α-Aethyl-octansaeureaethylester | 25234-26-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: α-Aethyl-octansaeureaethylester
• 英文别名: 2-Ethyl-octansaeure-ethylester；2-ethyl-octanoic acid ethyl ester；2-Aethyl-octansaeure-aethylester；Octanoic acid, 2-ethyl-, ethyl ester；ethyl 2-ethyloctanoate
• CAS: 25234-26-8
• 化学式: C₁₂H₂₄O₂
• 分子量: 200.321
• InChiKey: ANRXOJOPPWWPFQ-UHFFFAOYSA-N

物化性质

• 沸点：
  135 °C(Press: 36 Torr)
• 密度：
  0.862 g/cm3(Temp: 25 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  三乙基硼 、 2-溴辛酸乙酯 在 potassium tert-butylate 作用下， 以 四氢呋喃 、 叔丁醇 为溶剂， 生成 α-Aethyl-octansaeureaethylester
  参考文献：
  名称：

  Mono- and dialkylation of ethyl dihaloacetates by reaction with organoboranes under the influence of potassium tert-butoxide. Convenient procedures for the conversion of olefins into the .alpha.-halo alkanoic or dialkylacetic acid esters via hydroboration

  摘要：

  DOI：

  10.1021/ja01009a048

文献信息

• FIVE-MEMBERED HETEROCYCLIC COMPOUNDS
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP1541564A1

  公开（公告）日：2005-06-15

  The present invention provides a compound represented by the formula: wherein R1 is an optionally substituted 5-membered heterocyclic group; X, Y and V are the same or different and each is a bond, an oxygen atom, a sulfur atom and the like; Q is a divalent hydrocarbon group having 1 to 20 carbon atoms; ring A is an aromatic ring optionally further having 1 to 3 substituents; Z is -(CH2)n-Z1- or -Z1-(CH2)n- (n is an integer of 0 to 8, Z1 is a bond, an oxygen atom, a sulfur atom and the like); ring B is a nitrogen-containing heterocycle optionally further having 1 to 3 substituents; W is a bond or a divalent hydrocarbon group having 1 to 20 carbon atoms; R2 is a hydrogen atom, a cyano group, -PO(OR9)(OR10) (R9 and R10 are the same or different and each is a hydrogen atom or an optionally substituted hydrocarbon group, and R9 and R10 are optionally bonded to form an optionally substituted ring) and the like, or a salt thereof, which has a superior adipose tissue weight decreasing action, a hypoglycemic action and a hypolipidemic action, and which is useful as an agent for the prophylaxis or treatment of obesity, diabetes mellitus, hyperlipidemia, impaired glucose tolerance, hypertension and the like.

  本发明提供了一种由以下式表示的化合物： 其中R1是可选择地取代的5-成员杂环基团；X、Y和V相同或不同，每个都是键，氧原子，硫原子等；Q是具有1到20个碳原子的二价碳氢基团；环A是一个芳香环，可选择地进一步具有1到3个取代基；Z是-(CH2)n-Z1-或-Z1-( )n-（n是0到8的整数，Z1是键，氧原子，硫原子等）；环B是一个含氮杂环，可选择地进一步具有1到3个取代基；W是键或具有1到20个碳原子的二价碳氢基团；R2是氢原子，氰基，-PO(OR9)(OR10)（R9和R10相同或不同，每个是氢原子或可选择地取代的碳氢基团，R9和R10可选择地结合形成可选择地取代的环）等，或其盐，具有优越的减少脂肪组织重量的作用，降糖作用和降脂作用，并且作为预防或治疗肥胖症，糖尿病，高脂血症，糖耐量受损，高血压等的药剂是有用的。
• Five-membered heterocyclic compounds
  申请人：Momose Yu

