4-biphenyl-4-yl-pyrimidine | 92867-89-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-biphenyl-4-yl-pyrimidine
• 英文别名: 4-(biphenyl-4-yl)pyrimidine；4-(4-Pyrimidyl)-diphenyl；4-(4-Phenylphenyl)pyrimidine
• CAS: 92867-89-5
• 化学式: C₁₆H₁₂N₂
• 分子量: 232.285
• InChiKey: QAHGDOUMCYILBM-UHFFFAOYSA-N

物化性质

• 溶解度：
  <0.2 [ug/mL]

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  溴甲苯 、 4-biphenyl-4-yl-pyrimidine 以 丙酮 为溶剂， 以94 %的产率得到4-([1,1'-biphenyl]-4-yl)-1-benzylpyrimidin-1-ium bromide
  参考文献：
  名称：

  间歇和流动下铱催化嘧啶鎓盐的不对称完全氢化

  摘要：

  本研究提出了一种使用 Ir/(S,S)-f-Binaphane 络合物作为催化剂来完全氢化嘧啶鎓盐的高度对映选择性方法。这种方法可以轻松获得一系列完全饱和的手性六氢嘧啶，它们在许多生物活性分子中普遍存在。该反应在温和的反应条件下无需添加剂即可表现出高产率和对映选择性。这种方法以连续流方式的成功应用进一步拓宽了其实用性。

  DOI：

  10.1039/d3gc04364a
• 作为产物：
  描述：

  1,3,5-三嗪 、 联苯单乙酮 在 吗啉 、 三乙胺 作用下， 以 甲醇 为溶剂， 反应 72.0h， 以85%的产率得到4-biphenyl-4-yl-pyrimidine
  参考文献：
  名称：

  Direct access to pyrimidines through organocatalytic inverse-electron-demand Diels–Alder reaction of ketones with 1,3,5-triazine

  摘要：

  已开发了一种通过烯胺催化的酮与1,3,5-三嗪之间的有机催化反向电子需求Diels-Alder反应。

  DOI：

  10.1039/c5ra16995j

文献信息

• Metal coordination compound, luminescence device and display apparatus
  申请人：——

  公开号：US20030068536A1

  公开（公告）日：2003-04-10

  An electroluminescence device having a layer containing a specific metal coordination compound is provided. The metal coordination compound is represented by formula (1) below: ML m L′ n (1), wherein M is a metal atom of Ir, Pt, Rh or Pd; L and L′ are mutually different bidentate ligands; m is 1, 2 or 3 and n is 0, 1 or 2 with the proviso that m+n is 2 or 3; a partial structure MLm is represented by formula (2) shown below and a partial structure ML′ n is represented by formula (3) or (4) shown below: 1 The metal coordination compound of the formula (1) is characterized by having at least one aromatic substituent for at least one of CyN1, CyN2, CyC1 and CyC2. The metal coordination compound having the aromatic substituent is effective in providing high-efficiency luminescence, long-term high luminance, and less deterioration by current passing.

  提供了一种含有特定金属配位化合物层的电致发光器件。该金属配位化合物由下式（1）表示：MLmL′n(1)，其中M为Ir、Pt、Rh或Pd的金属原子；L和L'为不同的双齿配体；m为1、2或3，n为0、1或2，但m+n为2或3；部分结构MLm由下式（2）表示，部分结构ML'n由下式（3）或（4）表示：1式（1）中的金属配位化合物的特征是至少在CyN1、CyN2、CyC1和CyC2中的至少一个上具有芳香基取代。具有芳香基取代的金属配位化合物能够有效提供高效率发光、长期高亮度和通过电流的少量退化。
• Fluorine-substituted-4-alkenylbenzoic acid and derivatives thereof, and nematic liquid crystal composition containing cyanophenyl benzoate derivatives and liquid crystal display system using the same
  申请人：DAINIPPON INK AND CHEMICALS, INC.

  公开号：US20020053659A1

  公开（公告）日：2002-05-09

  A novel liquid crystal compound, a nematic liquid crystal composition, and a liquid crystal display system using the composition are disclosed herein. The liquid crystal compound is represented by the general formula (I): 1 wherein R represents a hydrogen atom or a straight chain alkyl group having 1 to 7 carbon atoms and each of X, Y and Z independently represents hydrogen atom or fluorine atom. The nematic liquid crystal composition of the present invention can provide liquid crystal materials in response to desired purposes even by its addition in a small amount without spoiling other characteristics.

  本文公开了一种新型液晶化合物、一种向列相液晶组合物和使用该组合物的液晶显示系统。该液晶化合物由通式(I)表示：其中，R代表氢原子或1至7个碳原子的直链烷基，X、Y和Z各自独立地表示氢原子或氟原子。本发明的向列相液晶组合物可以在添加少量的情况下，响应所需的目的提供液晶材料，而不破坏其他特性。
• Naphthalene derivative and liquid crystal composition comprising the same
  申请人：Dainippon Ink and Chemicals, Inc.

