4-chloro-6-(cyclohexyloxy)pyrimidine | 405931-43-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-chloro-6-(cyclohexyloxy)pyrimidine
• 英文别名: 4-chloro-6-cyclohexyloxypyrimidine
• CAS: 405931-43-3
• 化学式: C₁₀H₁₃ClN₂O
• 分子量: 212.679
• InChiKey: RZESALIAYGLOID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  35
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(4-(4-amino-1H-pyrazole-3-carboxamido)phenyl)piperazine-1-carboxylic acid tert-butyl ester 、 4-chloro-6-(cyclohexyloxy)pyrimidine 在 溶剂黄146 作用下， 以 水 为溶剂， 生成
  参考文献：
  名称：

  Rational design of 4-((6-phenoxypyrimidin-4-yl)amino)-N-(4-(piperazin-1-yl)phenyl)-1H-pyrazole-3-carboxamide (LT-540-717) as orally bioavailable FLT3 inhibitor

  摘要：

  we describe the discovery of compound LT-540-717 (32), a potent FLT3 inhibitor (IC50: 0.62 nM), starting from FN-1501. Compound 32 exhibited highly inhibitory activity against several acquired FLT3 mutations including FLT3 (ITD, D835V), FLT3 (ITD, F691L), FLT3 (D835Y) and FLT3 (D835V). Additionally, 32 displayed potent antiproliferative activity against FLT3-mutation driven BaF3 and AML cells. Oral administration

  DOI：

  10.1016/j.ejmech.2023.115448
• 作为产物：
  描述：

  4,6-二氯嘧啶 、 环己醇 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 以78 %的产率得到4-chloro-6-(cyclohexyloxy)pyrimidine
  参考文献：
  名称：

  Rational design of 4-((6-phenoxypyrimidin-4-yl)amino)-N-(4-(piperazin-1-yl)phenyl)-1H-pyrazole-3-carboxamide (LT-540-717) as orally bioavailable FLT3 inhibitor

  摘要：

  we describe the discovery of compound LT-540-717 (32), a potent FLT3 inhibitor (IC50: 0.62 nM), starting from FN-1501. Compound 32 exhibited highly inhibitory activity against several acquired FLT3 mutations including FLT3 (ITD, D835V), FLT3 (ITD, F691L), FLT3 (D835Y) and FLT3 (D835V). Additionally, 32 displayed potent antiproliferative activity against FLT3-mutation driven BaF3 and AML cells. Oral administration

  DOI：

  10.1016/j.ejmech.2023.115448

文献信息

• Pyrimidine compounds and their use
  申请人：——

  公开号：US20040077669A1

  公开（公告）日：2004-04-22

  Pyrimidine compounds of formula (1): 1 wherein R 1 is C 3 -C 7 alkynyl optionally substituted with halogen; R 2 and R 3 are independently hydrogen or the like; and R 4 is C 3 -C 7 alkynyloxy optionally substituted with halogen, optionally substituted phenyl, or the like have an excellent pesticidal effect.

  公式（1）的嘧啶化合物：1其中R1是C3-C7炔基，可选地取代卤素; R2和R3分别是氢或类似物; R4是C3-C7炔氧基，可选地取代卤素，可选地取代苯基或类似物，具有优异的杀虫效果。
• PYRIMIDINE COMPOUNDS AND THEIR USE
  申请人：SUMITOMO CHEMICAL COMPANY LIMITED

  公开号：EP1366026A2

  公开（公告）日：2003-12-03
• PYRIMIDINE COMPOUNDS AND THEIR USE AS PESTICIDES
  申请人：SUMITOMO CHEMICAL COMPANY LIMITED

  公开号：EP1366026B1

  公开（公告）日：2004-12-01
• US7291730B2
  申请人：——

  公开号：US7291730B2

  公开（公告）日：2007-11-06
• [EN] PYRIMIDINE COMPOUNDS AND THEIR USE<br/>[FR] COMPOSES PYRIMIDIQUES ET LEUR UTILISATION
  申请人：SUMITOMO CHEMICAL CO

  公开号：WO2002024663A2

  公开（公告）日：2002-03-28

  Pyrimidine compounds of formula (1), wherein R1 is C3-C7 alkynyl optionally substituted with halogen; R?2 and R3¿ are independently hydrogen or the like; and R4 is C3-C7 alkynyloxy optionally substituted with halogen, optionally substituted phenyl, or the like have an excellent pesticidal effect.