英文别名: octadecyl-pyridin-2-ylmethyl-amine；N-(pyridine-2-ylmethyl)octadecan-1-amine；N-(pyridin-2-ylmethyl)octadecan-1-amine
• CAS: 910232-13-2
• 化学式: C₂₄H₄₄N₂
• 分子量: 360.627
• InChiKey: FFXDRYQAMYZIER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.1
• 重原子数：
  26
• 可旋转键数：
  19
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-octadecyl-pyridin-2-ylmethyl-amine 、 copper(ll) bromide 以 甲醇 为溶剂， 生成 [(octadecyl-pyridin-2-ylmethyl-amine)2Cu(II)Br]Br
  参考文献：
  名称：

  含阳离子铜（II）的表面活性剂：分子结构，膜形态，以及对向列型液晶元的排列的影响。

  摘要：

  我们讨论了阳离子金属表面活性剂[（L Py14）2 Cu II ClO 4 ] ClO 4（1），[（L Py16）2 Cu II ClO 4 ] ClO 4（2），[（L Py18）2 Cu II ClO 4 ] ClO 4（3），[（L Py18）2 Cu II NO 3 ] NO 3（4），[（L Py18）2 Cu II Cl] Cl（5）和[（L Py18）2 Cu II Br] Br（6）通过用铜处理含有四，六或十八烷基链的合适的烷基胺甲基-2-吡啶配体来获得盐。这些金属表面活性剂在红外光谱带，具有同位素模式的光谱质量和元素组成之间显示出极好的一致性。可用于单晶X射线数据1，2，5和先前公布3揭示了在基面上结合到每个烷基胺甲基吡啶配体的胺和吡啶上的三角双锥体铜（II）离子和在顶端位置上结合了阴离子大肠菌素。除了具有最短十四烷基（C 14）链的表面活性剂外，这些物质还产生具有45–55

  DOI：

  10.1021/ic5004098
• 作为产物：
  描述：

  N-octadecyl-pyridin-2-ylmethylene-imine 在 sodium tetrahydroborate 作用下， 生成 N-octadecyl-pyridin-2-ylmethyl-amine
  参考文献：
  名称：

  含钌（II）的新型两亲物的电子，光取代，氧化还原和表面性质的研究

  摘要：

  报道了一系列具有吡啶和苯酚的含钌（II）的两亲物，其具有以下类型的双齿配体：[（L PyI）Ru II（bpy）2 ]（PF 6）2 （1），[[L PyA）Ru II（bpy）2 ]（PF 6）2 （2），[（L PhBuI）Ru II（bpy）2 ]（PF 6）（3）和[（L PhClI）Ru II（bpy）2 ]（PF 6）（4）。种类1和2是由治疗获得的[Ru（联吡啶）2氯2 ]与配体L PYI（ñ - （吡啶-2-基亚甲基）十八烷- 1-胺）和L PYA（ñ - （吡啶-2-基甲基）十八烷-1-胺）。亚胺种类3和4是通过[Ru（bpy）2（CF 3 SO 3）2 ]与胺配体HL PhBuA（2,4-二叔丁基-6-（（十八烷基氨基）甲基）苯酚）和HL PhClA（2,4-二氯-6-（（十八烷基氨基）甲基）苯酚）。化合物1− 4的特征在于电喷雾电离（ESI +）质谱，元素分析以及电化

  DOI：

  10.1021/ic1015934

文献信息

• Complexes with the fac-{M(CO)3}+ (M=99mTc, Re) moiety and long alkyl chain ligands as Lipiodol surrogates
  作者：Maung M. Saw、Philipp Kurz、Nikos Agorastos、T.S. Andy Hor、Felix X. Sundram、Yaw Kai Yan、Roger Alberto

  DOI：10.1016/j.ica.2006.04.023

  日期：2006.9

  186 Re and 99m Tc labeled Lipiodol surrogates expected to behave similarly. We have synthesized two bidentate and two tridentate ligands conjugated to a pendant C18 chain as well as their corresponding fac -[Re(CO) 3 ] + and fac -[Tc(CO) 3 ] + complexes. Three of the rhenium complexes have been structurally characterized. Labelling with [ 186 Re(OH 2 ) 3 (CO) 3 ] + and [ 99m Tc(OH 2 ) 3 (CO) 3 ] +

  在开发用于核医学中任何目的的新型标记化合物时，经常会观察到放射性药物在肝脏中的积累，通常代表着一个限制因素。旨在用放射性药物治疗肝癌，这种积累是期望的，但是化合物必须在延长的时间内保留在肝脏中，而不是随着时间的流逝而在整个体内被重新分配。已知碘油会保留在肝脏中，我们在这里进行一项研究，以制备预期表现相似的186 Re和99m Tc标记的碘油替代品。我们已经合成了两个C和C18侧链共轭的二齿和两个三齿配体，以及它们相应的fac-[Re（CO）3] +和fac-[Tc（CO）3] +配合物。三种complex配合物已经进行了结构表征。分别用[186 Re（OH 2）3（CO）3] +和[99m Tc（OH 2）3（CO）3] +标记，产率为90％。由于它们的亲脂性高，并且与脂质碘的主要成分具有紧密的结构关系，因此可以将其提取到脂质碘中。配合物在水中和在Lipiodol中稳定超过24小时。这些L
• On the Effect of Coordination and Protonation Preferences in the Amphiphilic Behavior of Metallosurfactants with Asymmetric Headgroups
  作者：Frank D. Lesh、Sarmad Sahiel Hindo、Mary Jane Heeg、Marco M. Allard、Prateek Jain、Bo Peng、Lew Hryhorczuk、Cláudio N. Verani