  公开号：US20030136944A1

  公开（公告）日：2003-07-24

  Disclosed in a novel liquid-crystalline compound which is a naphthalene derivative useful as an electro-optical liquid crystal display material, a liquid crystal composition containing such naphthalene derivatives and a liquid crystal display device comprising the same. The naphthalene derivative provided by the present invention exhibits an excellent liquid-crystallinity and miscibility with currently widely used liquid crystal compositions or compositions. The addition of the naphthalene derivative makes it possible to drastically lower the threshold voltage of the liquid crystal composition while maintaining its high response. The naphthalene derivative of the present invention is characterized by a large birefringence index. Further, most of the naphthalene derivative of the present invention has no strongly polar group in its molecule and thus can also be used for active matrix driving. Moreover, as shown in the foregoing examples, the naphthalene derivative of the present invention can be easily produced and is colorless and chemically stable. Accordingly, the liquid crystal composition comprising the naphthalene derivative of the present invention is extremely useful as a practical liquid crystal composition, particularly a liquid crystal composition which can operate within a wide temperature range and requires a high speed response and a low voltage driving.

  本发明揭示了一种新型液晶化合物，该化合物是萘衍生物，可用作电光液晶显示材料，液晶组合物包含这种萘衍生物，以及包含它的液晶显示装置。本发明提供的萘衍生物表现出优异的液晶性和与目前广泛使用的液晶组合物或配方的混溶性。添加萘衍生物可以在保持高响应的同时大幅降低液晶组合物的阈值电压。本发明的萘衍生物具有较大的双折射率指数。此外，大多数本发明的萘衍生物分子中没有强极性基团，因此也可用于有源矩阵驱动。此外，正如前面的例子所示，本发明的萘衍生物可以很容易地制备，无色且化学稳定。因此，包含本发明的萘衍生物的液晶组合物非常有用作为实用的液晶组合物，特别是需要在广泛的温度范围内工作并需要高速响应和低电压驱动的液晶组合物。
• New utilities of tricyclic compounds
  申请人：Ishizuka Natsuki

  公开号：US20080318958A1

  公开（公告）日：2008-12-25

  Pharmaceutical compositions for enhancing the expression of apoAI are provided, which are used as medicaments for treatment of cardiovascular diseases on the basis of improving the functions of HDL. Pharmaceutical compositions for enhancing the expression of apoAI which comprises a compound of formula (I): in which X 1 and X 1 are independently an aryl or heteroaryl that may be optionally substituted, a hydrogen, a halogen, or the like; ring A is a benzene ring or 6-membered aromatic heterocyclic ring containing 1 to 3 N atoms that may be optionally condensed with another aromatic ring; R 1 to R 4 are independently a hydrogen, a halogen, a lower alkyl, a lower alkoxy or the like; a prodrug thereof, a pharmaceutically acceptable salt or solvate of them are disclosed.

  提供用于增强apoAI表达的药物组合物，用于改善HDL功能，作为治疗心血管疾病的药物。药物组合物用于增强apoAI表达，其中包括式(I)的化合物：其中X1和X2独立地是芳基或杂芳基，可以选择性地被取代，氢，卤素等；环A是苯环或含有1至3个N原子的6元芳杂环，可以选择性地与另一个芳香环融合；R1至R4独立地是氢，卤素，低碳基，低碳氧基或类似物；其前药，药学上可接受的盐或溶剂也被披露。
• Fluorine-substituted 4-alkenylbenzoic acid and derivatives thereof, and nematic liquid crystal composition containing cyanophenyl benzoate derivatives and liquid crystal display system using the same
  申请人：DAINIPPON INK AND CHEMICALS, INC.

  公开号：EP0919536A1

  公开（公告）日：1999-06-02

  A novel liquid crystal compound, a nematic liquid crystal composition, and a liquid crystal display system using the composition are disclosed herein. The liquid crystal compound is represented by the general formula (I): wherein R represents a hydrogen atom or a straight chain alkyl group having 1 to 7 carbon atoms and each of X, Y and Z independently represents hydrogen atom or fluorine atom. The nematic liquid crystal composition of the present invention can provide liquid crystal materials in response to desired purposes even by its addition in a small amount without spoiling other characteristics.

  本文公开了一种新型液晶化合物、向列液晶组合物以及使用该组合物的液晶显示系统。该液晶化合物由通式 (I) 表示： 其中 R 代表氢原子或具有 1 至 7 个碳原子的直链烷基，X、Y 和 Z 各自独立地代表氢原子或氟原子。本发明的向列液晶组合物即使添加量很小，也能提供符合所需目的的液晶材料，而不会破坏其他特性。