  公开号：US20060135578A1

  公开（公告）日：2006-06-22

  The present invention provides a compound represented by the formula: wherein R 1 is an optionally substituted 5-membered heterocyclic group; X, Y and V are the same or different and each is a bond, an oxygen atom, a sulfur atom and the like; Q is a divalent hydrocarbon group having 1 to 20 carbon atoms; ring A is an aromatic ring optionally further having 1 to 3 substituents; Z is —(CH 2 ) n -Z 1 - or -Z 1 -(CH 2 ) n — (n is an integer of 0 to 8, Z 1 is a bond, an oxygen atom, a sulfur atom and the like); ring B is a nitrogen-containing heterocycle optionally further having 1 to 3 substituents; W is a bond or a divalent hydrocarbon group having 1 to 20 carbon atoms; R 2 is a hydrogen atom, a cyano group, —PO(OR 9 )(OR 10 ) (R 9 and R 10 are the same or different and each is a hydrogen atom or an optionally substituted hydrocarbon group, and R 9 and R 10 are optionally bonded to form an optionally substituted ring) and the like, or a salt thereof, which has a superior adipose tissue weight decreasing action, a hypoglycemic action and a hypolipidemic action, and which is useful as an agent for the prophylaxis or treatment of obesity, diabetes mellitus, hyperlipidemia, impaired glucose tolerance, hypertension and the like.

  本发明提供一种化合物，其化学式表示为：其中，R1为可选取的取代的5-成员杂环基；X、Y和V相同或不同，每个都是键，氧原子，硫原子等；Q为具有1到20个碳原子的二价碳氢基团；环A为芳香环，可选地进一步具有1到3个取代基；Z为—(CH2)n-Z1-或-Z1-( )n—（n为0到8的整数，Z1为键，氧原子，硫原子等）；环B为含氮杂环，可选地进一步具有1到3个取代基；W为键或具有1到20个碳原子的二价碳氢基团；R2为氢原子，氰基，—PO(OR9)(OR10)（R9和R10相同或不同，每个都是氢原子或可选取的取代的碳氢基团，R9和R10可选择性地结合形成可选取的取代环）等，或其盐，具有优异的减轻脂肪组织重量、降血糖和降血脂作用，可用作预防或治疗肥胖症、糖尿病、高脂血症、糖耐量受损、高血压等的药剂。
• Carbamates of 4-hydroxyanisole as prodrugs for chemotherapy of melanoma
  申请人：Merck & Co., Inc.

  公开号：EP0296811A2

  公开（公告）日：1988-12-28

  Derivatives of 4-hydroxyanisole carbamate are suitable as prodrugs for the delivery and concentration of 4-hydroxyanisole in melanomas.

  4-hydroxyanisole carbamate 的衍生物适合作为原药，用于在黑色素瘤中输送和浓缩 4-hydroxyanisole 。
• Pflaster zur transdermalen Anwendung
  申请人：KNOLL AG

  公开号：EP0380989A2

  公开（公告）日：1990-08-08

  Pflaster zur transdermalen Anwendung mindestens eines systemisch wirksamen pharmazeutischen Wirkstoffs mit einem Molekulargewicht unter 1000, das zusätzlich zum Wirkstoff und üblichen galenischen Hilfsmitteln Dexpanthenol als Penetrationshilfsmittel enthält.

  用于透皮涂抹至少一种分子量小于 1000 的系统活性药物成分的膏药，除活性成分和常规半乳状辅料外，还含有作为渗透助剂的脱泛醇。
• Fluorosurfactant-containing ink compositions for inkjet printing
  申请人：Kateeva, Inc.

  公开号：US10093819B2

  公开（公告）日：2018-10-09

  Ink compositions formulated for inkjet printing the hole injecting layer (HIL) or hole transporting layer (HTL) of an organic light emitting diode (OLED) are provided. The ink compositions comprise fluorosurfactants that prevent uncontrolled spreading of the printed ink compositions. Also provided are methods of inkjet printing the HILs or HTLs using the ink compositions.

  提供了用于喷墨打印有机发光二极管（OLED）的孔注入层（HIL）或孔传输层（HTL）的墨水组合物。这些墨水组合物包含含氟表面活性剂，可防止打印墨水组合物失控扩散。此外，还提供了使用墨水组合物喷墨打印 HIL 或 HTL 的方法。