(E)-1-(2-((4-methoxyphenyl)sulfonyl)vinyl)-2-chlorobenzene | 76859-80-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-1-(2-((4-methoxyphenyl)sulfonyl)vinyl)-2-chlorobenzene
• 英文别名: 1-chloro-2-[(E)-2-(4-methoxyphenyl)sulfonylethenyl]benzene
• CAS: 76859-80-8
• 化学式: C₁₅H₁₃ClO₃S
• 分子量: 308.785
• InChiKey: PEURWUXNBLDSQR-ZHACJKMWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  三甲基碘化锍 、 (E)-1-(2-((4-methoxyphenyl)sulfonyl)vinyl)-2-chlorobenzene 在 potassium tert-butylate 作用下， 以 二甲基亚砜 为溶剂， 反应 1.0h， 以76.4%的产率得到
  参考文献：
  名称：

  Reddy, D. Bhaskar; Sankaraiah, B.; Balaji, T., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1980, vol. 19, # 7, p. 563 - 566

  摘要：

  DOI：
• 作为产物：
  描述：

  4-甲氧基-苯磺酸钠 在 sodium hydroxide 、 苄胺 作用下， 以 水 、 溶剂黄146 为溶剂， 反应 2.0h， 生成 (E)-1-(2-((4-methoxyphenyl)sulfonyl)vinyl)-2-chlorobenzene
  参考文献：
  名称：

  Reddy, Bhaskar D.; Sankaraiah, B.; Balaji, T., Phosphorus and Sulfur and the Related Elements, 1983, vol. 16, p. 293 - 298

  摘要：

  DOI：

文献信息

• Discovery of Vinyl Sulfones as a Novel Class of Neuroprotective Agents toward Parkinson’s Disease Therapy
  作者：Seo Yeon Woo、Ji Hyun Kim、Mi Kyeong Moon、Se-Hee Han、Seul Ki Yeon、Ji Won Choi、Bo Ko Jang、Hyo Jung Song、Yong Gu Kang、Jin Woo Kim、Jaeick Lee、Dong Jin Kim、Onyou Hwang、Ki Duk Park

  DOI：10.1021/jm401788m

  日期：2014.2.27

  Although the etiology of Parkinson's disease (PD) remains elusive, recent studies suggest that oxidative stress contributes to the cascade leading to dopaminergic (DAergic) neurodegeneration. The Nrf2, signaling is the main pathway responsible for cellular defense system against oxidative stress. Nrf2 is a transcription factor that regulates environmental stress response by inducing expression of antioxidant enzyme genes. We have synthesized novel vinyl sulfone derivatives. They exhibited a broad range of activities in inducing HO-1, whose gene expression is under the control of Nrf2. Among them, compound 12g was confirmed to activate Nrf2 and induce expression of the Nrf2-dependent antioxidant enzymes NQO1, GCLC, GLCM, and HO-1, at both mRNA and protein levels in DAergic neuronal cells. This was accompanied by protection of DAergic neurons in both in vitro and MPTP-induced in vivo models of PD. In addition, compound 12g effectively resulted in attenuation of the PD-associated behavioral deficits in the mouse model.
• Reddy, Bhaskar D.; Sankaraiah, B.; Balaji, T., Phosphorus and Sulfur and the Related Elements, 1983, vol. 16, p. 293 - 298
  作者：Reddy, Bhaskar D.、Sankaraiah, B.、Balaji, T.

  DOI：——

  日期：——
• Reddy, D. Bhaskar; Sankaraiah, B.; Balaji, T., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1980, vol. 19, # 7, p. 563 - 566
  作者：Reddy, D. Bhaskar、Sankaraiah, B.、Balaji, T.

  DOI：——

  日期：——