2-formylbicyclo[2.2.1]hept-2-ene | 25408-84-8

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机氧化物
• 英文名称: 2-formylbicyclo[2.2.1]hept-2-ene
• 英文别名: Bicyclo<2.2.1>hept-1-en-1-carbaldehyd；Bicyclo[2.2.1]hept-2-ene-2-carbaldehyde
• CAS: 25408-84-8
• 化学式: C₈H₁₀O
• mdl: MFCD24393549
• 分子量: 122.167
• InChiKey: WPOWLMALYNHBSG-UHFFFAOYSA-N

物化性质

• 沸点：
  203.4±9.0 °C(Predicted)
• 密度：
  1.185±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.625
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-formylbicyclo[2.2.1]hept-2-ene 在 氢气 作用下， 以 异丙醇 为溶剂， 149.84 ℃ 、1.0 MPa 条件下， 反应 0.75h， 生成 2-(hydroxymethyl)norborn-2-ene
  参考文献：
  名称：

  Ni-Fe基合金催化剂对不饱和羰基的选择性加氢

  摘要：

  通过简单的水热法和随后的H2处理制备的Ni-Fe合金催化剂在所研究的第二种金属（例如Al，Ga，In，Co和Ti）中，对于生物质衍生的糠醛加氢成糠醇表现出最大的活性和选择性。 。这项工作表明，Ni和Fe的合金化是实现不饱和羰基底物中C = O部分高度选择性氢化的关键因素。我们发现降低H2处理的温度（即降低微晶尺寸）；例如，与糠醛氢化相比，Ni-Fe（2）HT-573 K（TOF = 952 h-1）与Ni-Fe（2）HT-673（TOF = 375 h-1）相比，活性增加。该结果表明，低配位的Ni-Fe合金对于催化循环是必不可少的。此外，金属/载体界面的作用至关重要。尽管Ni-Fe / TiO 2，Ni-Fe / Al 2 O 3和Ni-Fe / CeO 2具有较高的催化性能，但负载在SiO 2，针铁矿和水滑石催化剂上的Ni-Fe无效。使用FT-IR测量的振动研究表明，糠醛通过η1（O）构

  DOI：

  10.1039/c7cy00945c
• 作为产物：
  描述：

  降樟脑 生成 2-formylbicyclo[2.2.1]hept-2-ene
  参考文献：
  名称：

  A Novel Synthesis of α,β-Unsaturated Aldehydes and Esters by Dye-Photooxygenation of Methyl Enol Ethers

  摘要：

  DOI：

  10.1055/s-1978-24681

文献信息

• Method for Producing Compound Containing BIS (Perfluoroalkylsulfonyl) Methyl Group and Salt Thereof, and Solid Electrolyte Membrane Produced Using Same
  申请人：CENTRAL GLASS COMPANY, LIMITED

  公开号：US20150266816A1

  公开（公告）日：2015-09-24

  [Problem] To provide a method for producing a compound having a bis(trifluoroalkanesulfonyl)methyl group, which is a compound having a high acidity degree and hydrophobicity and useful as a raw material compound for a resin, and a salt thereof in a simple manner. [Solution] A method for producing a compound containing a bis(perfluoroalkylsulfonyl)methyl group and represented by the following formula and a salt of the compound. (Rf represents a perfluoroalkyl group having 1 to 12 carbon atoms. A represents a monovalent organic group. Y represents a single bond or a C 1 -C 4 linear, C 3 -C 4 branched or C 3 -C 4 cyclic alkylene group wherein each of some or all of hydrogen atoms may be substituted with a fluorine atom, a chlorine atom, a bromine atom or an iodine atom and an ether bond or an ester bond may be contained.)

