1-(4-fluorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid | 889939-73-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-fluorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid
• 英文别名: 1-[(4-fluorophenyl)methyl]triazole-4-carboxylic acid
• CAS: 889939-73-5
• 化学式: C₁₀H₈FN₃O₂
• mdl: MFCD08445754
• 分子量: 221.191
• InChiKey: RMWPNKWXZUADBT-UHFFFAOYSA-N

物化性质

• 沸点：
  458.0±55.0 °C(Predicted)
• 密度：
  1.43±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  68
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-(4-fluorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid 在 吡啶 、 草酰氯 、 N,N-二甲基甲酰胺 作用下， 以 二氯甲烷 为溶剂， 生成 1-(4-fluorobenzyl)-N-(4'-((1-methylpiperidin-4-yl)oxy)-[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazole-4-carboxamide
  参考文献：
  名称：

  Triazole containing novobiocin and biphenyl amides as Hsp90 C-terminal inhibitors

  摘要：

  设计、合成和评估了含有香豆素和联苯酰胺的1,2,3-三唑侧链，作为强效的Hsp90 C-末端抑制剂，对一系列癌细胞系表现出改进的抗增殖活性。

  DOI：

  10.1039/c4md00102h
• 作为产物：
  描述：

  对氟苯甲醇 在 sodium azide 、 copper(ll) sulfate pentahydrate 、 三溴化磷 、 sodium ascorbate 、 sodium hydroxide 作用下， 以 甲醇 、 二氯甲烷 、 水 、 二甲基亚砜 、 叔丁醇 为溶剂， 反应 20.0h， 生成 1-(4-fluorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid
  参考文献：
  名称：

  取代(1-(苄基)-1H-1,2,3-三唑-4-基)(哌嗪-1-基)甲酮偶联物的设计与合成：研究其凋亡诱导能力和微管蛋白聚合抑制

  摘要：

  设计、合成和筛选了取代的（1-（苄基）-1 H -1,2,3-三唑-4-基）（哌嗪-1-基）甲酮衍生物文库，并筛选了它们对 BT- 的体外细胞毒活性474、HeLa、MCF-7、NCI-H460 和 HaCaT 细胞，采用 3-(4,5-二甲基噻唑-2-基)-2,5-二苯基溴化四唑 (MTT) 测定。在所有合成的类似物中，化合物10ec对 BT-474 癌细胞系显示出最高的细胞毒性，IC 50值为 0.99 ± 0.01 μM。目标化合物 ( 10ec) 还对其微管蛋白聚合抑制研究进行了评估。详细的生物学研究如吖啶橙/溴化乙锭 (AO/EB)、DAPI 和膜联蛋白 V-FITC/碘化丙啶染色试验表明，化合物10ec诱导了 BT-474 细胞的凋亡。克隆形成试验显示 BT-474 细胞中的集落形成被10ec以浓度依赖性方式抑制。此外，流式细胞术分析显示，10ec通过在亚 G1 和 G2/M

  DOI：

  10.1039/d0md00162g

文献信息

• Highly regioselective and sustainable solar click reaction: a new post-synthetic modified triazole organic polymer as a recyclable photocatalyst for regioselective azide–alkyne cycloaddition reaction
  作者：Dolly Yadav、Nem Singh、Tae Wu Kim、Jae Young Kim、No-Joong Park、Jin-Ook Baeg

  DOI：10.1039/c9gc00894b

  日期：——

  and regioselectivity. The reaction was studied for a series of substrates and the absolute regioselectivity of a representative triazole product has also been confirmed by X-ray crystallography. The proficiency and chemical orthogonality of the Ni-TLOP are remarkable and it shows enhanced efficiency and regioselectivity. The use of a recyclable photocatalyst and non-hazardous reagents makes the catalytic

  在寻找独特而有效的催化剂以使该过程高效，绿色和可持续的过程中，对药用活性1,2,3-三唑的合成一直进行了严格的审查。在这里，我们提出了一种新的可见光活性镍（II）Cyclam集成的三唑连接的有机聚合物（Ni-TLOP）光催化剂，具有出色的效率和区域选择性，可合成1,2,3-三唑化合物。研究了一系列底物的反应，并且还通过X射线晶体学证实了代表性三唑产物的绝对区域选择性。Ni-TLOP的熟练度和化学正交性非常出色，并且显示出更高的效率和区域选择性。可循环使用的光催化剂和非危险试剂的使用使催化系统具有可持续性和环境友好性。这种光催化的点击反应技术已成功应用于最畅销的抗癫痫药rufinamide的合成。
• Synthesis and biological evaluation of 1-benzyl-N-(2-(phenylamino)pyridin-3-yl)-1H-1,2,3-triazole-4-carboxamides as antimitotic agents
  作者：Budaganaboyina Prasad、V. Lakshma Nayak、P.S. Srikanth、Mirza Feroz Baig、N.V. Subba Reddy、Korrapati Suresh Babu、Ahmed Kamal

  DOI：10.1016/j.bioorg.2018.11.002

  日期：2019.3

  A library of 1-benzyl-N-(2-(phenylamino)pyridin-3-yl)-1H-1,2,3-triazole-4-carboxamides (7a–al) have been designed, synthesized and screened for their anti-proliferative activity against some selected human cancer cell lines namely DU-145, A-549, MCF-7 and HeLa. Most of them have shown promising cytotoxicity against lung cancer cell line (A549), amongst them 7f was found to be the most potent anti-proliferative

