3-(4-chlorophenyl)-5-cyanomethyl-1-phenylpyrazole | 153391-35-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(4-chlorophenyl)-5-cyanomethyl-1-phenylpyrazole
• 英文别名: 2-[5-(4-Chlorophenyl)-2-phenylpyrazol-3-yl]acetonitrile
• CAS: 153391-35-6
• 化学式: C₁₇H₁₂ClN₃
• 分子量: 293.755
• InChiKey: CTWKRMCPHTWRIP-UHFFFAOYSA-N

物化性质

• 沸点：
  480.0±35.0 °C(Predicted)
• 密度：
  1.21±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  41.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(4-chlorophenyl)-5-cyanomethyl-1-phenylpyrazole 在 盐酸 作用下， 反应 4.0h， 以65%的产率得到<3-(4-chlorophenyl)-1-phenylpyrazol-5-yl>acetic acid
  参考文献：
  名称：

  Ram, Vishnu Ji; Haque, Navedul; Singh, Sanjay Kumar, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1993, vol. 32, # 9, p. 924 - 928

  摘要：

  DOI：
• 作为产物：
  描述：

  苯肼,盐酸盐 、 6-(4-chlorophenyl)-3-cyano-4-methylsulfanyl-2H-pyran-2-one 在 吡啶 作用下， 以 甲醇 为溶剂， 反应 6.0h， 以46%的产率得到3-(4-chlorophenyl)-5-cyanomethyl-1-phenylpyrazole
  参考文献：
  名称：

  Synthesis of E - and Z -Pyrazolylacrylonitriles and their evaluation as novel antioxidants

  摘要：

  A facile synthesis of (Z)- and (E)-2-(5-arylpyrazol-3-yl)-3-(pyrrol-2-yl)acrylonitriles and (Z)-2-(1,3-diarylpyrazol-5-yl)-3-(pyrrol-2-yl)acrylonitriles, and isomerisation of (Z)-2-(5-arylpyrazolyl)acrylonitriles to (E)-2-(5-arylpyrazolyl)acrylonitriles under basic conditions have been reported. (Z)-2-(1,3-Diarylpyrazolyl)acrylonitrile did not undergo isomerisation under the similar conditions. New compounds were identified on the basis of their spectral data (H-1-, C-13-, H-1-H-1 COSY, NOESY, NOE, HMQC NMR, IR, UV and EI mass). The structures of one acrylonitrile and five of their precursor 6-arylpyran-2-ones and cyanomethylpyrazoles were confirmed by X-ray crystallographic studies. Effects of pyrazolylacrylonitriles and their precursors on rat liver-microsomal lipid peroxidation were evaluated in vitro with a view to establish structure-activity relationship and to identify a lead compound. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(99)00056-5

文献信息

• Synthesis, characterization and in vitro anti-invasive activity screening of polyphenolic and heterocyclic compounds
  作者：Virinder S Parmar、Nawal K Sharma、Mofazzal Husain、Arthur C Watterson、Jayant Kumar、Lynne A Samuelson、Ashok L Cholli、Ashok K Prasad、Ajay Kumar、Sanjay Malhotra、Naresh Kumar、Amitabh Jha、Amarjit Singh、Ishwar Singh、Himanshu、Archana Vats、Najam A Shakil、Smriti Trikha、Shubasish Mukherjee、Sunil K Sharma、Sanjay K Singh、Ajay Kumar、Hriday N Jha、Carl E Olsen、Christophe P Stove、Marc E Bracke、Marc M Mareel

  DOI：10.1016/s0968-0896(02)00539-4

  日期：2003.3

  embryonic chick heart fragments in vitro. Three of them (a pyrazole derivative, an isoxazolylcoumarin and a prenylated desoxybenzoin) inhibited invasion at concentrations as low as 1 microM; instead of occupying and replacing the heart tissue within 8 days, the MCF-7/6 cells grew around the heart fragments and left it intact, when treated with these compounds. At the anti-invasive concentration of 1 microM