  提供一种简单的方法，用于生产具有高酸度和疏水性的双(三氟烷磺酰基)甲基基团的化合物，该化合物可作为树脂的原料化合物，并提供该化合物的盐。生产含有双(全氟烷基磺酰基)甲基基团的化合物及其盐的方法如下所示： （Rf代表具有1至12个碳原子的全氟烷基基团。A代表一价有机基团。Y代表单键或C1-C4线性、C3-C4支链或C3-C4环烷基基团，其中部分或全部氢原子可被氟原子、氯原子、溴原子或碘原子取代，并且可能包含醚键或酯键。）
• GENERATION OF ENDO- AND/OR EXO-NORBORNENECARBOXALDEHYDE AS AN INTERMEDIATE TO FUNCTIONALIZED NORBORNENES
  申请人：Bell Andrew

  公开号：US20090118539A1

  公开（公告）日：2009-05-07

  Embodiments in accordance with the present invention provide for forming essentially pure diastereomers of 5/6-substituted norbornene-type monomers. Further, embodiments in accordance with the present invention encompass polymerizing such diastereomers to form addition or ROMP polymers where a desired exo-/endo-ratio of the diastereomers is provided to the polymerization, such ratio designed to provide a desired ratio of endo-/exo-structured repeating units for a resulting polymer to have desired physical or chemical properties.

  根据本发明的实施例，提供形成基本纯的5/6-取代去氢莰烯型单体的异构体。此外，根据本发明的实施例涵盖聚合这种异构体以形成加成或ROMP聚合物，其中所提供给聚合反应的异构体的期望外/内比例设计为提供所得聚合物具有期望的物理或化学性质的外/内结构重复单元的期望比例。
• Novel compounds and their use as positive AMPA receptor modulators
  申请人：Neurosearch A/S.

  公开号：US20040043987A1

  公开（公告）日：2004-03-04

  The invention provides novel compounds represented by the general formula 5 compound represented by the formula: 1 wherein the bond represented by the broken line may be a single, a double bond or absent; and if the bond is absent, then the nitrogen is substituted with a hydrogen and R 2 ; X represents SO 2 or C═O or CH 2 ; Y represents —CH(R 4 )—, —N(R 4 )— or —N(R 4 )—CH 2 —, O; and the meaning of R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and R 8 are as defined in the application The compounds are useful as positive modulators of the AMPA-receptor.

  该发明提供了一种新型化合物，其通式5的化合物如下所示：其中由虚线表示的键可以是单键、双键或不存在；如果键不存在，则氮原子用氢和R2取代；X代表SO2或C═O或CH2；Y代表—CH(R4)—、—N(R4)—或—N(R4)—CH2—、O；R2、R3、R4、R5、R6、R7和R8的含义如申请中所定义。这些化合物可用作AMPA受体的阳性调节剂。
• Palladium-catalyzed hydrophenylation of bicyclic alkenes
  作者：Peter Mayo、William Tam

  DOI：10.1016/s0040-4020(02)01277-2

  日期：2002.11

  Palladium-catalyzed hydrophenylation reactions of bicyclic alkenes were investigated. These reactions were found to be completely chemo- and stereoselective, giving only exo products on the less substituted double bonds of bicyclic alkenes in moderate to good yields. For unsymmetrical bicyclic alkenes, regioselectivities of 52:48 to 100:0 were observed with various substituents on the bicyclic alkenes

  研究了钯催化双环烯烃的加氢苯基化反应。发现这些反应是完全化学和立体选择性的，仅以中等至良好的收率在双环烯烃的较少取代的双键上仅给出外显子产物。对于不对称的双环烯烃，在双环烯烃上具有各种取代基的区域选择性为52:48至100：0。
• POST-SYNTHETIC MODIFICATION OF NUCLEIC ACIDS BY INVERSE DIELS-ALDER REACTION
  申请人：WIESSLER Manfred

  公开号：US20130085271A1

  公开（公告）日：2013-04-04

  The present invention concerns a method and a kit for the post-synthetic modification of nucleic acids via an inverse Diels-Alder reaction.

  本发明涉及一种通过反向Diels-Alder反应对核酸进行后合成修饰的方法和试剂盒。