  1-苄基-甲库ñ - （2-（苯基氨基）吡啶-3-基）-1- ħ 1,2,3-三唑-4-甲酰胺（图7a-人）已经被设计，合成和筛选其对某些选定的人类癌细胞系DU-145，A-549，MCF-7和HeLa具有抗增殖活性。它们中的大多数已显示出对肺癌细胞系（A549）的有希望的细胞毒性，其中7f被发现是最有效的抗增殖同源物。此外，7f表现出与 标准E7010（IC 50值为2.15）相当的微管蛋白聚合抑制作用（IC 50值为2.04 µM）。 µM）。此外，流式细胞仪分析表明该化合物通过在A549细胞中以G 2 / M期的细胞周期停滞来诱导凋亡。通过检查线粒体膜电位进一步观察到了细胞凋亡的诱导，并且通过Hoechst染色以及膜联蛋白V-FITC分析也证实了凋亡的诱导。此外，分子对接研究表明化合物7f与β-微管蛋白的秋水仙碱结合位点结合。因此，7f通过在秋水仙碱活性位点的结合抑制微管蛋白聚合并诱导细胞凋亡而表现出抗增殖特性。
• 4 β -amidotriazole linked podophyllotoxin congeners: DNA topoisomerase-IIα inhibition and potential anticancer agents for prostate cancer
  作者：V. Ganga Reddy、Srinivasa Reddy Bonam、T. Srinivasa Reddy、Ravikumar Akunuri、V.G.M. Naidu、V. Lakshma Nayak、Suresh K. Bhargava、H.M. Sampath Kumar、P. Srihari、Ahmed Kamal

  DOI：10.1016/j.ejmech.2017.12.050

  日期：2018.1

  and topo-II) have occupied a significant role in DNA replication, transcription, and are a promising set of antitumor targets. In the present approach, a series of new 4β-amidotriazole linked podophyllotoxin derivatives (10a-i and 11a-k) were designed, synthesized by employing the click chemistry and their biological activities were evaluated. The majority of derivatives showed promising antiproliferative

  拓扑异构酶（topo-I和topo-II）在DNA复制，转录中起着重要作用，并且是一组有希望的抗肿瘤靶标。在本方法中，一系列新的4个β -amidotriazole联鬼臼毒素衍生物（10A-I和图11A-K ）被设计，通过采用点击化学和它们的生物活性进行了评价合成。大多数衍生物在六种人类癌细胞系上显示出令人鼓舞的抗增殖活性，IC 50值范围为1至10μM。宫颈（HeLa），乳腺（MCF-7），前列腺（DU-145），肺（A549），肝（HepG2）和结肠（HT-29）。其中一些同类物10b，10g和10i已显示出显着的细胞毒性，对测试的癌细胞系的IC 50值<1μM，并且比依托泊苷具有更高的活性。拓扑异构酶介导的DNA弛豫试验结果表明，该衍生物能有效抑制拓扑异构酶II的活性。此外，对DU-145细胞的流式细胞仪分析表明，这些化合物可阻止细胞周期的G2 / M期。还对这些DU-145细胞进行
• Inhibition of noroviruses by piperazine derivatives
  作者：Dengfeng Dou、Guijia He、Sivakoteswara Rao Mandadapu、Sridhar Aravapalli、Yunjeong Kim、Kyeong-Ok Chang、William C. Groutas

  DOI：10.1016/j.bmcl.2011.10.122

  日期：2012.1

  There is currently an unmet need for the development of small-molecule therapeutics for norovirus infection. The piperazine scaffold, a privileged structure embodied in many pharmacological agents, was used to synthesize an array of structurally-diverse derivatives which were screened for anti-norovius activity in a cell-based replicon system. The studies described herein demonstrate for the first time that functionalized piperazine derivatives possess anti-norovirus activity. Furthermore, these studies have led to the identification of two promising compounds (6a and 9I) that can be used as a launching pad for the optimization of potency, cytotoxicity, and drug-like characteristics. (C) 2011 Elsevier Ltd. All rights reserved.
• Synthesis and biological evaluation of 1,2,3-triazole linked aminocombretastatin conjugates as mitochondrial mediated apoptosis inducers
  作者：Ahmed Kamal、Bajee Shaik、V. Lakshma Nayak、Burri Nagaraju、Jeevak Sopanrao Kapure、M. Shaheer Malik、Thokhir Basha Shaik、B. Prasad

  DOI：10.1016/j.bmc.2014.08.008

  日期：2014.10

  A series of 1,2,3-triazole linked aminocombretastatin conjugates were synthesized and evaluated for cytotoxicity, inhibition of tubulin polymerization and apoptosis inducing ability. Most of the conjugates exhibited significant anticancer activity against some representative human cancer cell lines and two of the conjugates 6d and 7c displayed potent cytotoxicity with IC50 values of 53 nM and 44 nM against A549 human lung cancer respectively, and were comparable to combretastatin A-4 (CA-4). SAR studies revealed that 1-benzyl substituted triazole moiety with an amide linkage at 3-position of B-ring of the combretastatin subunit are more active compared to 2-position. G2/M cell cycle arrest was induced by these conjugates 6d and 7c and the tubulin polymerization assay (IC50 of 1.16 μM and 0.95 μM for 6d and 7c, respectively) as well as immunofluorescence analysis showed that these conjugates effectively inhibit microtubule assembly at both molecular and cellular levels in A549 cells. Colchicine competitive binding assay suggested that these conjugates bind at the colchicine binding site of tubulin as also observed from the docking studies. Further, mitochondrial membrane potential, ROS generation, caspase-3 activation assay, Hoechst staining and DNA fragmentation analysis revealed that these conjugates induce cell death by apoptosis.