  侵袭是恶性肿瘤的标志，是未经治疗的癌症患者预后不良的原因。寻找抗侵入治疗方法使我们在侵入试验中筛选了不同类别的化合物以了解其作用。在本研究中合成了39种新化合物以及56种已经报告的化合物，这些化合物主要属于内酯，吡唑，异恶唑，香豆素，脱氧安息香酮，芳香族酮，查耳酮，苯并二氢吡喃，异黄酮类化合物，已针对侵袭性人类的器官典型培养进行了测试MCF-7 / 6乳腺癌细胞体外具有胚胎鸡心碎片。其中的三种（吡唑衍生物，异恶唑基香豆素和烯丙基化的脱氧安息香）可在低至1 microM的浓度下抑制入侵。用这些化合物处理后，MCF-7 / 6细胞没有在8天内占据并替换心脏组织，而是在心脏碎片周围生长并保持完整。如磺基罗丹明B试验所示，在1 microM的抗侵入浓度下，这三种化合物均未影响MCF-7 / 6细胞的生长。三种抗侵入性化合物均未刺激琼脂上的聚集体形成，因此对E-钙粘蛋白/连环蛋白复合物的作用难以实现。这是一种侵袭抑制剂，可以在MCF-7
• Kumar, Ajay; Malhotra, Sanjay; Vats, Archana, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2002, vol. 41, # 2, p. 360 - 367
  作者：Kumar, Ajay、Malhotra, Sanjay、Vats, Archana、Himanshu、Singh, Sanjay K.、Sharma, Sunil K.、Prasad, Ashok K.、Errington, William、Olsen, Carl E.、Jain, Subhash C.、Parmar, Virinder S.

  DOI：——

  日期：——
• Ram, Vishnu Ji; Nath, Mahendra; Singh, Sunil K., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996, vol. 35, # 3, p. 273 - 275
  作者：Ram, Vishnu Ji、Nath, Mahendra、Singh, Sunil K.

  DOI：——

  日期：——
• Ram Vishnu Ji, Haque Navedul, Kumar Singh Sanjay, Hussaini Falak Anwer, S+, Indian J. Chem. B, 32 (1993) N 9, S 924-928
  作者：Ram Vishnu Ji, Haque Navedul, Kumar Singh Sanjay, Hussaini Falak Anwer, S+

  DOI：——

  日期：——
• Synthesis of E - and Z -Pyrazolylacrylonitriles and their evaluation as novel antioxidants
  作者：Virinder S Parmar、Ajay Kumar、Ashok K Prasad、Sanjay K Singh、Naresh Kumar、Shubhasish Mukherjee、Hanumantharao G Raj、Sanjay Goel、William Errington、Mohindar S Puar

  DOI：10.1016/s0968-0896(99)00056-5

  日期：1999.7

  A facile synthesis of (Z)- and (E)-2-(5-arylpyrazol-3-yl)-3-(pyrrol-2-yl)acrylonitriles and (Z)-2-(1,3-diarylpyrazol-5-yl)-3-(pyrrol-2-yl)acrylonitriles, and isomerisation of (Z)-2-(5-arylpyrazolyl)acrylonitriles to (E)-2-(5-arylpyrazolyl)acrylonitriles under basic conditions have been reported. (Z)-2-(1,3-Diarylpyrazolyl)acrylonitrile did not undergo isomerisation under the similar conditions. New compounds were identified on the basis of their spectral data (H-1-, C-13-, H-1-H-1 COSY, NOESY, NOE, HMQC NMR, IR, UV and EI mass). The structures of one acrylonitrile and five of their precursor 6-arylpyran-2-ones and cyanomethylpyrazoles were confirmed by X-ray crystallographic studies. Effects of pyrazolylacrylonitriles and their precursors on rat liver-microsomal lipid peroxidation were evaluated in vitro with a view to establish structure-activity relationship and to identify a lead compound. (C) 1999 Elsevier Science Ltd. All rights reserved.