  DOI：10.1002/ejic.200800761

  日期：2009.1

  The metallosurfactants [NiII(LtBuODA)(OAc)] (1), [NiII(LtBuODA)2](2), [CuII(HLtBuODA)(LtBuODA)]ClO4·CH3OH (3), and [ZnII(HLtBuODA)2](ClO4)2 (4) where HLtBuODA = 2,4-di-tert-butyl-6-[(octadecyl(pyridin-2-ylmethyl)amino)methyl]phenol}were synthesized and characterized in an attempt to establish how coordination modes and protonation preferences relate to amphiphilic behavior. The archetypical compounds

  金属表面活性剂 [NiII(LtBuODA)(OAc)] (1)、[NiII(LtBuODA)2](2)、[CuII(HLtBuODA)(LtBuODA)]ClO4·CH3OH (3) 和 [ZnII(HLtBuODA)2] (ClO4)2 (4) 其中 HLtBuODA = 2,4-di-tert-butyl-6-[(octadecyl(pyridin-2-ylmethyl)amino)methyl]phenol}被合成并表征，试图确定如何配位模式和质子化偏好与两亲行为有关。原型化合物[NiIII(LtBuI)(OAc)]·CH3OH (5), [NiIII(LA)2]·CH3OH·H2O (6), [NiII(LtBuA)2]·2CH3OH (7), [CuII(HLtBuA) )(LtBuA)]ClO4 (8) 和 [ZnII(HLtBuA)(LtBuA)]ClO4 (9) 被合成以模拟蜡状金属表面活性剂
• Influence of the Apical Ligand in the Thermotropic Mesomorphism of Cationic Copper-Based Surfactants
  作者：Jeffery A. Driscoll、Paul H. Keyes、Mary Jane Heeg、Paul A. Heiney、Claudio N. Verani

  DOI：10.1021/ic8005162

  日期：2008.8.1

  A new pyridine-based bidentate ligand L-PyC18 was used to develop copper-containing surfactants that exhibit mesomorphism, Complexes [(L-PyC18)(2)(CuY)-Y-II]Y Were synthesized, where Y is an anionic ligand bromo (1), nitrato (2), or perchlorato (3). The nature of these apical ligands determines the mesogenic behavior of 1-3: The smallest bromo-substituted species 1 shows a metastable liquid crystalline phase at 110 degrees C, the nitrato-substituted 2 increases the transition temperature to 136 degrees C, and the bulky perchlorato-substituted 3 shows reversible mesophases at 153 degrees C. The behavior of these complexes shows similarities and suggests that at low temperatures the crystals of these compounds are bilayered structures with interdigitated alkyl tails. At higher temperatures the tails undergo rapid conformational changes that force these layers to swell until the opposing alkyl chains are separated from each other, and the mesophase is a monolayer smectic A. Small changes in the geometry of cationic mesogens can be imposed by the presence of apically coordinated anions, allowing for tuning in the properties of the resulting mesophases.
• DIRECT TO SUBSTRATE COATING VIA IN SITU POLYMERIZATION
  申请人：Henkel AG & Co. KGaA

  公开号：US20210309880A1

  公开（公告）日：2021-10-07

  Disclosed is a process that utilizes a modified Atom Transfer Radical Polymerization (ATRP) process to form a water-resistant coating in situ on a substrate. The process uses solvent soluble monomers, initiator and ligand to form a solvent insoluble water-resistant polymer coating that is deposited directly onto a metal trace on the substrate. The process is especially useful for providing a water-resistant coating to the circuits on a printed circuit board, wearable electronics, and biological sensors. The process can be run in an aqueous solvent in the open atmosphere and does not require a vacuum, heating steps or masking. The coating is deposited only on the metal trace and closely adjacent areas of the substrate.
• [EN] DIRECT TO SUBSTRATE COATING VIA IN SITU POLYMERIZATION<br/>[FR] REVÊTEMENT DIRECT SUR SUBSTRAT PAR POLYMÉRISATION IN SITU
  申请人：HENKEL AG & CO KGAA

  公开号：WO2020131445A1

  公开（公告）日：2020-06-25

  Disclosed is a process that utilizes a modified Atom Transfer Radical Polymerization (ATRP) process to form a water-resistant coating in situ on a substrate. The process uses solvent soluble monomers, initiator and ligand to form a solvent insoluble water-resistant polymer coating that is deposited directly onto a metal trace on the substrate. The process is especially useful for providing a water-resistant coating to the circuits on a printed circuit board, wearable electronics, and biological sensors. The process can be run in an aqueous solvent in the open atmosphere and does not require a vacuum, heating steps or masking. The coating is deposited only on the metal trace and closely adjacent areas of the substrate.